Staff Directory

Prof Colin Masters BMedSc(Hons), MBBS, MD, Hon.DLitt W.Aust., FRCPath, FRCPA, FFSc, FAA, FTSE, FAHMS

In 1984, Beyreuther and Masters purified and sequenced the amyloid constituent of the plaque in Alzheimer’s disease, and three years later, their group used this sequence to clone the gene encoding the Aβ amyloid peptide located on chromosome 21. These studies demonstrated that the Aβ amyloid was derived by proteolytic cleavage of a neuronal transmembrane receptor. Subsequent studies by many groups has shown that a variety of Aβ-amyloid oligomers lie at the centre of AD pathogenesis, and these are now the validated primary targets for both diagnostic and therapeutic strategies. Masters and Beyreuther therefore defined the principal molecular and genetic pathways leading to the current Aβ amyloid theory of causation of Alzheimer’s disease.
More recent studies from Masters and colleagues have also demonstrated the time-course over which the Aβ accumulates in the evolution of Alzheimer’s disease, using molecular PET- Aβ imaging, allowing the preclinical and prodromal stages to be identified during life. They have also identified some of the genetic determinants which affect the rates of cognitive decline. These insights into the natural history of Alzheimer’s disease will have a major impact on clinical trial design and provide prognostic information for subjects at risk.

Research Papers

Listed below are Prof Colin Masters's most recent publications.

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A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort

Journal

Scientific Reports

Volume

7

Begin Page

Date

1/12/N/A

Author(s)

S Pedrini, VB Gupta, E Hone, J Doecke, S O'Bryant, I James, AI Bush, CC Rowe, VL Villemagne, D Ames, CL Masters, RN Martins, G Savage, B Wilson, P Bourgeat, J Fripp, S Gibson, H Leroux, S McBride, O Salvado, M Fenech, M Francois, M Barnes, J Baker, K Barnham, S Bellingham, J Bomke, SB Pejoska, R Buckley, L Cheng, S Collins, I Cooke, E Cyarto, D Darby, V Dore, D El-Sheikh, N Faux, C Fowler, K Harrington, A Hill, M Horne, G Jones, A Kamer, N Killeen, H Korrel, F Lamb, N Lautenschlager, K Lennon, QX Li, YY Lim, A Louey, L Macaulay, L Mackintosh, P Maruff, A McIlroy, J Nigro, K Perez, K Pertile, C Restrepo, BR Cardoso, A Rembach, B Roberts, J Robertson, R Rumble, T Ryan, J Sach, B Silbert, C Thai, B Trounson, I Volitakis, M Vovos, L Ward, A Watt, R Williams, M Woodward, P Yates, FY Ugarte, P Zhang, S Bird, B Brown, S Burnham, P Chatterjee, K Cox, S Fernandez, B Fernando, S Gardener, S Laws, F Lim, L Lim, M Tegg, K Lucas, G Martins
A systemic view of Alzheimer disease - insights from amyloid-beta metabolism beyond the brain

Journal

Nature Reviews Neurology

Volume

13

Begin Page

612

Date

1/10/N/A

Author(s)

Jun Wang, Ben J Gu, Colin L Masters, Yan-Jiang Wang
Evaluation of Cholinergic Deficiency in Preclinical Alzheimer's Disease Using Pupillometry

Journal

Journal Of Ophthalmology

Volume

Not Found

Begin Page

Date

1/1/N/A

Author(s)

Shaun Frost, Liam Robinson, Christopher C Rowe, David Ames, Colin L Masters, Kevin Taddei, Stephanie R Rainey-Smith, Ralph N Martins, Yogesan Kanagasingam
Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults

Journal

Scientific Reports

Volume

7

Begin Page

Date

29/8/N/A

Author(s)

