Staff Directory

Prof Colin Masters BMedSc(Hons), MBBS, MD, Hon.DLitt W.Aust., FRCPath, FRCPA, FFSc, FAA, FTSE, FAHMS

In 1984, Beyreuther and Masters purified and sequenced the amyloid constituent of the plaque in Alzheimer’s disease, and three years later, their group used this sequence to clone the gene encoding the Aβ amyloid peptide located on chromosome 21. These studies demonstrated that the Aβ amyloid was derived by proteolytic cleavage of a neuronal transmembrane receptor. Subsequent studies by many groups has shown that a variety of Aβ-amyloid oligomers lie at the centre of AD pathogenesis, and these are now the validated primary targets for both diagnostic and therapeutic strategies. Masters and Beyreuther therefore defined the principal molecular and genetic pathways leading to the current Aβ amyloid theory of causation of Alzheimer’s disease.
More recent studies from Masters and colleagues have also demonstrated the time-course over which the Aβ accumulates in the evolution of Alzheimer’s disease, using molecular PET- Aβ imaging, allowing the preclinical and prodromal stages to be identified during life. They have also identified some of the genetic determinants which affect the rates of cognitive decline. These insights into the natural history of Alzheimer’s disease will have a major impact on clinical trial design and provide prognostic information for subjects at risk.

Research Papers

Listed below are Prof Colin Masters's most recent publications.

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2017
2016
1977


Decreased body mass index in the preclinical stage of autosomal dominant Alzheimer's disease

Journal

Scientific Reports

Volume

7

Begin Page

Date

27/4/2017

Author(s)

Stephan Mueller, Oliver Preische, Hamid R Sohrabi, Susanne Graeber, Mathias Jucker, Janko Dietzsch, John M Ringman, Ralph N Martins, Eric McDade, Peter R Schofield, Bernardino Ghetti, Martin Rossor, Neill R Graff-Radford, Johannes Levin, Douglas Galasko, Kimberly A Quaid, Stephen Salloway, Chengjie Xiong, Tammie Benzinger, Virginia Buckles, Colin L Masters, Reisa Sperling, Randall J Bateman, John C Morris, Christoph Laske
Cognitive impairment and decline in cognitively normal older adults with high amyloid-β: A meta-analysis

Journal

Alzheimer's And Dementia: Diagnosis, Assessment And Disease Monitoring

Volume

6

Begin Page

108

Date

1/1/2017

Author(s)

JE Baker, YY Lim, RH Pietrzak, J Hassenstab, PJ Snyder, CL Masters, P Maruff
Characterization and Identification of Dityrosine Cross-Linked Peptides Using Tandem Mass Spectrometry

Journal

Analytical Chemistry

Volume

89

Begin Page

6137

Date

6/6/2017

Author(s)

Soumya Mukherjee, Eugene A Kapp, Amber Lothian, Anne M Roberts, Yury V Vasil'ev, Berin A Boughton, Kevin J Barnham, W Mei Kok, Craig A Hutton, Colin L Masters, Ashley I Bush, Joseph S Beckmann, Somdatta Ghosh Dey, Blaine R Roberts
Biochemically-defined pools of amyloid-beta in sporadic Alzheimer's disease: correlation with amyloid PET

Journal

Brain

Volume

140

Begin Page

1486

Date

1/5/2017

Author(s)

Blaine R Roberts, Monica Lind, Aaron Z Wagen, Alan Rembach, Tony Frugier, Qiao-Xin Li, Timothy M Ryan, Catriona A McLean, James D Doecke, Christopher C Rowe, Victor L Villemagne, Colin L Masters
Effect of APOE Genotype on Amyloid Deposition, Brain Volume, and Memory in Cognitively Normal Older Individuals

Journal

Journal Of Alzheimer's Disease

Volume

58

Begin Page

1293

Date

1/1/2017

Author(s)

YY Lim, R Williamson, SM Laws, VL Villemagne, P Bourgeat, C Fowler, S Rainey-Smith, O Salvado, RN Martins, CC Rowe, CL Masters, P Maruff, B Chambers, E Chiu, R Clarnette, D Darby, M Davison, J Drago, P Drysdale, J Gilbert, K Lim, N Lautenschlager, D LoGiudice, P McCardle, S McFarlane, A Mander, J Merory, D O'Connor, R Scholes, M Samuel, D Trivedi, M Woodward
APOE epsilon 4 Genotype, Amyloid, and Clinical Disease Progression in Cognitively Normal Older Adults

Journal

Journal Of Alzheimers Disease

Volume

57

Begin Page

411

Date

1/1/2017

Author(s)

