Staff Directory

Prof Colin Masters BMedSc(Hons), MBBS, MD, Hon.DLitt W.Aust., FRCPath, FRCPA, FFSc, FAA, FTSE, FAHMS

In 1984, Beyreuther and Masters purified and sequenced the amyloid constituent of the plaque in Alzheimer’s disease, and three years later, their group used this sequence to clone the gene encoding the Aβ amyloid peptide located on chromosome 21. These studies demonstrated that the Aβ amyloid was derived by proteolytic cleavage of a neuronal transmembrane receptor. Subsequent studies by many groups has shown that a variety of Aβ-amyloid oligomers lie at the centre of AD pathogenesis, and these are now the validated primary targets for both diagnostic and therapeutic strategies. Masters and Beyreuther therefore defined the principal molecular and genetic pathways leading to the current Aβ amyloid theory of causation of Alzheimer’s disease.
More recent studies from Masters and colleagues have also demonstrated the time-course over which the Aβ accumulates in the evolution of Alzheimer’s disease, using molecular PET- Aβ imaging, allowing the preclinical and prodromal stages to be identified during life. They have also identified some of the genetic determinants which affect the rates of cognitive decline. These insights into the natural history of Alzheimer’s disease will have a major impact on clinical trial design and provide prognostic information for subjects at risk.

Research Papers

Listed below are Prof Colin Masters's most recent publications.

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White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer’s disease

Journal

Plos One

Volume

13

Begin Page

Date

1/5/N/A

Author(s)

S Lee, ME Zimmerman, A Narkhede, SE Nasrabady, G Tosto, IB Meier, TLS Benzinger, DS Marcus, AM Fagan, NC Fox, NJ Cairns, DM Holtzman, V Buckles, B Ghetti, E McDade, RN Martins, AJ Saykin, CL Masters, JM Ringman, S Fӧrster, PR Schofield, RA Sperling, KA Johnson, JP Chhatwal, S Salloway, S Correia, CR Jack, M Weiner, RJ Bateman, JC Morris, R Mayeux, AM Brickman
Association of beta-Amyloid and Apolipoprotein E epsilon 4 With Memory Decline in Preclinical Alzheimer Disease

Journal

Jama Neurology

Volume

75

Begin Page

488

Date

1/4/N/A

Author(s)

Yen Ying Lim, Pawel Kalinowski, Robert H Pietrzak, Simon M Laws, Samantha C Burnham, David Ames, Victor L Villemagne, Christopher J Fowler, Stephanie R Rainey-Smith, Ralph N Martins, Christopher C Rowe, Colin L Masters, Paul T Maruff
Imaging tau and amyloid-beta proteinopathies in Alzheimer disease and other conditions

Journal

Nature Reviews Neurology

Volume

14

Begin Page

225

Date

1/4/N/A

Author(s)

Victor L Villemagne, Vincent Dore, Samantha C Burnham, Colin L Masters, Christopher C Rowe
Amyloid burden and incident depressive symptoms in preclinical Alzheimer's disease

Journal

Journal Of Affective Disorders

Volume

229

Begin Page

269

Date

15/3/N/A

Author(s)

Stephanie Perin, Karra D Harrington, Yen Ying Lim, Kathryn Ellis, David Ames, Robert H Pietrzak, Adrian Schembri, Stephanie Rainey-Smith, Olivier Salvado, Simon M Laws, Ralph N Martins, Victor L Villemagne, Christopher C Rowe, Colin L Masters, Paul Maruff
Alzheimer's Disease: A Journey (f)rom Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies-Gains from AIBL and DIAN Cohort Studies

Journal

Journal Of Alzheimers Disease

Volume

62

Begin Page

965

Date

1/1/N/A

Author(s)