Simon M Laws, Scott Gaskin, Amy Woodfield, Velandai Srikanth, David Bruce, Paul E Fraser, Tenielle Porter, Philip Newsholme, Nadeeja Wijesekara, Samantha Burnham, Vincent Dore, Qiao-Xin Li, Paul Maruff, Colin L Masters, Stephanie Rainey-Smith, Christopher C Rowe, Olivier Salvado, Victor L Villemagne, Ralph N Martins, Giuseppe Verdile
Presymptomatic atrophy in autosomal dominant Alzheimer's disease: A serial MRI study

Journal

Alzheimer's And Dementia

Volume

Not Found

Begin Page

Date

1/1/N/A

Author(s)

KM Kinnunen, DM Cash, T Poole, C Frost, TLS Benzinger, RL Ahsan, KK Leung, MJ Cardoso, M Modat, IB Malone, JC Morris, RJ Bateman, DS Marcus, A Goate, SP Salloway, S Correia, RA Sperling, JP Chhatwal, RP Mayeux, AM Brickman, RN Martins, MR Farlow, B Ghetti, AJ Saykin, CR Jack, PR Schofield, E McDade, MW Weiner, JM Ringman, PM Thompson, CL Masters, CC Rowe, MN Rossor, S Ourselin, NC Fox
A rigorous method to enrich for exosomes from brain tissue.

Journal

J Extracell Vesicles

Volume

6

Begin Page

1348885

Date

N/A

Author(s)

Laura J Vella, Benjamin J Scicluna, Lesley Cheng, Emma G Bawden, Colin L Masters, Ching-Seng Ang, Nicholas Willamson, Catriona McLean, Kevin J Barnham, Andrew F Hill
Trajectories of depressive and anxiety symptoms in older adults: a 6-year prospective cohort study.

Journal

Int J Geriatr Psychiatry

Volume

Not Found

Begin Page

1348885

Date

24/7/N/A

Author(s)

Sophie E Holmes, Irina Esterlis, Carolyn M Mazure, Yen Ying Lim, David Ames, Stephanie Rainey-Smith, Chris Fowler, Kathryn Ellis, Ralph N Martins, Olivier Salvado, Vincent Doré, Victor L Villemagne, Christopher C Rowe, Simon M Laws, Colin L Masters, Robert H Pietrzak, Paul Maruff, Australian Imaging, Biomarkers and Lifestyle Research Group
The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease

Journal

Acta Neuropathologica Communications

Volume

5

Begin Page

Date

28/6/N/A

Author(s)

David I Finkelstein, Jessica L Billings, Paul A Adlard, Scott Ayton, Amelia Sedjahtera, Colin L Masters, Simon Wilkins, David M Shackleford, Susan A Charman, Wojciech Bal, Izabela A Zawisza, Ewa Kurowska, Andrew L Gundlach, Sheri Ma, Ashley I Bush, Dominic J Hare, Philip A Doble, Simon Crawford, Elisabeth CL Gautier, Jack Parsons, Penny Huggins, Kevin J Barnham, Robert A Cherny
Reduced TRPC6 mRNA levels in the blood cells of patients with Alzheimer's disease and mild cognitive impairment.

Journal

Mol Psychiatry

Volume

Not Found

Begin Page

Date

11/7/N/A

Author(s)

R Lu, J Wang, R Tao, J Wang, T Zhu, W Guo, Y Sun, H Li, Y Gao, W Zhang, CJ Fowler, Q Li, S Chen, Z Wu, CL Masters, C Zhong, N Jing, Y Wang, Y Wang
Creutzfeldt-Jakob disease surveillance in Australia January 1970 to December 2003.

