Staff Directory

Prof David Finkelstein

Since graduating with a PhD in Physiology (1991), I have worked to translate knowledge from fundamental science projects to provide clinical applications. Initially my research interests were centered on the physiology of control of movement, age related neurodegeneration and regeneration. I have subsequently used this basic science knowledge and applied it into developing novel therapeutic avenues for the treatment of Parkinson’s disease and parkinsonism. I have authored more than 110 refereed journal reports, plus reviews and book chapters. Of my 110 journal articles, I have been cited over 3,000 times since 2000 (Scopus), with 27 publications with more than 50 citations. Since 2009 I have published 54 publications, and on 21 of these I was first, last or corresponding author.

I am a current board member (2014-) of Parkinson’s Victoria, an organization that raises awareness and funds for services and research that improves the quality of life for people living with Parkinson’s in Victoria, Australia (http://www.parkinsonsvic.org.au/ ). I am a Chair of the World Parkinson’s Day committee (2013-).

Based on my knowledge and expertise, I was invited to be scientific consultant for two local biotech companies, Prana Biotechnology Ltd (2006-ongoing) and Procypria Biotechnology Ltd (2009-2012), as well as international companies, Commonwealth Serum laboratories (2009-2012) and the Collaborative Medicinal Development LLC, USA (2013-present). The aim of consulting with these companies is to work in partnership to develop new compounds that could potentially slow the progression of neurodegenerative diseases. My skills lie in the pre-clinical testing of new compounds in animal models of disease. As head of the preclinical Parkinson's disease development team at Prana Biotechnology, I have been an integral component in progressing specific lead compounds to preclinical toxicology screening (PBT434). The translational work that I commenced is currently progressing along the drug regulatory pathways. My collaboration with these biotechnology companies has increased the likelihood of a clinically relevant compound being available for the treatment of Parkinson’s disease.

I have been involved in the supervision and mentoring of 12 graduate students, 2 of which have won Faculty of Medicine, Dentistry and Health Sciences prizes. 4 have been awarded NHMRC Early Career Fellowships.

I am an academic editor for PLOS One (since 2009) and Journal of Alzheimer’s Disease (2015). I am an ad hoc reviewer of ~50 articles per year. I gave reviewed grants for the NHMRC, Medical Research Council (New Zealand) Alzheimer’s Association and Parkinson’s UK. I have acted as an external reviewer for The Eskitis Institute for Drug Discovery at Griffith University, Queensland Australia.. Complete List of Published Work in My Bibliography.

Research Papers

Listed below are Prof David Finkelstein's most recent publications.

To improve loading times, 1/8 pages of publications are being displayed Click here to load all of this researcher's publications.


N/A


Neuronal nicotinic receptors: insights gained from gene knockout and knockin mutant mice

Journal

Cellular And Molecular Life Sciences

Volume

60

Begin Page

1267

Date

1/7/N/A

Author(s)

J Drago, CD McColl, MK Horne, DI Finkelstein, SA Ross
Serotonin dysfunction in Parkinson's disease does not correlate with levodopa-induced dyskinesias

Journal

Movement Disorders

Volume

28

Begin Page

S366

Date

1/6/N/A

Author(s)

P Cheshire, S Ayton, K Bertram, H Ling, SS O'Sullivan, A Li, G Halliday, C McLean, T Revesz, DI Finkelstein, E Storey, DR Williams
The neuroinflammatory response induced by MPTP is altered in mice lacking the type-I interferon-alpha receptor-1 (IFNAR1)

Journal

Movement Disorders

Volume

28

Begin Page

S367

Date

1/6/N/A

Author(s)

JM Taylor, BS Main, M Zhang, S Ayton, D Finkelstein, PJ Crack
Nfix is a novel regulator of murine hematopoietic stem and progenitor cell survival

Journal

Blood

Volume

122

Begin Page

2987

Date

24/10/N/A

Author(s)

Per Holmfeldt, Jennifer Pardieck, Anjelica C Saulsberry, Satish Kumar Nandakumar, David Finkelstein, John T Gray, Derek A Persons, Shannon McKinney-Freeman
Behavioural effects of neurosurgery to the substantia nigra pars reticulata in parkinsonian monkeys