Ralph N Martins, Victor Villemagnen, Hamid R Sohrabi, Pratishtha Chatterjee, Tejal M Shah, Giuseppe Verdile, Paul Fraser, Kevin Taddei, Veer B Gupta, Stephanie R Rainey-Smith, Eugene Hone, Steve Pedrini, Wei Ling Lim, Ian Martins, Shaun Frost, Sunil Gupta, Sid O'Bryant, Alan Rembach, David Ames, Kathryn Ellis, Stephanie J Fuller, Belinda Brown, Samantha L Gardener, Binosha Fernando, Prashant Bharadwaj, Samantha Burnham, Simon M Laws, Anna M Barron, Kathryn Goozee, Eka J Wahjoepramono, Prita R Asih, James D Doecke, Olivier Salvado, Ashley I Bush, Christopher C Rowe, Samuel E Gandy, Colin L Masters
CSF Tau supplements 14-3-3 protein detection for sporadic Creutzfeldt-Jakob disease diagnosis while transitioning to next generation diagnostics

Journal

Journal Of Clinical Neuroscience

Volume

50

Begin Page

292

Date

1/4/N/A

Author(s)

Qiao-Xin Li, Shiji Varghese, Shannon Sarros, Christiane Stehmann, James D Doecke, Christopher J Fowler, Colin L Masters, Steven J Collins
Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-Amyloid burden

Journal

Translational Psychiatry

Volume

8

Begin Page

292

Date

1/12/N/A

Author(s)

SR Rainey-Smith, GN Mazzucchelli, VL Villemagne, BM Brown, T Porter, M Weinborn, RS Bucks, L Milicic, HR Sohrabi, K Taddei, D Ames, P Maruff, CL Masters, CC Rowe, O Salvado, RN Martins, SM Laws
Erratum: Early behavioural changes in familial Alzheimers disease in the Dominantly Inherited Alzheimer Network (Brain (2015) 138 (103645) (10.1093/brain/awv004))

Journal

Brain

Volume

138

Begin Page

e401

Date

1/12/N/A

Author(s)

JM Ringman, LJ Liang, Y Zhou, S Vangala, E Teng, S Kremen, D Wharton, A Goate, DS Marcus, M Farlow, B Ghetti, E McDade, CL Masters, RP Mayeux, M Rossor, S Salloway, PR Schofield, JL Cummings, V Buckles, R Bateman, JC Morris
A NORMALISATION FRAMEWORK FOR QUANTITATIVE BRAIN IMAGING; APPLICATION TO QUANTITATIVE SUSCEPTIBILITY MAPPING

Journal

2017 Ieee 14th International Symposium On Biomedical Imaging (isbi 2017)

Volume

Not Found

Begin Page

97

Date

1/1/N/A

Author(s)

Amir Fazlollahi, Scott Ayton, Pierrick Bourgeat, Parnesh Raniga, Amanda Ng, Jurgen Fripp, David Ames, Colin L Masters, Christopher C Rowe, Victor L Villemagne, Ashley I Bush, Olivier Salvado
Plasma amyloid β 42/40 ratios as biomarkers for amyloid β cerebral deposition in cognitively normal individuals

Journal

Alzheimer's And Dementia: Diagnosis, Assessment And Disease Monitoring

Volume

8

Begin Page

179

Date

1/1/N/A

Author(s)

N Fandos, V Pérez-Grijalba, P Pesini, S Olmos, M Bossa, VL Villemagne, J Doecke, C Fowler, CL Masters, M Sarasa
A randomized, exploratory molecular imaging study targeting amyloid β with a novel 8-OH quinoline in Alzheimer's disease: The PBT2-204 IMAGINE study

Journal

Alzheimer's And Dementia: Translational Research And Clinical Interventions

Volume

3

Begin Page

622

Date

1/11/N/A

Author(s)

VL Villemagne, CC Rowe, KJ Barnham, R Cherny, M Woodward, S Bozinosvski, O Salvado, P Bourgeat, K Perez, C Fowler, A Rembach, P Maruff, C Ritchie, R Tanzi, CL Masters
Concordance Between Cerebrospinal Fluid Biomarkers with Alzheimer's Disease Pathology Between Three Independent Assay Platforms

Journal

Journal Of Alzheimers Disease

Volume

61

Begin Page

169

Date

1/1/N/A

Author(s)

