Profile
PHONE

9035 6507

BUILDING

Kenneth Myer Building, 30 Royal Parade, Parkville, Australia

Staff Directory

Prof Andrew Gundlach PhD

Laboratory Head, Peptide Neurobiology Laboratory — Neuropeptides

Associate Professor Andrew Gundlach is an NHMRC Senior Research Fellow and Principal Florey Research Fellow. He is Head of the Peptide Neurobiology Laboratory in the Neuropeptides Division of The Florey Institute of Neuroscience and Mental Health and is a member of the Florey Scientific Advisory Committee. Dr Gundlach has more than 30 years’ experience as a molecular and systems neuroscientist and his current research focuses on ascending arousal networks in the brain, and their neuromodulatory control of affective and cognitive processes under normal physiological conditions and in models of neurodegeneration, chronic pain, drug relapse, sleep dysfunction and psychiatric illnesses. His leading research on brain relaxin-3 peptide and receptor systems is currently supported by grants from NHMRC (Australia) and the Alzheimer’s Australia Dementia Research Foundation. He currently serves on the Editorial Boards of Frontiers in Neuroanatomy and Frontiers in Molecular Neuroscience, Neuropeptides, and Nature Scientific Reports. He is chairperson of the IUPHAR Nomenclature Committee for galanin peptides and receptors and a member of the IUPHAR Nomenclature Committee for relaxin peptides and receptors. Dr Gundlach is currently a council member of the International Society for Neurochemistry and the International Behavioural Neuroscience Society, and a program committee member for the International Congress on Neuroendocrinology 2018.

For further information on research interests and publications

please see research gate profile www.researchgate.net/profile/Andrew_Gundlach3

or Linked-In profile www.linkedin.com/in/andrew-gundlach-42135818

Selected Recent Publications

Albert-Gascó H, García-Avilés Á, Moustafa S, Gundlach AL, Olucha-Bordonau FE, Sánchez-Pérez AM. 2016. Central relaxin-3 receptor (RXFP3) activation increases ERK phosphorylation in septal cholinergic neurons. Brain Struct Funct doi: 10.1007/s00429-00016-01227-00428.

Kastman HE, Blasiak A, Siwiec M, Walker L, Krstew EV, Gundlach AL, Lawrence AJ. 2016. Nucleus incertus orexin2 receptors mediate alcohol-seeking in rats. Neuropharmacology 110: 82-91.

Ma S, Allocca G, Ong-Pålsson EKE, Hawkes D, McDougall SJ, Williams SJ, Bathgate RAD, Gundlach AL. 2016. Nucleus incertus promotes cortical desynchronization and behavioral arousal. Brain Struct Funct doi: 10.1007/s00429-00016-01230-00420.

Santos FN, Pereira CW, Sánchez-Pérez AM, Otero M, Ma S, Gundlach AL, Olucha-Bordonau FE. 2016. Comparative distribution of relaxin-3 inputs and calcium-binding protein-positive neurons in rat amygdala. Front Neuroanat 10: 36.

Walker LC, Kastman HE, Koeleman J, Smith CM, Perry CJ, Krstew EV, Gundlach AL, Lawrence AJ. 2016. Nucleus incertus corticotrophin-releasing factor 1 receptor signalling regulates alcohol-seeking in rats. Addiction Biol: doi:10.1111/adb.12426.

Blasiak A, Siwiec M, Grabowiecka A, Błasiak T, Czerw A, Blasiak E, Kania A, Rajfur Z, Lewandowski MH, Gundlach AL. 2015. Excitatory orexinergic innervation of rat nucleus incertus – Implications for ascending arousal, motivation and feeding control. Neuropharmacology 99: 432-447.

Hosken IT, Sutton SW, Smith CM, Gundlach AL. 2015. Relaxin-3 receptor (Rxfp3) gene knockout mice display reduced running wheel activity: Implications for role of relaxin-3/RXFP3 signalling in sustained arousal. Behav Brain Res 278: 167-175.

Lawther AJ, Clissold ML, Ma S, Kent S, Lowry CA, Gundlach AL, Hale MW. 2015. Anxiogenic drug administration and elevated plus maze exposure in rats activate populations of relaxin-3 neurons in the nucleus incertus and serotonergic neurons in the dorsal raphe nucleus. Neuroscience 303: 270-284.

Sánchez-Pérez AM, Arnal-Vicente I, Santos FN, Pereira CW, ElMlili N, Sanjuan J, Ma S, Gundlach AL, Olucha-Bordonau FE. 2015. Septal projections to the nucleus incertus in the rat: bidirectional pathways for modulation of hippocampal function. J Comp Neurol 523: 565-588.

Walker AW, Smith CM, Chua BE, Krstew EV, Zhang C, Gundlach AL, Lawrence AJ. 2015a. Relaxin-3 receptor (RXFP3) signalling mediates stress-related alcohol preference in mice. PLoS One 10: e0122504.

