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Dr Sarah Gordon

Lab Head - Presynaptic Physiology — Neurodegeneration

Dr Sarah Gordon was awarded her PhD from the University of Newcastle in 2009. She undertook postdoctoral studies at the University of Edinburgh in the lab of Prof Mike Cousin, where she defined the function of the integral synaptic vesicle (SV) protein synaptophysin. She went on to determine the pathological roles of synaptophysin, and another key SV protein, synaptotagmin, in intellectual disability. For this work she was awarded the prestigious JBC Herb Tabor Young Investigator Award. Dr Gordon returned to Australia in 2015 to join the Neurodegeneration group at the Florey Institute of Neuroscience and Mental Health, where her work focusses on determining how dysfunction in presynaptic proteins (including alpha synuclein) contributes to the pathogenesis of neurodegenerative and neurodevelopmental conditions.


Recent Publications:

  • Gordon, S.L. & Cousin, M.A. (2016) The iTRAPs: guardians of synaptic vesicle cargo retrieval during endocytosis, Frontiers in Synaptic Neuroscience, 8.
  • Gordon, S.L., Harper, C.B., Smillie, K.J., Cousin, M.A. (2016) A Fine Balance of Synaptophysin Levels Underlies Efficient Retrieval of Synaptobrevin II to Synaptic Vesicles, PLoS One, 11 (2).
  • Baker, K., Gordon, S.L., Grozeva, D., van Kogelenberg, M., Roberts, N.Y., Pike, M., Blair, E., Hurles, M.E., Chong, W.K., Baldeweg, T., Kurian, M.A., Boyd, S. UK10K consortium, Cousin, M.A., Raymond, L. (2015) A human mutation in SYT1 perturbs synaptic vesicle cycling, Journal of Clinical Investigation, 125 (4): 1670-8.
  • Zhang, N.*, Gordon, S.L.*, Fritsch, M.J.*, Esoof, N.*, Campbell, D.G., Gourlay, R., Velupillai, S., Macartney, T, Peggie, M., van Aalten, D.M.F., Cousin, M.A., Alessi, D.R. (2015) Phosphorylation of Synaptic Vesicle Protein 2A at Thr84 by Casein Kinase 1 Family Kinases Controls the Specific Retrieval of Synaptotagmin-1, Journal of Neuroscience, 35 (6): 2492-2507. * these authors contributed equally to this work
  • Gordon, S.L. & Cousin, M.A. (2014) The Sybtraps: Control of Synaptobrevin Traffic by Synaptophysin, α-Synuclein and AP-180, Traffic, 15 (3), 245-54.
  • Kavanagh, D.M., Smyth, A.M., Martin, K.J., Dun, A., Brown, E.R., Gordon, S., Smillie, K.J., Chamberlain, L.H., Wilson, R.S., Yang, L., Lu, W., Cousin, M.A., Rickman, C., Duncan, R.R. (2014) A molecular toggle after exocytosis sequesters the presynaptic syntaxin1a molecules involved in prior vesicle fusion, Nature Communications, 5:5774.
  • Carpanini, S.M., McKie, L., Thomson, D., Wright, A.K., Gordon, S.L., Roche, S.L., Handley, M.T., Morrison, H., Brownstein, D., Wishart, T.M., Cousin, M.A., Gillingwater, T.H., Aligianis, I.A., Jackson, I.J. (2014) A novel mouse model of Warburg Micro Syndrome reveals roles for RAB18 in eye development and organisation of the neuronal cytoskeleton, Disease Models and Mechanisms, 7 (6), 11-22.
  • Gordon, S.L. & Cousin, M.A. (2013) X-linked intellectual disability-associated mutations in synaptophysin disrupt synaptobrevin II retrieval, Journal of Neuroscience, 33 (34), 13695-700.
  • Gordon, S.L., Leube, R.E., Cousin, M.A. (2011) Synaptophysin is required for synaptobrevin retrieval during synaptic vesicle endocytosis, Journal of Neuroscience, 31 (39), 14032-36.

Research Papers

Listed below are Dr Sarah Gordon's most recent publications.




Qualifications

Listed below are Dr Sarah Gordon's qualifications.
  • PhD (Medical Biochemistry)
  • Bachelor of Biomedical Science (Hons)

Awards

Listed below are Dr Sarah Gordon's awards.
  • Journal of Biological Chemistry Herb Tabor Young Investigator Award (2014)
  • Beryl Nashar Young Researcher Award, University of Newcastle Alumni Awards (finalist, 2014)
  • Kellerman Award: University of Newcastle award for outstanding achievement in Medical Biochemistry (2009)