Staff Directory

Dr Daniel Scott

Laboratory Head, Receptor Structure and Drug Discovery Laboratory — Neuropeptides

The Scott laboratory is focused on membrane protein engineering, structure and function. The foundation of the lab is the development of new, generic protein engineering methods that can be applied to facilitate the application of structural biology and structure based drug design to traditionally challenging membrane protein targets such as G protein-coupled receptors (GPCRs). Such stabilised proteins can be applied to X-ray crystallography and NMR for structural studies, but can also be used to probe the molecular determinants of ligand binding, ligand-receptor selectivity and for drug discovery. 

 

Daniel J. Scott career highlights

  • 2018 - NHMRC Project grant (Resolving and targeting the complex molecular mechanisms underlying GPCR signalling)
  • 2018 - NHMRC Project grant (Adenosine A1 receptor modulation: Structure, dynamics & novel pharmacological interventions)
  • 2017 - NHMRC Boosting Dementia Research Leadership Fellow (Targeting GPCRs in Alzheimer's Disease)
  • 2016 - NHMRC Project grant (Unravelling the binding and activation mechanism of complex G Protein-coupled receptor)
  • 2016 - Heptares Therapeutics acquires G7 Therapeutics
  • 2015 - NHMRC Project grant (Understanding mechanisms of allostery and biased agonism at the adenosine A1 receptor)
  • 2015 - NHMRC Project grant (Novel approaches to understanding peptide G-protein-coupled receptor activation)
  • 2015 - NHMRC Project grant (Stabilising G protein-coupled receptors for drug discovery)
  • 2014 - Crystal structures of CHESS-stabilized neurotensin receptor variants solved
  • 2013 - Australasian Society of Clinical and Experimental Pharmacology and Toxicology (ASCEPT) Denis Wade Johnson & Johnson New Investigator Award
  • 2013 - British Pharmacological Society (BPS)/ASCEPT Outstanding Young Investigator Prize
  • 2013 - Co-founded G7 Therapeutics AG, Switzerland
  • 2011 - Recruited to The Florey Institute of Neuroscience and Mental Health as a junior group leader
  • 2010 - Invented the Cellular High Throughput Encapsulation, Solubilization and Screening (CHESS) method
  • 2010 - University of Zurich Postdoctoral Fellowship, group of Andreas Pl├╝ckthun, Zurich, Switzerland
  • 2008 - NHMRC C.J. Martin Postoctoral Fellow, group of Andreas Pl├╝ckthun, Zurich, Switzerland (Directed evolution of stabilised G protein-coupled receptors)

Research Papers

Listed below are Dr Daniel Scott's most recent publications.

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N/A


A Novel Ultra-Stable, Monomeric Green Fluorescent Protein For Direct Volumetric Imaging of Whole Organs Using CLARITY.

Journal

Sci Rep

Volume

8

Begin Page

667

Date

12/1/N/A

Author(s)

Daniel J Scott, Natalie J Gunn, Kelvin J Yong, Verena C Wimmer, Nicholas A Veldhuis, Leesa M Challis, Mouna Haidar, Steven Petrou, Ross AD Bathgate, Michael DW Griffin
Biodiesel synthesis assisted by ultrasonication using engineered thermo-stable Proteus vulgaris lipase

Journal

Fuel

Volume

208

Begin Page

430

Date

15/11/N/A

Author(s)

Shweta Gupta, Daniel Scott, Ratna Prabha, Muthupandian Ashokkumar
Distinct activation modes of the Relaxin Family Peptide Receptor 2 in response to insulin-like peptide 3 and relaxin

Journal

Scientific Reports

Volume

7

Begin Page

Date

12/6/N/A

Author(s)

Shoni Bruell, Ashish Sethi, Nicholas Smith, Daniel J Scott, Mohammed Akhter Hossain, Qing-Ping Wu, Zhan-Yun Guo, Emma J Petrie, Paul R Gooley, Ross AD Bathgate
Characterisation of a cell-free synthesised G-protein coupled receptor

Journal

Scientific Reports

Volume

7

Begin Page

Date

24/4/N/A

Author(s)

Patrick J Shilling, Fabian Bumbak, Daniel J Scott, Ross AD Bathgate, Paul R Gooley
Label-free screening of single biomolecules through resistive pulse sensing technology for precision medicine applications

Journal

Nanotechnology

Volume

26

Begin Page

Date

8/5/N/A

Author(s)

S Harrer, SC Kim, C Schieber, S Kannam, N Gunn, S Moore, D Scott, R Bathgate, S Skafidas, JM Wagner
The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1

Journal

Nature Communications

Volume

7

Begin Page

Date

1/4/N/A

Author(s)

Ashish Sethi, Shoni Bruell, Nitin Patil, Mohammed Akhter Hossain, Daniel J Scott, Emma J Petrie, Ross AD Bathgate, Paul R Gooley
The relaxin peptide family and their novel G-protein coupled receptors

Journal

Letters In Peptide Science

Volume

10

Begin Page

393

Date

N/A

Author(s)

DJ SCOTT, TN WILKINSON, GW TREGEAR, R BATHGATE
Detection, localization, and action of the INSL3 receptor, LGR8, in rat kidney

Journal

Annals Of The New York Academy Of Sciences

Volume

1041

Begin Page

516

Date

N/A

Author(s)

P FU, P SHEN, C ZHAO, DJ SCOTT, C SAMUEL, JDC WADE, GW TREGEAR, R BATHGATE, AL GUNDLACH
Leucine-rich repeat-containing G-protein-coupled receptor 8 in mature glomeruli of developing and adult rat kidney and inhibition by insulin-like peptide-3 of glomerular cell proliferation.

