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PHONE

9035 6507

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Kenneth Myer Building, 30 Royal Parade, Parkville, Australia

Staff Directory

Prof Andrew Gundlach PhD

Laboratory Head, Peptide Neurobiology Laboratory — Neuropeptides

Professor Andrew Gundlach is an NHMRC Senior Research Fellow and Principal Florey Research Fellow. He is Head of the Peptide Neurobiology Laboratory in the Neuropeptides Division of The Florey Institute of Neuroscience and Mental Health and is a member of the Florey Scientific Advisory Committee. Professor Gundlach has more than 30 years’ experience as a molecular and systems neuroscientist and his current research focuses on ascending arousal networks in the brain, and their neuromodulatory control of affective and cognitive processes under normal physiological conditions and in models of neurodegeneration, chronic pain, drug relapse, sleep dysfunction and psychiatric illnesses. His leading research on brain relaxin-3 peptide and receptor systems is currently supported by grants from NHMRC (Australia) and the Alzheimer’s Australia Dementia Research Foundation. He currently serves on the Editorial Boards of Frontiers in Neuroanatomy and Frontiers in Molecular Neuroscience, Neuropeptides, and Nature Scientific Reports. He is chairperson of the IUPHAR Nomenclature Committee for galanin peptides and receptors and a member of the IUPHAR Nomenclature Committee for relaxin peptides and receptors. Professor Gundlach is currently a council member of the International Society for Neurochemistry and the International Behavioural Neuroscience Society, and a program committee member for the International Congress on Neuroendocrinology 2018.

For further information on research interests and publications

please see research gate profile www.researchgate.net/profile/Andrew_Gundlach3

or Linked-In profile www.linkedin.com/in/andrew-gundlach-42135818

Selected Recent Publications

Albert-Gascó H, García-Avilés Á, Moustafa S, Gundlach AL, Olucha-Bordonau FE, Sánchez-Pérez AM. 2016. Central relaxin-3 receptor (RXFP3) activation increases ERK phosphorylation in septal cholinergic neurons. Brain Struct Funct doi: 10.1007/s00429-00016-01227-00428.

Kastman HE, Blasiak A, Siwiec M, Walker L, Krstew EV, Gundlach AL, Lawrence AJ. 2016. Nucleus incertus orexin2 receptors mediate alcohol-seeking in rats. Neuropharmacology 110: 82-91.

Ma S, Allocca G, Ong-Pålsson EKE, Hawkes D, McDougall SJ, Williams SJ, Bathgate RAD, Gundlach AL. 2016. Nucleus incertus promotes cortical desynchronization and behavioral arousal. Brain Struct Funct doi: 10.1007/s00429-00016-01230-00420.

Santos FN, Pereira CW, Sánchez-Pérez AM, Otero M, Ma S, Gundlach AL, Olucha-Bordonau FE. 2016. Comparative distribution of relaxin-3 inputs and calcium-binding protein-positive neurons in rat amygdala. Front Neuroanat 10: 36.

Walker LC, Kastman HE, Koeleman J, Smith CM, Perry CJ, Krstew EV, Gundlach AL, Lawrence AJ. 2016. Nucleus incertus corticotrophin-releasing factor 1 receptor signalling regulates alcohol-seeking in rats. Addiction Biol: doi:10.1111/adb.12426.

Blasiak A, Siwiec M, Grabowiecka A, Błasiak T, Czerw A, Blasiak E, Kania A, Rajfur Z, Lewandowski MH, Gundlach AL. 2015. Excitatory orexinergic innervation of rat nucleus incertus – Implications for ascending arousal, motivation and feeding control. Neuropharmacology 99: 432-447.

Hosken IT, Sutton SW, Smith CM, Gundlach AL. 2015. Relaxin-3 receptor (Rxfp3) gene knockout mice display reduced running wheel activity: Implications for role of relaxin-3/RXFP3 signalling in sustained arousal. Behav Brain Res 278: 167-175.

Lawther AJ, Clissold ML, Ma S, Kent S, Lowry CA, Gundlach AL, Hale MW. 2015. Anxiogenic drug administration and elevated plus maze exposure in rats activate populations of relaxin-3 neurons in the nucleus incertus and serotonergic neurons in the dorsal raphe nucleus. Neuroscience 303: 270-284.

Sánchez-Pérez AM, Arnal-Vicente I, Santos FN, Pereira CW, ElMlili N, Sanjuan J, Ma S, Gundlach AL, Olucha-Bordonau FE. 2015. Septal projections to the nucleus incertus in the rat: bidirectional pathways for modulation of hippocampal function. J Comp Neurol 523: 565-588.