James D Doecke, Alan Rembach, Victor L Villemagne, Shiji Varghese, Stephanie Rainey-Smith, Shannon Sarros, Lisbeth A Evered, Christopher J Fowler, Kelly K Pertile, Rebecca L Rumble, Brett Trounson, Kevin Taddei, Simon M Laws, S Lance Macaulay, Ashley I Bush, Kathryn A Ellis, Ralph Martins, David Ames, Brendan Silbert, Hugo Vanderstichele, Colin L Masters, David G Darby, Qiao-Xin Li, Steven Collins
KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE epsilon 4-positive cognitively normal adults with high A beta-amyloid burden

Journal

Scientific Reports

Volume

8

Begin Page

Date

1/2/N/A

Author(s)

Tenielle Porter, Samantha C Burnham, Vincent Dore, Greg Savage, Pierrick Bourgeat, Kimberly Begemann, Lidija Milicic, David Ames, Ashley I Bush, Paul Maruff, Colin L Masters, Christopher C Rowe, Stephanie Rainey-Smith, Ralph N Martins, David Groth, Giuseppe Verdile, Victor L Villemagne, Simon M Laws
High performance plasma amyloid-beta biomarkers for Alzheimer's disease

Journal

Nature

Volume

554

Begin Page

249

Date

8/2/N/A

Author(s)

Akinori Nakamura, Naoki Kaneko, Victor L Villemagne, Takashi Kato, James Doecke, Vincent Dore, Chris Fowler, Qiao-Xin Li, Ralph Martins, Christopher Rowe, Taisuke Tomita, Katsumi Matsuzaki, Kenji Ishii, Kazunari Ishii, Yutaka Arahata, Shinichi Iwamoto, Kengo Ito, Koichi Tanaka, Colin L Masters, Katsuhiko Yanagisawa
Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study

Journal

Lancet Neurology

Volume

17

Begin Page

241

Date

1/3/N/A

Author(s)

Brian A Gordon, Tyler M Blazey, Yi Su, Amrita Hari-Raj, Aylin Dincer, Shaney Flores, Jon Christensen, Eric McDade, Guoqiao Wang, Chengjie Xiong, Nigel J Cairns, Jason Hassenstab, Daniel S Marcus, Anne M Fagan, Clifford R Jack, Russ C Hornbeck, Katrina L Paumier, Beau M Ances, Sarah B Berman, Adam M Brickman, David M Cash, Jasmeer P Chhatwal, Stephen Correia, Stefan Forster, Nick C Fox, Neill R Graff-Radford, Christian la Fougere, Johannes Levin, Colin L Masters, Martin N Rossor, Stephen Salloway, Andrew J Saykin, Peter R Schofield, Paul M Thompson, Michael M Weiner, David M Holtzman, Marcus E Raichle, John C Morris, Randall J Bateman, Tammie LS Benzinger
Cerebral quantitative susceptibility mapping predicts amyloid-beta-related cognitive decline

Journal

Brain

Volume

140

Begin Page

2112

Date

1/8/N/A

Author(s)

Scott Ayton, Amir Fazlollahi, Pierrick Bourgeat, Parnesh Raniga, Amanda Ng, Yen Ying Lim, Ibrahima Diouf, Shawna Farquharson, Jurgen Fripp, David Ames, James Doecke, Patricia Desmond, Roger Ordidge, Colin L Masters, Christopher C Rowe, Paul Maruff, Victor L Villemagne, Olivier Salvado, Ashley I Bush
Modulation of Retinal Arteriolar Central Reflection by APOE Genotype

Journal

Current Alzheimer Research

Volume

14

Begin Page

916

Date

1/1/N/A

Author(s)

Shaun Frost, Alauddin Bhuiyan, David Offerman, James D Doecke, S Lance Macaulay, Hamid R Sohrabi, David Ames, Colin Masters, Ralph N Martins, Yogesan Kanagasingam
A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of beta-amyloid load in an AD cohort

Journal

Scientific Reports

Volume

7

Begin Page

Date

25/10/N/A

Author(s)

Steve Pedrini, Veer B Gupta, Eugene Hone, James Doecke, Sid O'Bryant, Ian James, Ashley I Bush, Christopher C Rowe, Victor L Villemagne, David Ames, Colin L Masters, Ralph N Martins
A systemic view of Alzheimer disease - insights from amyloid-beta metabolism beyond the brain