Simone Hollands, Yen Ying Lim, Simon M Laws, Victor L Villemagne, Robert H Pietrzak, Karra Harrington, Tenielle Porter, Peter Snyder, David Ames, Christopher Fowler, Stephanie R Rainey-Smith, Ralph N Martins, Olivier Salvado, Joanne Robertson, Christopher C Rowe, Colin L Masters, Paul Maruff
A Multi-Cohort Study of ApoE epsilon 4 and Amyloid-beta Effects on the Hippocampus in Alzheimer's Disease

Journal

Journal Of Alzheimers Disease

Volume

56

Begin Page

1159

Date

1/1/2017

Author(s)

Wasim Khan, Vincent Giampietro, Tobias Banaschewski, Gareth J Barker, Arun LW Bokde, Christian Buechel, Patricia Conrod, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Anreas Heinz, Bernd Ittermann, HerveE Lemaitre, Frauke Nees, Tomas Paus, Zdenka Pausova, Marcella Rietschel, Michael N Smolka, Andreas Stroehle, Jeurgen Gallinat, Bruno Vellas, Hilkka Soininen, Iwona Kloszewska, Magda Tsolaki, Patrizia Mecocci, Christian Spenger, Victor L Villemagne, Colin L Masters, J-Sebastian Muehlboeck, Lars Backman, Laura Fratiglioni, Gregoria Kalpouzos, Lars-Olof Wahlund, Gunther Schumann, Simon Lovestone, Steven CR Williams, Eric Westman, Andrew Simmons
A classification algorithm for predicting progression from normal cognition to mild cognitive impairment across five cohorts: The preclinical AD consortium

Journal

Alzheimer's And Dementia: Diagnosis, Assessment And Disease Monitoring

Volume

8

Begin Page

147

Date

1/1/2017

Author(s)

AL Gross, JJ Hassenstab, SC Johnson, LR Clark, SM Resnick, M Kitner-Triolo, CL Masters, P Maruff, JC Morris, A Soldan, C Pettigrew, MS Albert
A beta-amyloid and Tau Imaging in Dementia

Journal

Seminars In Nuclear Medicine

Volume

47

Begin Page

75

Date

1/1/2017

Author(s)

Victor L Villemagne, Vincent Dore, Pierrick Bourgeat, Samantha C Burnham, Simon Laws, Olivier Salvado, Colin L Masters, Christopher C Rowe
18F-Florbetaben PET beta-amyloid binding expressed in Centiloids

Journal

European Journal Of Nuclear Medicine And Molecular Imaging

Volume

Not Found

Begin Page

1

Date

22/6/2017

Author(s)

CC Rowe, V Doré, G Jones, D Baxendale, RS Mulligan, S Bullich, AW Stephens, S de Santi, CL Masters, L Dinkelborg, VL Villemagne
Altered levels of blood proteins in Alzheimer's disease longitudinal study: Results from Australian Imaging Biomarkers Lifestyle Study of Ageing cohort

Journal

Alzheimer's And Dementia: Diagnosis, Assessment And Disease Monitoring

Volume

8

Begin Page

60

Date

1/1/2017

Author(s)

VB Gupta, E Hone, S Pedrini, J Doecke, S O'Bryant, I James, AI Bush, CC Rowe, VL Villemagne, D Ames, CL Masters, RN Martins
Using Robust Normative Data to Investigate the Neuropsychology of Cognitive Aging

Journal

Archives Of Clinical Neuropsychology

Volume

32

Begin Page

142

Date

1/3/2017

Author(s)

Karra D Harrington, Yen Ying Lim, David Ames, Jason Hassenstab, Stephanie Rainey-Smith, Joanne Robertson, Olivier Salvado, Colin L Masters, Paul Maruff
Plasma Cortisol, Brain Amyloid-β, and Cognitive Decline in Preclinical Alzheimer's Disease: A 6-Year Prospective Cohort Study

Journal

Biological Psychiatry: Cognitive Neuroscience And Neuroimaging

Volume

2

Begin Page

45

Date

1/1/2017

Author(s)

RH Pietrzak, SM Laws, YY Lim, SJ Bender, T Porter, J Doecke, D Ames, C Fowler, CL Masters, L Milicic, S Rainey-Smith, VL Villemagne, CC Rowe, RN Martins, P Maruff
Histopathology and Florbetaben PET in Patients Incorrectly Diagnosed with Alzheimer's Disease

Journal

Journal Of Alzheimers Disease

Volume

56

Begin Page

441

Date

1/1/2017

Author(s)

Marwan N Sabbagh, Barbara Schaeuble, Keshav Anand, Danielle Richards, Shigeo Murayama, Hiroyasu Akatsu, Masaki Takao, Christopher C Rowe, Colin L Masters, Henryk Barthel, Hermann-Josef Gertz, Oliver Peters, Natalie Rasgon, Aleksandar Jovalekic, Osama Sabri, Walter J Schulz-Schaeffer, John Seibyl

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