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9035 6507

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Kenneth Myer Building, 30 Royal Parade, Parkville, Australia

Staff Directory

Prof Andrew Gundlach PhD

Laboratory Head, Peptide Neurobiology Laboratory — Neuropeptides

Professor Andrew Gundlach is an NHMRC Senior Research Fellow and Principal Florey Research Fellow. He is Head of the Peptide Neurobiology Laboratory in the Neuropeptides Division of The Florey Institute of Neuroscience and Mental Health and is a member of the Florey Scientific Advisory Committee. Professor Gundlach has more than 30 years’ experience as a molecular and systems neuroscientist and his current research focuses on ascending arousal networks in the brain, and their neuromodulatory control of affective and cognitive processes under normal physiological conditions and in models of neurodegeneration, chronic pain, drug relapse, sleep dysfunction and psychiatric illnesses. His leading research on brain relaxin-3 peptide and receptor systems is currently supported by grants from NHMRC (Australia) and the Alzheimer’s Australia Dementia Research Foundation. He currently serves on the Editorial Boards of Frontiers in Neuroanatomy and Frontiers in Molecular Neuroscience, Neuropeptides, and Nature Scientific Reports. He is chairperson of the IUPHAR Nomenclature Committee for galanin peptides and receptors and a member of the IUPHAR Nomenclature Committee for relaxin peptides and receptors. Professor Gundlach is currently a council member of the International Society for Neurochemistry and the International Behavioural Neuroscience Society, and a program committee member for the International Congress on Neuroendocrinology 2018.

For further information on research interests and publications

please see research gate profile www.researchgate.net/profile/Andrew_Gundlach3

or Linked-In profile www.linkedin.com/in/andrew-gundlach-42135818

Selected Recent Publications

Albert-Gascó H, García-Avilés Á, Moustafa S, Gundlach AL, Olucha-Bordonau FE, Sánchez-Pérez AM. 2016. Central relaxin-3 receptor (RXFP3) activation increases ERK phosphorylation in septal cholinergic neurons. Brain Struct Funct doi: 10.1007/s00429-00016-01227-00428.

Kastman HE, Blasiak A, Siwiec M, Walker L, Krstew EV, Gundlach AL, Lawrence AJ. 2016. Nucleus incertus orexin2 receptors mediate alcohol-seeking in rats. Neuropharmacology 110: 82-91.

Ma S, Allocca G, Ong-Pålsson EKE, Hawkes D, McDougall SJ, Williams SJ, Bathgate RAD, Gundlach AL. 2016. Nucleus incertus promotes cortical desynchronization and behavioral arousal. Brain Struct Funct doi: 10.1007/s00429-00016-01230-00420.

Santos FN, Pereira CW, Sánchez-Pérez AM, Otero M, Ma S, Gundlach AL, Olucha-Bordonau FE. 2016. Comparative distribution of relaxin-3 inputs and calcium-binding protein-positive neurons in rat amygdala. Front Neuroanat 10: 36.

Walker LC, Kastman HE, Koeleman J, Smith CM, Perry CJ, Krstew EV, Gundlach AL, Lawrence AJ. 2016. Nucleus incertus corticotrophin-releasing factor 1 receptor signalling regulates alcohol-seeking in rats. Addiction Biol: doi:10.1111/adb.12426.

Blasiak A, Siwiec M, Grabowiecka A, Błasiak T, Czerw A, Blasiak E, Kania A, Rajfur Z, Lewandowski MH, Gundlach AL. 2015. Excitatory orexinergic innervation of rat nucleus incertus – Implications for ascending arousal, motivation and feeding control. Neuropharmacology 99: 432-447.

Hosken IT, Sutton SW, Smith CM, Gundlach AL. 2015. Relaxin-3 receptor (Rxfp3) gene knockout mice display reduced running wheel activity: Implications for role of relaxin-3/RXFP3 signalling in sustained arousal. Behav Brain Res 278: 167-175.

Lawther AJ, Clissold ML, Ma S, Kent S, Lowry CA, Gundlach AL, Hale MW. 2015. Anxiogenic drug administration and elevated plus maze exposure in rats activate populations of relaxin-3 neurons in the nucleus incertus and serotonergic neurons in the dorsal raphe nucleus. Neuroscience 303: 270-284.

Sánchez-Pérez AM, Arnal-Vicente I, Santos FN, Pereira CW, ElMlili N, Sanjuan J, Ma S, Gundlach AL, Olucha-Bordonau FE. 2015. Septal projections to the nucleus incertus in the rat: bidirectional pathways for modulation of hippocampal function. J Comp Neurol 523: 565-588.

Walker AW, Smith CM, Chua BE, Krstew EV, Zhang C, Gundlach AL, Lawrence AJ. 2015a. Relaxin-3 receptor (RXFP3) signalling mediates stress-related alcohol preference in mice. PLoS One 10: e0122504.

Walker AW, Smith CM, Gundlach AL, Lawrence AJ. 2015b. Relaxin-3 receptor (Rxfp3) gene deletion reduces operant sucrose- but not alcohol-responding in mice. Genes Brain Behav 14: 625–634.

