Staff Directory

Dr Daniel Scott

Laboratory Head, Receptor Structure and Drug Discovery Laboratory — Neuropeptides

I lead a group in the Neuropeptides division, focused on membrane protein engineering, structure and function. My work is focused on the development of new, generic protein engineering methods that can be applied to facilitate the application of structural biology and structure based drug design to traditionally challenging membrane protein targets such as G protein-coupled receptors (GPCRs). After completing my PhD on the relaxin and INSL3 receptors at The University of Melbourne in 2007, I worked as a postdoctoral researcher in the laboratory of Prof. Andreas Pl├╝ckthun in Zurich, Switzerland until the end of 2011. While in Zurich I invented a novel method, called CHESS, for the directed evolution of detergent-resistant membrane proteins. GPCRs stabilised with this method can be produced recombinantly in bacteria, purified and stored in detergents and experimentally probed as if they were highly stable soluble proteins. Such stabilised GPCRs can be applied to X-ray crystallography and NMR for structural studies, but can also be used to probe the molecular determinants of ligand binding, ligand-receptor selectivity and for drug discovery. I was recruited to The Florey in 2011 as a group leader, where my focus is on engineering and biophysical characterisation of GPCRs. In addition to my work on GPCRs, I enjoy developing new tools to help advance neuroscience (and other fields), such as denaturation resistant fluorescent proteins for cleared tissue imaging. I am a CI on four successful NHMRC project grants. I am also heavily involved in the commercialisation of research, being an inventor on 2 granted patents and a cofounder/shareholder of G7 Therapeutics AG. 

Research Papers

Listed below are Dr Daniel Scott's most recent publications.

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Biodiesel synthesis assisted by ultrasonication using engineered thermo-stable Proteus vulgaris lipase

Journal

Fuel

Volume

208

Begin Page

430

Date

15/11/2017

Author(s)

Shweta Gupta, Daniel Scott, Ratna Prabha, Muthupandian Ashokkumar
Distinct activation modes of the Relaxin Family Peptide Receptor 2 in response to insulin-like peptide 3 and relaxin

Journal

Scientific Reports

Volume

7

Begin Page

Date

12/6/2017

Author(s)

Shoni Bruell, Ashish Sethi, Nicholas Smith, Daniel J Scott, Mohammed Akhter Hossain, Qing-Ping Wu, Zhan-Yun Guo, Emma J Petrie, Paul R Gooley, Ross AD Bathgate
Characterisation of a cell-free synthesised G-protein coupled receptor

Journal

Scientific Reports

Volume

7

Begin Page

Date

24/4/2017

Author(s)

Patrick J Shilling, Fabian Bumbak, Daniel J Scott, Ross AD Bathgate, Paul R Gooley

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