Staff Directory

Prof Colin Masters BMedSc(Hons), MBBS, MD, Hon.DLitt W.Aust., FRCPath, FRCPA, FFSc, FAA, FTSE, FAHMS

In 1984, Beyreuther and Masters purified and sequenced the amyloid constituent of the plaque in Alzheimer’s disease, and three years later, their group used this sequence to clone the gene encoding the Aβ amyloid peptide located on chromosome 21. These studies demonstrated that the Aβ amyloid was derived by proteolytic cleavage of a neuronal transmembrane receptor. Subsequent studies by many groups has shown that a variety of Aβ-amyloid oligomers lie at the centre of AD pathogenesis, and these are now the validated primary targets for both diagnostic and therapeutic strategies. Masters and Beyreuther therefore defined the principal molecular and genetic pathways leading to the current Aβ amyloid theory of causation of Alzheimer’s disease.
More recent studies from Masters and colleagues have also demonstrated the time-course over which the Aβ accumulates in the evolution of Alzheimer’s disease, using molecular PET- Aβ imaging, allowing the preclinical and prodromal stages to be identified during life. They have also identified some of the genetic determinants which affect the rates of cognitive decline. These insights into the natural history of Alzheimer’s disease will have a major impact on clinical trial design and provide prognostic information for subjects at risk.

Research Papers

Listed below are Prof Colin Masters's most recent publications.

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Evaluation of Cholinergic Deficiency in Preclinical Alzheimer's Disease Using Pupillometry

Journal

Journal Of Ophthalmology

Volume

Not Found

Begin Page

Date

1/1/2017

Author(s)

Shaun Frost, Liam Robinson, Christopher C Rowe, David Ames, Colin L Masters, Kevin Taddei, Stephanie R Rainey-Smith, Ralph N Martins, Yogesan Kanagasingam
Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults

Journal

Scientific Reports

Volume

7

Begin Page

Date

29/8/2017

Author(s)

Simon M Laws, Scott Gaskin, Amy Woodfield, Velandai Srikanth, David Bruce, Paul E Fraser, Tenielle Porter, Philip Newsholme, Nadeeja Wijesekara, Samantha Burnham, Vincent Dore, Qiao-Xin Li, Paul Maruff, Colin L Masters, Stephanie Rainey-Smith, Christopher C Rowe, Olivier Salvado, Victor L Villemagne, Ralph N Martins, Giuseppe Verdile
Presymptomatic atrophy in autosomal dominant Alzheimer's disease: A serial MRI study

Journal

Alzheimer's And Dementia

Volume

Not Found

Begin Page

Date

1/1/2017

Author(s)

KM Kinnunen, DM Cash, T Poole, C Frost, TLS Benzinger, RL Ahsan, KK Leung, MJ Cardoso, M Modat, IB Malone, JC Morris, RJ Bateman, DS Marcus, A Goate, SP Salloway, S Correia, RA Sperling, JP Chhatwal, RP Mayeux, AM Brickman, RN Martins, MR Farlow, B Ghetti, AJ Saykin, CR Jack, PR Schofield, E McDade, MW Weiner, JM Ringman, PM Thompson, CL Masters, CC Rowe, MN Rossor, S Ourselin, NC Fox
A rigorous method to enrich for exosomes from brain tissue.

Journal

J Extracell Vesicles

Volume

6

Begin Page

1348885

Date

2017

Author(s)

Laura J Vella, Benjamin J Scicluna, Lesley Cheng, Emma G Bawden, Colin L Masters, Ching-Seng Ang, Nicholas Willamson, Catriona McLean, Kevin J Barnham, Andrew F Hill
Trajectories of depressive and anxiety symptoms in older adults: a 6-year prospective cohort study.

Journal

Int J Geriatr Psychiatry

Volume

Not Found

Begin Page

1348885

Date

24/7/2017

Author(s)

Sophie E Holmes, Irina Esterlis, Carolyn M Mazure, Yen Ying Lim, David Ames, Stephanie Rainey-Smith, Chris Fowler, Kathryn Ellis, Ralph N Martins, Olivier Salvado, Vincent Doré, Victor L Villemagne, Christopher C Rowe, Simon M Laws, Colin L Masters, Robert H Pietrzak, Paul Maruff, Australian Imaging, Biomarkers and Lifestyle Research Group
The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease

Journal

Acta Neuropathologica Communications

Volume

5

Begin Page

Date

28/6/2017

Author(s)

David I Finkelstein, Jessica L Billings, Paul A Adlard, Scott Ayton, Amelia Sedjahtera, Colin L Masters, Simon Wilkins, David M Shackleford, Susan A Charman, Wojciech Bal, Izabela A Zawisza, Ewa Kurowska, Andrew L Gundlach, Sheri Ma, Ashley I Bush, Dominic J Hare, Philip A Doble, Simon Crawford, Elisabeth CL Gautier, Jack Parsons, Penny Huggins, Kevin J Barnham, Robert A Cherny
Reduced TRPC6 mRNA levels in the blood cells of patients with Alzheimer's disease and mild cognitive impairment.

Journal

Mol Psychiatry

Volume

Not Found

Begin Page

Date

11/7/2017

Author(s)

R Lu, J Wang, R Tao, J Wang, T Zhu, W Guo, Y Sun, H Li, Y Gao, W Zhang, CJ Fowler, Q Li, S Chen, Z Wu, CL Masters, C Zhong, N Jing, Y Wang, Y Wang

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