Journal

Movement Disorders

Volume

17

Begin Page

S185

Date

1/1/N/A

Author(s)

JM Henderson, DI Finkelstein, D Stanic, D Tomas, J Patch, D Bourke
Proconvulsant-ionduced seizures in alpha-4 nicotinic acetylocholine receptor subunit knockout mice

Journal

Neuropharmacology

Volume

43

Begin Page

55

Date

N/A

Author(s)

YF WONG, A ROSS, C MCCOLL, S MASSALAS, E POWNEY, I FINKELSTEIN, M CLARK, K HORNE, SF BERKOVIC, J DRAGO
The effect of paraformaldehyde fixation and sucrose cryoprotection on metal concentration in murine neurological tissue (vol 29, pg 565, 2014)

Journal

Journal Of Analytical Atomic Spectrometry

Volume

29

Begin Page

1726

Date

1/9/N/A

Author(s)

Dominic J Hare, Jessica L George, Lisa Bray, Irene Volitakis, Angela Vais, Timothy M Ryan, Robert A Cherny, Ashley I Bush, Colin L Masters, Paul A Adlard, Philip A Doble, David I Finkelstein
Analogues of desferrioxamine B designed to attenuate iron-mediated neurodegeneration: synthesis, characterisation and activity in the MPTP-mouse model of Parkinson's disease

Journal

Metallomics

Volume

9

Begin Page

852

Date

1/7/N/A

Author(s)

Michael P Gotsbacher, Thomas J Telfer, Paul K Witting, Kay L Double, David I Finkelstein, Rachel Codd
A mechanism for neurodegenerative disease in the enteric nervous system

Journal

Journal Of Neurochemistry

Volume

134

Begin Page

338

Date

1/8/N/A

Author(s)

V Lawson, L Ellett, LW Hung, A Quattrocelli, R Schregle, E Chan, R Munckton, A Grubman, J Furness, A White, D Finkelstein, K Barnham
Trehalose Improves Cognition in the Transgenic Tg2576 Mouse Model of Alzheimer's Disease

Journal

Journal Of Alzheimers Disease

Volume

60

Begin Page

549

Date

1/1/N/A

Author(s)

Stuart D Portbury, Dominic J Hare, Charlotte Sgambelloni, Kali Perronnes, Ashley J Portbury, David I Finkelstein, Paul A Adlard
Trehalose improves traumatic brain injury-induced cognitive impairment

Journal

Plos One

Volume

12

Begin Page

Date

24/8/N/A

Author(s)

Stuart D Portbury, Dominic J Hare, David I Finkelstein, Paul A Adlard
Isoflurane in the Aged Brain: A Link to Altered Amyloid Precursor Protein Processing

Journal

Journal Of Parkinson’s Disease & Alzheimer’s Disease

Volume

2

Begin Page

Date

N/A

Author(s)

PBT434, a novel 8-hydroxyquinazolinone, preserves nigro-striatal circuitry, improves motor performance and inhibits alpha synuclein accumulation in animal models of Parkinson's disease by modulation of iron homeostasis

Journal

Movement Disorders

Volume

28

Begin Page

S369

Date

1/6/N/A

Author(s)

DI Finkelstein, JL George, PA Adlard, CL Masters, DJ Hare, PA Doble, E Gautier, J Parsons, G Kok, P Huggins, KJ Barnham, AI Bush, RA Cherny
In vivo prion models and the disconnection between transmissibility and neurotoxicity

Journal

Ageing Research Reviews

Volume

36

Begin Page

156

Date

1/7/N/A

Author(s)

Matteo Senesi, Victoria Lewis, Jee H Kim, Paul A Adlard, David I Finkelstein, Steven J Collins
The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease

Journal

Acta Neuropathologica Communications

Volume

5

Begin Page

Date

28/6/N/A

Author(s)