Walker AW, Smith CM, Chua BE, Krstew EV, Zhang C, Gundlach AL, Lawrence AJ. 2015a. Relaxin-3 receptor (RXFP3) signalling mediates stress-related alcohol preference in mice. PLoS One 10: e0122504.

Walker AW, Smith CM, Gundlach AL, Lawrence AJ. 2015b. Relaxin-3 receptor (Rxfp3) gene deletion reduces operant sucrose- but not alcohol-responding in mice. Genes Brain Behav 14: 625–634.

Zhang C, Chua BE, Yang A, Shabanpoor F, Hossain MA, Wade JD, Rosengren KJ, Smith CM, Gundlach AL. 2015. Central relaxin-3 receptor (RXFP3) activation reduces elevated, but not basal, anxiety-like behaviour in C57BL/6J mice. Behav Brain Res 292: 125-132.

 

Research Papers

Listed below are Prof Andrew Gundlach's most recent publications.

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Modulation of forebrain function by nucleus incertus and relaxin-3/RXFP3 signaling

Journal

Cns Neuroscience And Therapeutics

Volume

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Begin Page

Date

1/1/N/A

Author(s)

FE Olucha-Bordonau, H Albert-Gascó, F Ros-Bernal, V Rytova, EKE Ong-Pålsson, S Ma, AM Sánchez-Pérez, AL Gundlach
Gram scale preparation of clozapine N-oxide (CNO), a synthetic small molecule actuator for muscarinic acetylcholine DREADDs

Journal

Methodsx

Volume

5

Begin Page

257

Date

1/1/N/A

Author(s)

PL van der Peet, C Gunawan, A Abdul-Ridha, S Ma, DJ Scott, AL Gundlach, RAD Bathgate, JM White, SJ Williams
GABAergic Neurons in the Rat Medial Septal Complex Express Relaxin-3 Receptor (RXFP3) mRNA

Journal

Frontiers In Neuroanatomy

Volume

11

Begin Page

Date

17/1/N/A

Author(s)

Hector Albert-Gasco, Sherie Ma, Francisco Ros-Bernal, Ana M Sanchez-Perez, Andrew L Gundlach, Francisco E Olucha-Bordonau
Safety and efficiency of ergotamine tartrate and dihydroergotamine in the treatment of migraine and status migrainosus

Journal

Neurology

Volume

45

Begin Page

577

Date

1/1/N/A

Author(s)

SD Silberstein, WB Young, WF Stewart, RB Lipton, DD Celentano, ML Reed, RB Lipton, WF Stewart, KR Merikangas, RB Lipton, WF Stewart, DD Celentano, ML Reed, DD Celentano, WF Stewart, MS Linet, MS Linet, WF Stewart, DD Celentano, D Ziegler, M Sprecher, SJ Peroutka, SJ Peroutka, N Adham, HT Kao, LE Schechter, V Hachinski, JW Norris, J Edmeads, P Cooper, AR Andersen, P Tfelt-Hansen, NA Lassen, MA Moskowitz
Nucleus incertus networks and their influence on arousal and cognition: dreadd studies

Journal

Journal Of Neurochemistry

Volume

134

Begin Page

233

Date

1/8/N/A

Author(s)

E Ong-Palsson, S Ma, D Hawkes, S McDougall, M White, R Barthgate, A Gundlach
RELAXIN-3/RXFP3 systems and central stress- and anxiety-related circuits in mice

Journal

Journal Of Neurochemistry

Volume

134

Begin Page

192

Date

1/8/N/A

Author(s)

C Zhang, A Yang, B Chua, G Guevremont, E Timofeeva, C Smith, A Gundlach
RELAXIN-3/RXFP3 signalling promotes motivational drive and stress resilience in mice

Journal

Journal Of Neurochemistry

Volume

134

Begin Page

192

Date

1/8/N/A

Author(s)

C Smith, I Hosken, A Walker, B Chua, C Zhang, D Denton, M McKinley, A Lawrence, E Timofeeva, A Gundlach
Elimination of RXFP3 signalling causes reduced circadian voluntary wheel running in mice: implications for Relaxin-3 networks in arousal and sleep control

Journal

Journal Of Sleep Research

Volume

21

Begin Page

120

Date

1/9/N/A

Author(s)

IT Hosken, C Smith, A Blasiak, AL Gundlach
RELAXIN-3/RXFP3 and the septohippocampal pathway: effects on learning and memory of viral-based RXFP3 changes in transgenic mice

Journal

Journal Of Neurochemistry

Volume

134

Begin Page

187

Date

1/8/N/A

Author(s)