Journal

Journal Of Endocrinology

Volume

189

Begin Page

397

Date

N/A

Author(s)

P Fu, PJ Shen, CX Zhao, DJ SCOTT, C SAMUEL, J WADE, G TREGEAR, R BATHGATE, A GUNDLACH
Modeling the Primary Hormone-Binding Site of RXFP1 and RXFP2

Journal

Annals Of The New York Academy Of Sciences

Volume

1160

Begin Page

74

Date

N/A

Author(s)

DJ SCOTT, G TREGEAR, R BATHGATE
Resolving the Unconventional Mechanisms Underlying RXFP1 and RXFP2 Receptor Function

Journal

Annals Of The New York Academy Of Sciences

Volume

1160

Begin Page

67

Date

N/A

Author(s)

BJ Hartley, DJ SCOTT, GE CALLANDER, TN Wilkinson, DE GANELLA, CKR KONG, S Layfield, T Ferraro, E PETRIE, R BATHGATE
Searching the human genome database for novel relaxin- and insulin-like peptides.

Journal

Letters In Peptide Science

Volume

8

Begin Page

129

Date

N/A

Author(s)

R BATHGATE, DJ SCOTT, SWL CHUNG, DW ELLYARD, AM GARREFFA, GW TREGEAR
Restricted expression of LGR8 in intralaminar thalamic nuclei of rat brain suggests a role in sensorimotor systems

Journal

Annals Of The New York Academy Of Sciences

Volume

1041

Begin Page

510

Date

N/A

Author(s)

P SHEN, P FU, KD PHELAN, DJ SCOTT, SL Layfield, GW TREGEAR, R BATHGATE, AL GUNDLACH
Characterization of the mouse and rat relaxin receptors

Journal

Annals Of The New York Academy Of Sciences

Volume

1041

Begin Page

8

Date

N/A

Author(s)

DJ SCOTT, SL Layfield, A RIESEWIJK, H MORITA, GW TREGEAR, R BATHGATE
Identification of the N-Linked Glycosylation Sites of the Human Relaxin Receptor and Effect of Glycosylation on Receptor Function

Journal

Biochemistry

Volume

47

Begin Page

6953

Date

N/A

Author(s)

Y YAN, DJ SCOTT, TN WILKINSON, Ji, G TREGEAR, R BATHGATE
Identification and characterization of the mouse and rat relaxin receptors as the novel orthologues of human leucine-rich repeat-containing G-protein-coupled receptor 7

Journal

Clinical And Experimental Pharmacology And Physiology

Volume

31

Begin Page

828

Date

N/A

Author(s)

DJ SCOTT, SL Layfield, A RIESEWIJK, H MORITA, GW TREGEAR, R BATHGATE
LGR7-truncate is a splice variant of the relaxin receptor LGR7 and is a relaxin antagonist in vitro

Journal

Annals Of The New York Academy Of Sciences

Volume

1041

Begin Page

22

Date

N/A

Author(s)

DJ SCOTT, GW TREGEAR, R BATHGATE
Defining the LGR8 Residues Involved in Binding Insulin-like Peptide 3

Journal

Molecular Endocrinology

Volume

21

Begin Page

1699

Date

N/A

Author(s)

DJ SCOTT, TN WILKINSON, SZ Zhang, TF Ferraro, J WADE, G TREGEAR, R BATHGATE
Characterization of the Rat INSL3 Receptor

Journal

Annals Of The New York Academy Of Sciences

Volume

1041

Begin Page

13

Date

N/A

Author(s)

DJ SCOTT, P FU, P SHEN, AL GUNDLACH, SL Layfield, A RIESEWIJK, H TOMIYAMA, JM HUTSON, GW TREGEAR, R BATHGATE
Solution structure and characterization of the receptor binding surface of insulin-like peptide 3*

Journal

Journal Of Biological Chemistry

Volume

281

Begin Page

28287

Date

N/A

Author(s)

K Rosengren, S Zhang, F Lin, N Daly, DJ Scott, R HUGHES, R Bathgate, D Craik, J Wade
Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules.

Journal

Journal Of Biological Chemistry

Volume

281

Begin Page

34942

Date

N/A

Author(s)

G TREGEAR, DJ SCOTT, S Layfield, Y YAN, S Sudo, AJW Hsueh, R BATHGATE
Characterization of the rat INSL3 receptor

Journal

Not Found

Volume

Not Found

Begin Page

34942

Date

N/A

Author(s)

D SCOTT, DJ Scott, P Fu, P Shen, A Gundlach, S Layfield, A Riesewijk, H Tomiyama, JM Hutson, GW Tregear, RAD Bathgate
The role of insulin 3, testosterone, mullerian inhibiting substance and relaxin in rat gubernacular growth.

Journal

Molecular Human Reproduction

Volume

8

Begin Page

900

Date

N/A

Author(s)

Y KUBOTA, C TEMELCOS, R BATHGATE, KJ SMITH, DJ SCOTT, CZ Zhao, JMH Hutson
Relaxin 3, a novel member of the insulin/relaxin superfamily of peptide hormones.

Journal

Biology Of Reproduction

Volume

66

Begin Page

249

Date

1/1/N/A

Author(s)

RA Bathgate, D Scott, CS Samuel, TCD Burazin, S Layfield, AA Claasz, NF Dawson, S Ma, C Bond, RJ Summers, JD Wade, GW Tregear
Modern perspectives on the structure, function and evolution of the relaxin-like peptides and their receptors

Journal

Current Medicinal Chemistry: Immunology, Endocrine And Metabolic Agents

Volume

5

Begin Page

369

Date

1/10/N/A

Author(s)

TN Wilkinson, D Scott, E Hopkins, RAD Bathgate

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