Journal

Nature Reviews Neurology

Volume

13

Begin Page

612

Date

1/10/N/A

Author(s)

Jun Wang, Ben J Gu, Colin L Masters, Yan-Jiang Wang
Evaluation of Cholinergic Deficiency in Preclinical Alzheimer's Disease Using Pupillometry

Journal

Journal Of Ophthalmology

Volume

Not Found

Begin Page

Date

1/1/N/A

Author(s)

Shaun Frost, Liam Robinson, Christopher C Rowe, David Ames, Colin L Masters, Kevin Taddei, Stephanie R Rainey-Smith, Ralph N Martins, Yogesan Kanagasingam
Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults

Journal

Scientific Reports

Volume

7

Begin Page

Date

29/8/N/A

Author(s)

Simon M Laws, Scott Gaskin, Amy Woodfield, Velandai Srikanth, David Bruce, Paul E Fraser, Tenielle Porter, Philip Newsholme, Nadeeja Wijesekara, Samantha Burnham, Vincent Dore, Qiao-Xin Li, Paul Maruff, Colin L Masters, Stephanie Rainey-Smith, Christopher C Rowe, Olivier Salvado, Victor L Villemagne, Ralph N Martins, Giuseppe Verdile
Presymptomatic atrophy in autosomal dominant Alzheimer's disease: A serial magnetic resonance imaging study

Journal

Alzheimers & Dementia

Volume

14

Begin Page

43

Date

1/1/N/A

Author(s)

Kirsi M Kinnunen, David M Cash, Teresa Poole, Chris Frost, Tammie LS Benzinger, R Laila Ahsan, Kelvin K Leung, M Jorge Cardoso, Marc Modat, Ian B Malone, John C Morris, Randall J Bateman, Daniel S Marcus, Alison Goate, Stephen P Salloway, Stephen Correia, Reisa A Sperling, Jasmeer P Chhatwal, Richard P Mayeux, Adam M Brickman, Ralph N Martins, Martin R Farlow, Bernardino Ghetti, Andrew J Saykin, Clifford R Jack, Peter R Schofield, Eric McDade, Michael W Weiner, John M Ringman, Paul M Thompson, Colin L Masters, Christopher C Rowe, Martin N Rossor, Sebastien Ourselin, Nick C Fox
A rigorous method to enrich for exosomes from brain tissue

Journal

Journal Of Extracellular Vesicles

Volume

6

Begin Page

Date

26/7/N/A

Author(s)

Laura J Vella, Benjamin J Scicluna, Lesley Cheng, Emma G Bawden, Colin L Masters, Ching-Seng Ang, Nicholas Willamson, Catriona McLean, Kevin J Barnham, Andrew F Hill
Trajectories of depressive and anxiety symptoms in older adults: a 6-year prospective cohort study

Journal

International Journal Of Geriatric Psychiatry

Volume

33

Begin Page

405

Date

1/2/N/A

Author(s)

Sophie E Holmes, Irina Esterlis, Carolyn M Mazure, Yen Ying Lim, David Ames, Stephanie Rainey-Smith, Chris Fowler, Kathryn Ellis, Ralph N Martins, Olivier Salvado, Vincent Dore, Victor L Villemagne, Christopher C Rowe, Simon M Laws, Colin L Masters, Robert H Pietrzak, Paul Maruff
The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease

Journal

Acta Neuropathologica Communications

Volume

5

Begin Page

Date

28/6/N/A

Author(s)

David I Finkelstein, Jessica L Billings, Paul A Adlard, Scott Ayton, Amelia Sedjahtera, Colin L Masters, Simon Wilkins, David M Shackleford, Susan A Charman, Wojciech Bal, Izabela A Zawisza, Ewa Kurowska, Andrew L Gundlach, Sheri Ma, Ashley I Bush, Dominic J Hare, Philip A Doble, Simon Crawford, Elisabeth CL Gautier, Jack Parsons, Penny Huggins, Kevin J Barnham, Robert A Cherny

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