M Haidar, D Hawkes, G Guevremont, S Ma, R Bathgate, E Timofeeva, C Smith, A Gundlach
OREXIN2 (OX2) receptors in nucleus incertus mediate stress-induced reinstatement of alcohol-seeking in alcohol-preferring (IP) rat

Journal

Journal Of Neurochemistry

Volume

134

Begin Page

214

Date

1/8/N/A

Author(s)

H Kastman, A Blasiak, M Siwiec, E Krstew, A Gundlach, A Lawrence
GAL3 galanin receptor

Journal

Not Found

Volume

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Begin Page

1

Date

1/12/N/A

Author(s)

A Gundlach
Galanin receptors

Journal

Not Found

Volume

Not Found

Begin Page

1

Date

1/12/N/A

Author(s)

A Gundlach
Relaxin-3

Journal

Not Found

Volume

Not Found

Begin Page

1

Date

1/12/N/A

Author(s)

AL Gundlach
Relaxin family peptide receptor 4- RXFP4 (GPCR142)

Journal

Not Found

Volume

Not Found

Begin Page

1

Date

1/12/N/A

Author(s)

A Gundlach
GAL1 galanin receptor

Journal

Not Found

Volume

Not Found

Begin Page

1

Date

1/12/N/A

Author(s)

A Gundlach
Gal2 galanin receptor

Journal

Not Found

Volume

Not Found

Begin Page

1

Date

1/12/N/A

Author(s)

A Gundlach
SIGMA-RECEPTORS ON NCB-20 HYBRID NEUROTUMOR CELLS LABELED WITH (+)(H-3)SKF 10,047 AND (+)(H-3)3-PPP

Journal

European Journal Of Pharmacology

Volume

124

Begin Page

183

Date

13/5/N/A

Author(s)

BL LARGENT, AL GUNDLACH, SH SNYDER
CORTICAL DIHYDROPYRIDINE BINDING-SITES ARE UNALTERED IN HUMAN ALCOHOLIC BRAIN

Journal

Annals Of Neurology

Volume

26

Begin Page

395

Date

1/9/N/A

Author(s)

JJ KRIL, AL GUNDLACH, PR DODD, GAR JOHNSTON, CG HARPER
Introduction

Journal

Journal Of The Autonomic Nervous System

Volume

72

Begin Page

73

Date

1/1/N/A

Author(s)

GA Head, AL Gundlach, IF Musgrave
PHENCYCLIDINE AND SIGMA-OPIATE RECEPTORS IN BRAIN - BIOCHEMICAL AND AUTORADIOGRAPHICAL DIFFERENTIATION

Journal

European Journal Of Pharmacology

Volume

113

Begin Page

465

Date

1/1/N/A

Author(s)

AL GUNDLACH, BL LARGENT, SH SNYDER
I-125-SPIPERONE - A NOVEL LIGAND FOR D2-DOPAMINE RECEPTORS

Journal

Life Sciences

Volume

35

Begin Page

1981

Date

1/1/N/A

Author(s)

AL GUNDLACH, BL LARGENT, SH SNYDER
PSYCHOTOMIMETIC OPIATE RECEPTORS LABELED AND VISUALIZED WITH (+)-[H-3]3-(3-HYDROXYPHENYL)-N-(1-PROPYL)PIPERIDINE

Journal

Proceedings Of The National Academy Of Sciences Of The United States Of America-biological Sciences

Volume

81

Begin Page

4983

Date

1/1/N/A

Author(s)

BL LARGENT, AL GUNDLACH, SH SNYDER
LOCALIZATION OF H-3 DIHYDROERGOTAMINE BINDING-SITES IN THE CAT CENTRAL-NERVOUS-SYSTEM - RELEVANCE TO MIGRAINE

Journal

Annals Of Neurology

Volume

29

Begin Page

91

Date

1/1/N/A

Author(s)

PJ GOADSBY, AL GUNDLACH
DISTRIBUTION OF GABA(A) RECEPTOR SUBUNIT MESSENGER-RNAS IN RAT LUMBAR SPINAL-CORD

Journal

Molecular Brain Research

Volume

10

Begin Page

179

Date

1/5/N/A

Author(s)

W WISDEN, AL GUNDLACH, EA BARNARD, PH SEEBURG, SP HUNT

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Qualifications

Listed below are Prof Andrew Gundlach's qualifications.
  • BSc (Hons)
  • Dip Ed
  • PhD

Awards

Listed below are Prof Andrew Gundlach's awards.
  • Recent Awards
  • NARSAD Independent Investigator Award 2013
  • Honorary Associate Professor, Anatomy and Neuroscience, The University of Melbourne 2000