Zhang C, Chua BE, Yang A, Shabanpoor F, Hossain MA, Wade JD, Rosengren KJ, Smith CM, Gundlach AL. 2015. Central relaxin-3 receptor (RXFP3) activation reduces elevated, but not basal, anxiety-like behaviour in C57BL/6J mice. Behav Brain Res 292: 125-132.

 

Research Papers

Listed below are Prof Andrew Gundlach's most recent publications.

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The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease

Journal

Acta Neuropathologica Communications

Volume

5

Begin Page

Date

28/6/N/A

Author(s)

David I Finkelstein, Jessica L Billings, Paul A Adlard, Scott Ayton, Amelia Sedjahtera, Colin L Masters, Simon Wilkins, David M Shackleford, Susan A Charman, Wojciech Bal, Izabela A Zawisza, Ewa Kurowska, Andrew L Gundlach, Sheri Ma, Ashley I Bush, Dominic J Hare, Philip A Doble, Simon Crawford, Elisabeth CL Gautier, Jack Parsons, Penny Huggins, Kevin J Barnham, Robert A Cherny
Dual-transmitter systems regulating arousal, attention, learning and memory

Journal

Neuroscience And Biobehavioral Reviews

Volume

Not Found

Begin Page

Date

1/1/N/A

Author(s)

S Ma, B Hangya, CS Leonard, W Wisden, AL Gundlach
Central amygdala relaxin-3/relaxin family peptide receptor 3 signalling modulates alcohol seeking in rats

Journal

British Journal Of Pharmacology

Volume

174

Begin Page

3359

Date

1/10/N/A

Author(s)

Leigh C Walker, Hanna E Kastman, Elena V Krstew, Andrew L Gundlach, Andrew J Lawrence
Relaxin-3/RXFP3 signalling in mouse hypothalamus: no effect of RXFP3 activation on corticosterone, despite reduced presynaptic excitatory input onto paraventricular CRH neurons in vitro

Journal

Psychopharmacology

Volume

234

Begin Page

1725

Date

1/6/N/A

Author(s)

C Zhang, DV Baimoukhametova, CM Smith, JS Bains, Andrew L Gundlach
Relaxin' the brain: a case for targeting the nucleus incertus network and relaxin-3/RXFP3 system in neuropsychiatric disorders

Journal

British Journal Of Pharmacology

Volume

174

Begin Page

1061

Date

1/5/N/A

Author(s)

Jigna Rajesh Kumar, Ramamoorthy Rajkumar, Tharindunee Jayakody, Subhi Marwari, Jia Mei Hong, Sherie Ma, Andrew L Gundlach, Mitchell KP Lai, Gavin S Dawe
Inhibition of oxytocin and vasopressin neuron activity in rat hypothalamic paraventricular nucleus by relaxin-3-RXFP3 signalling

Journal

Journal Of Physiology-london

Volume

595

Begin Page

3425

Date

1/6/N/A

Author(s)

Alan Kania, Anna Gugula, Agnieszka Grabowiecka, Camila de Avila, Tomasz Blasiak, Zenon Rajfur, Marian H Lewandowski, Grzegorz Hess, Elena Timofeeva, Andrew L Gundlach, Anna Blasiak
Relaxin-3 Inputs Target Hippocampal Interneurons and Deletion of Hilar Relaxin-3 Receptors in "Floxed-RXFP3" Mice Impairs Spatial Memory

Journal

Hippocampus

Volume

27

Begin Page

529

Date

1/5/N/A

Author(s)

M Haidar, G Guevremont, C Zhang, RAD Bathgate, E Timofeeva, CM Smith, AL Gundlach
Relaxin family peptide receptor 3- RXFP3 (GPCR135)

Journal

Not Found

Volume

Not Found

Begin Page

1

Date

1/12/N/A

Author(s)

A Gundlach, CM Smith
Distribution, physiology and pharmacology of relaxin-3/RXFP3 systems in brain

Journal

British Journal Of Pharmacology

Volume

174

Begin Page

1034

Date

1/5/N/A

Author(s)

Sherie Ma, Craig M Smith, Anna Blasiak, Andrew L Gundlach
MESOLIMBIC DOPAMINERGIC-NEURONS AND SOMATO-DENDRITIC MECHANISMS

Journal

Neuroscience Letters

Volume

15

Begin Page

165

Date

1/1/N/A

Author(s)

PM BEART, D MCDONALD, AL GUNDLACH
DOPAMINE METABOLISM, AS REFLECTED BY 3,4-DIHYDROXYPHENYLACETIC ACID (DOPAC) LEVELS IN THE MESOLIMBIC PATHWAY OF THE RAT

Journal

Clinical And Experimental Pharmacology And Physiology

Volume

6

Begin Page

699

Date

1/1/N/A

Author(s)