Walker AW, Smith CM, Gundlach AL, Lawrence AJ. 2015b. Relaxin-3 receptor (Rxfp3) gene deletion reduces operant sucrose- but not alcohol-responding in mice. Genes Brain Behav 14: 625–634.

Zhang C, Chua BE, Yang A, Shabanpoor F, Hossain MA, Wade JD, Rosengren KJ, Smith CM, Gundlach AL. 2015. Central relaxin-3 receptor (RXFP3) activation reduces elevated, but not basal, anxiety-like behaviour in C57BL/6J mice. Behav Brain Res 292: 125-132.

 

Research Papers

Listed below are Prof Andrew Gundlach's most recent publications.

To improve loading times, 1/10 pages of publications are being displayed Click here to load all of this researcher's publications.


2017
2011
1982
1981
1980
1979


The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease

Journal

Acta Neuropathologica Communications

Volume

5

Begin Page

Date

28/6/2017

Author(s)

David I Finkelstein, Jessica L Billings, Paul A Adlard, Scott Ayton, Amelia Sedjahtera, Colin L Masters, Simon Wilkins, David M Shackleford, Susan A Charman, Wojciech Bal, Izabela A Zawisza, Ewa Kurowska, Andrew L Gundlach, Sheri Ma, Ashley I Bush, Dominic J Hare, Philip A Doble, Simon Crawford, Elisabeth CL Gautier, Jack Parsons, Penny Huggins, Kevin J Barnham, Robert A Cherny
Dual-transmitter systems regulating arousal, attention, learning and memory

Journal

Neuroscience And Biobehavioral Reviews

Volume

Not Found

Begin Page

Date

1/1/2017

Author(s)

S Ma, B Hangya, CS Leonard, W Wisden, AL Gundlach
Central amygdala relaxin-3/relaxin family peptide receptor 3 signalling modulates alcohol seeking in rats.

Journal

Br J Pharmacol

Volume

174

Begin Page

3359

Date

10/2017

Author(s)

Leigh C Walker, Hanna E Kastman, Elena V Krstew, Andrew L Gundlach, Andrew J Lawrence
Relaxin-3/RXFP3 signalling in mouse hypothalamus: no effect of RXFP3 activation on corticosterone, despite reduced presynaptic excitatory input onto paraventricular CRH neurons in vitro

Journal

Psychopharmacology

Volume

234

Begin Page

1725

Date

1/6/2017

Author(s)

C Zhang, DV Baimoukhametova, CM Smith, JS Bains, Andrew L Gundlach
Relaxin' the brain: a case for targeting the nucleus incertus network and relaxin-3/RXFP3 system in neuropsychiatric disorders

Journal

British Journal Of Pharmacology

Volume

174

Begin Page

1061

Date

1/5/2017

Author(s)

Jigna Rajesh Kumar, Ramamoorthy Rajkumar, Tharindunee Jayakody, Subhi Marwari, Jia Mei Hong, Sherie Ma, Andrew L Gundlach, Mitchell KP Lai, Gavin S Dawe
Inhibition of oxytocin and vasopressin neuron activity in rat hypothalamic paraventricular nucleus by relaxin-3-RXFP3 signalling

Journal

Journal Of Physiology-london

Volume

595

Begin Page

3425

Date

1/6/2017

Author(s)

Alan Kania, Anna Gugula, Agnieszka Grabowiecka, Camila de Avila, Tomasz Blasiak, Zenon Rajfur, Marian H Lewandowski, Grzegorz Hess, Elena Timofeeva, Andrew L Gundlach, Anna Blasiak
Relaxin-3 Inputs Target Hippocampal Interneurons and Deletion of Hilar Relaxin-3 Receptors in "Floxed-RXFP3" Mice Impairs Spatial Memory

Journal

Hippocampus

Volume

27

Begin Page

529

Date

1/5/2017

Author(s)

M Haidar, G Guevremont, C Zhang, RAD Bathgate, E Timofeeva, CM Smith, AL Gundlach
Distribution, physiology and pharmacology of relaxin-3/RXFP3 systems in brain

Journal

British Journal Of Pharmacology

Volume

174

Begin Page

1034

Date

1/5/2017

Author(s)

Sherie Ma, Craig M Smith, Anna Blasiak, Andrew L Gundlach

To improve loading times, 1/10 pages of publications are being displayed Click here to load all of this researcher's publications.

Qualifications

Listed below are Prof Andrew Gundlach's qualifications.
  • BSc (Hons)
  • Dip Ed
  • PhD

Awards

Listed below are Prof Andrew Gundlach's awards.
  • Recent Awards
  • NARSAD Independent Investigator Award 2013
  • Honorary Associate Professor, Anatomy and Neuroscience, The University of Melbourne 2000