David I Finkelstein, Jessica L Billings, Paul A Adlard, Scott Ayton, Amelia Sedjahtera, Colin L Masters, Simon Wilkins, David M Shackleford, Susan A Charman, Wojciech Bal, Izabela A Zawisza, Ewa Kurowska, Andrew L Gundlach, Sheri Ma, Ashley I Bush, Dominic J Hare, Philip A Doble, Simon Crawford, Elisabeth CL Gautier, Jack Parsons, Penny Huggins, Kevin J Barnham, Robert A Cherny
Prion acute synaptotoxicity at the CA1 region of the stratum radiatum

Journal

Prion

Volume

10

Begin Page

S33

Date

1/1/N/A

Author(s)

Simote T Foliaki, Victoria Lewis, David I Finkelstein, Paul A Adlard, Victoria Lawson, Steven J Collins
Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging (vol 6, pg 5383, 2015)

Journal

Chemical Science

Volume

7

Begin Page

6576

Date

1/1/N/A

Author(s)

Bence Paul, Dominic J Hare, David P Bishop, Chad Paton, Tran Nguyen Van, Nerida Cole, Megan M Niedwiecki, Erica Andreozzi, Angela Vais, Jessica L Billings, Lisa Bray, Ashley I Bush, Gawain McColl, Blaine R Roberts, Paul A Adlard, David I Finkelstein, John Hellstrom, Janet M Hergt, Jon D Woodhead, Philip A Doble
Metals in Alzheimer's and Parkinson's Disease: Relevance to Dementia with Lewy Bodies

Journal

Journal Of Molecular Neuroscience

Volume

60

Begin Page

279

Date

1/11/N/A

Author(s)

Erin J McAllum, David I Finkelstein
Transferrin protects against Parkinsonian neurotoxicity and is deficient in Parkinson’s substantia nigra

Journal

Signal Transduction And Targeted Therapy

Volume

1

Begin Page

279

Date

2/9/N/A

Author(s)

S Ayton, P Lei, C Mclean, A Bush, DI Finkelstein
Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson's disease.

Journal

Npj Parkinsons Dis

Volume

3

Begin Page

1

Date

N/A

Author(s)

Dominic J Hare, Bárbara Rita Cardoso, Erika P Raven, Kay L Double, David I Finkelstein, Ewa A Szymlek-Gay, Beverley-Ann Biggs
Age modulates the injury-induced metallomic profile in the brain

Journal

Metallomics

Volume

9

Begin Page

402

Date

1/4/N/A

Author(s)

Stuart D Portbury, Dominic J Hare, Charlotte J Sgambelloni, David P Bishop, David I Finkelstein, Philip A Doble, Paul A Adlard
Pramipexole restores depressed transmission in the ventral hippocampus following MPTP-lesion

Journal

Scientific Reports

Volume

7

Begin Page

Date

14/3/N/A

Author(s)

Javier Castro-Hernandez, Paul A Adlard, David I Finkelstein
Ferroptosis and cell death mechanisms in Parkinson's disease

Journal

Neurochemistry International

Volume

104

Begin Page

34

Date

1/3/N/A

Author(s)

Stephanie J Guiney, Paul A Adlard, Ashley I Bush, David I Finkelstein, Scott Ayton
Implantable amyloid hydrogels for promoting stem cell differentiation to neurons

Journal

Npg Asia Materials

Volume

8

Begin Page

Date

1/9/N/A

Author(s)

Subhadeep Das, Kun Zhou, Dhiman Ghosh, Narendra N Jha, Pradeep K Singh, Reeba S Jacob, Claude C Bernard, David I Finkelstein, John S Forsythe, Samir K Maji
Type-1 Interferons Contribute to the Neuroinflammatory Response and Disease Progression of the MPTP Mouse Model of Parkinson's Disease

Journal

Glia

Volume

64

Begin Page

1590

Date

1/9/N/A

Author(s)

Bevan S Main, Moses Zhang, Kate M Brody, Scott Ayton, Tony Frugier, David Steer, David Finkelstein, Peter J Crack, Juliet M Taylor

To improve loading times, 1/8 pages of publications are being displayed Click here to load all of this researcher's publications.