Journal

Communicable Diseases Intelligence

Volume

28

Begin Page

356

Date

1/1/N/A

Author(s)

GM Klug, V Lewis, A Boyd, JS Lee, CL Masters, SJ Collins
Reply from the authors

Journal

Neurology

Volume

70

Begin Page

1650

Date

1/4/N/A

Author(s)

CC Rowe, VL Villemagne, CL Masters
Erratum: Clearance mechanisms of Alzheimer's amyloid-Β peptide: Implications for therapeutic design and diagnostic tests (Molecular Psychiatry (2009) 14 (469-486) DOI: 10.1038/mp.2008.96)

Journal

Molecular Psychiatry

Volume

14

Begin Page

1144

Date

1/12/N/A

Author(s)

KA Bates, G Verdile, QX Li, D Ames, P Hudson, CL Masters, RN Martins
MENKES' KINKY (STEELY) HAIR DISEASE

Journal

Australasian Journal Of Dermatology

Volume

18

Begin Page

77

Date

1/1/N/A

Author(s)

A Hockey, CL Masters
Evidence for and against the transmissibility of alzheimer disease

Journal

Neurology

Volume

30

Begin Page

945

Date

1/1/N/A

Author(s)

J Goudsmit, CH Morrow, DM Asher, RT Yanagihara, CL Masters, CJ Gibbs, DC Gajdusek
Molecular biology in medicine: Alzheimer's disease, results and prospects

Journal

Laboratoriums Medizin

Volume

18

Begin Page

349

Date

1/1/N/A

Author(s)

K Beyreuther, CL Masters
Monoclonal antibodies to central nervous system antigens

Journal

Journal Of Neuroimmunology

Volume

1

Begin Page

391

Date

1/1/N/A

Author(s)

MC Franko, CL Masters, CJ Gibbs, D Carleton Gajdusek
Experimental Kuru in the gibbon and sooty mangabey and Creutzfeldt Jakob disease in the Pigtailed macaque

Journal

Journal Of Medical Primatology

Volume

5

Begin Page

205

Date

1/12/N/A

Author(s)

CL Masters, MP Alpers, DC Gajdusek, CJ Gibbs, BA Kakulas
Granulomatous angiitis and cerebral amyloid angiopathy presenting as a mass lesion

Journal

Neuropathology And Applied Neurobiology

Volume

17

Begin Page

149

Date

1/1/N/A

Author(s)

P LE COZ, J MIKOL, J FERRAND, F WOIMANT, C MASTERS, K BEYREUTHER, M HAGUENAU, J COPHIGNON, B PEPIN
Syndromes of amyotrophic lateral sclerosis and dementia: Relation to transmissible Creutzfeldt‐Jakob disease

Journal

Annals Of Neurology

Volume

14

Begin Page

17

Date

1/1/N/A

Author(s)

AM Salazar, CL Masters, DC Gajdusek, CJ Gibbs
Familial spongiform encephalopathies.

Journal

Research Publications - Association For Research In Nervous And Mental Disease

Volume

60

Begin Page

273

Date

1/1/N/A

Author(s)

DM Asher, CL Masters, DC Gajdusek, CJ Gibbs
Localization of the putative precursor of Alzheimer's disease-specific amyloid at nuclear envelopes of adult human muscle.

Journal

Embo Journal

Volume

7

Begin Page

367

Date

1/2/N/A

Author(s)

K Zimmermann, T Herget, JM Salbaum, W Schubert, C Hilbich, M Cramer, CL Masters, G Multhaup, J Kang, HG Lemaire
Neurodegeneration and dementia. Alzheimer's disease as a model.

Journal

Arzneimittel-forschung/drug Research

Volume

45

Begin Page

347

Date

1/3/N/A

Author(s)

K Beyreuther, CL Masters
Posterior fossa, aqueduct and fourth ventricle of the living mouse studied by positive contrast and plain radiography

Journal

Neuroradiology

Volume

11

Begin Page

93

Date

1/5/N/A

Author(s)

C Masters, LA Cala, TD Hughes
Oral transmission of kuru, Creutzfeldt-Jakob disease, and scrapie to nonhuman primates

Journal

Journal Of Infectious Diseases

Volume

142

Begin Page

205

Date

1/12/N/A

Author(s)

J Gibbs, HL Amyx, A Bacote, CL Masters, DC Gajdusek
Amyloid, aluminium and the aetiology of Alzheimer's disease [1]

Journal

Medical Journal Of Australia

Volume

164

Begin Page

252

Date

1/1/N/A

Author(s)

C Exley, E Storey, CL Masters

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