AL GUNDLACH, PM BEART
GLYCINE AND DOPAMINE IN THE VENTRAL TEGMENTAL AREA OF THE RAT

Journal

Clinical And Experimental Pharmacology And Physiology

Volume

7

Begin Page

688

Date

1/1/N/A

Author(s)

AL GUNDLACH, D MCDONALD, PM BEART
EFFECT OF MUSCIMOL ON DOPAMINE METABOLISM OF THE RAT HYPOTHALAMUS

Journal

Experientia

Volume

36

Begin Page

1312

Date

1/1/N/A

Author(s)

AL GUNDLACH, PM BEART
3,4-DIHYDROXYPHENYLACETIC ACID (DOPAC) AND THE RAT MESOLIMBIC DOPAMINERGIC PATHWAY - DRUG EFFECTS AND EVIDENCE FOR SOMATODENDRITIC MECHANISMS

Journal

British Journal Of Pharmacology

Volume

69

Begin Page

241

Date

1/1/N/A

Author(s)

PM BEART, AL GUNDLACH
EFFECT OF GABAERGIC DRUGS ON DOPAMINE CATABOLISM IN THE NIGROSTRIATAL AND MESOLIMBIC DOPAMINERGIC PATHWAYS OF THE RAT

Journal

Journal Of Pharmacy And Pharmacology

Volume

33

Begin Page

41

Date

1/1/N/A

Author(s)

AL GUNDLACH, PM BEART
DIFFERENTIAL-EFFECTS OF IV AND IP MUSCIMOL ON CENTRAL DOPAMINE METABOLISM

Journal

Psychopharmacology

Volume

74

Begin Page

71

Date

1/1/N/A

Author(s)

AL GUNDLACH, PM BEART
CHARACTERISTICS OF H-3-LABELED STRYCHNINE BINDING IN THE VENTRAL TEGMENTUM OF THE RAT

Journal

Clinical And Experimental Pharmacology And Physiology

Volume

8

Begin Page

645

Date

1/1/N/A

Author(s)

AL GUNDLACH, PM BEART
[STRYCHNINE-H-3 BINDING SUGGESTS GLYCINE RECEPTORS IN THE VENTRAL TEGMENTAL AREA OF RAT-BRAIN

Journal

Neuroscience Letters

Volume

22

Begin Page

289

Date

1/1/N/A

Author(s)

AL GUNDLACH, PM BEART
[SPIPERONE-H-3 BINDS TO 2 SITES IN HOMOGENATES OF THE RAT NUCLEUS ACCUMBENS

Journal

British Journal Of Pharmacology

Volume

74

Begin Page

P895

Date

1/1/N/A

Author(s)

PM BEART, AL GUNDLACH, D MCDONALD
[3H]-Spiperone binds to two sites in homogenates of the rat nucleus accumbens

Journal

British Journal Of Pharmacology

Volume

74

Begin Page

P895

Date

1/12/N/A

Author(s)

PM Beart, AL Gundlach, D McDonald
[3H]Strychnine binding suggests glycine receptors in the ventral tegmental area of rat brain

Journal

Neuroscience Letters

Volume

22

Begin Page

289

Date

25/3/N/A

Author(s)

AL Gundlach, PM Beart
THE LOW AFFINITY COMPONENT OF [H-3-LABELED SPIPERONE BINDING REFLECTS ASSOCIATION TO A NON-DOPAMINERGIC, NEUROLEPTIC SITE

Journal

Neuroscience Letters

Volume

29

Begin Page

147

Date

1/1/N/A

Author(s)

PM BEART, M KRSTICH, D MCDONALD, AL GUNDLACH
Properties of the low affinity sites labelled by (3H)spiperone on membranes from the rat nucleus accumbens

Journal

Neuroscience Letters

Volume

27

Begin Page

147

Date

1/1/N/A

Author(s)

PM Beart, M Krstich, D McDonald, AL Gundlach
NEUROCHEMICAL STUDIES OF THE MESOLIMBIC DOPAMINERGIC PATHWAY - GLYCINERGIC MECHANISMS AND GLYCINERGIC-DOPAMINERGIC INTERACTIONS IN THE RAT VENTRAL TEGMENTUM

Journal

Journal Of Neurochemistry

Volume

38

Begin Page

574

Date

1/1/N/A

Author(s)

AL GUNDLACH, PM BEART
LABELING OF HIGH (D-2 RECEPTOR) AND LOW AFFINITY SITES BY [H-3]-LABELED DOMPERIDONE IN HOMOGENATES OF THE CORPUS STRIATUM OF THE RAT

Journal

Neuroscience Letters

Volume

30

Begin Page

63

Date

1/1/N/A

Author(s)

HW RZEZNICZAK, AL GUNDLACH, PM BEART

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Qualifications

Listed below are Prof Andrew Gundlach's qualifications.
  • BSc (Hons)
  • Dip Ed
  • PhD

Awards

Listed below are Prof Andrew Gundlach's awards.
  • Recent Awards
  • NARSAD Independent Investigator Award 2013
  • Honorary Associate Professor, Anatomy and Neuroscience, The University of Melbourne 2000