Staff Directory

Dr Simon Drew

Laboratory Head, Biophysics Laboratory — Neurodegeneration

Dr Drew's research aims to characterise the properties of proteins involved in neurodegenerative diseases, including their interaction with metal ions, membranes and free radicals. By first studying model systems in detail, hypotheses are generated regarding biological function that are tested in vitro and in vivo. Dr Drew graduated with a PhD in physics in 2002 under a Monash Graduate Scholarship, followed by postdoctoral training in medical imaging (MRI) from 2002ā€“2004 and bioinorganic chemistry (2004ā€“2006) at the University of Queensland. From 2006ā€“2009 he worked as research fellow in the Department of Pathology, The University of Melbourne, then as a postdoctoral fellow at the Max Planck Institute for Bioinorganic Chemistry, Germany, from 2010-2011. He is currently an ARC Future Fellow.

Research Papers

Listed below are Dr Simon Drew's most recent publications.

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N/A


In vivo-near infrared imaging of neurodegeneration

Journal

Not Found

Volume

1658

Begin Page

253

Date

1/1/N/A

Author(s)

VA Lawson, C Tumpach, CL Haigh, SC Drew
Electron paramagnetic resonance microscopy using spins in diamond under ambient conditions

Journal

Nature Communications

Volume

8

Begin Page

Date

6/9/N/A

Author(s)

David A Simpson, Robert G Ryan, Liam T Hall, Evgeniy Panchenko, Simon C Drew, Steven Petrou, Paul S Donnelly, Paul Mulvaney, Lloyd CL Hollenberg
The Case for Abandoning Therapeutic Chelation of Copper Ions Alzheimer's Disease

Journal

Frontiers In Neuroscience

Volume

11

Begin Page

Date

2/6/N/A

Author(s)

Simon C Drew
Systematically Studying the Effect of Fluoride on the Properties of Cyclophanes Bearing Naphthalene Diimide and Dialkoxyaryl Groups

Journal

Chemistry-an Asian Journal

Volume

12

Begin Page

1668

Date

4/7/N/A

Author(s)

Nicholas A Young, Simon C Drew, Subashani Maniam, Steven J Langford
Tuning the Redox Properties of Copper(II) Complexes with Amyloid-beta Peptides

Journal

Journal Of The Electrochemical Society

Volume

163

Begin Page

G196

Date

1/1/N/A

Author(s)

Magdalena Z Wiloch, Urszula E Wawrzyniak, Iwona Ufnalska, Arkadiusz Bonna, Wojciech Bal, Simon C Drew, Wojciech Wroblewskia
Interactions of alpha-Factor-1, a Yeast Pheromone, and Its Analogue with Copper(II) Ions and Low-Molecular-Weight Ligands Yield Very Stable Complexes

Journal

Inorganic Chemistry

Volume

55

Begin Page

7829

Date

15/8/N/A

Author(s)

Karolina Bossak, Mariusz Mital, Jaroslaw Poznanski, Arkadiusz Bonna, Simon Drew, Wojciech Bal
Copper Exchange and Redox Activity of a Prototypical 8-Hydroxyquinoline: Implications for Therapeutic Chelation

Journal

Inorganic Chemistry

Volume

55

Begin Page

7317

Date

1/8/N/A

Author(s)

Mariusz Mital, Izabela A Zawisza, Magdalena Z Wiloch, Urszula E Wawrzyniak, Vijaya Kenche, Wojciech Wroblewski, Wojciech Bal, Simon C Drew
Resistance of Cu(A beta 4-16) to Copper Capture by Metallothionein-3 Supports a Function for the A beta 4-42 Peptide as a Synaptic Cu-II Scavenger

Journal

Angewandte Chemie-international Edition

Volume

55

Begin Page

8235

Date

11/7/N/A

Author(s)

Nina E Wezynfeld, Ewelina Stefaniak, Kinga Stachucy, Agnieszka Drozd, Dawid Plonka, Simon C Drew, Artur Krezel, Wojciech Bal
A 2-Substituted 8-Hydroxyquinoline Stimulates Neural Stem Cell Proliferation by Modulating ROS Signalling

Journal

Cell Biochemistry And Biophysics

Volume

74

Begin Page

297

Date

1/9/N/A

Author(s)

Cathryn L Haigh, Carolin Tumpach, Steven J Collins, Simon C Drew
Removal of a cysteine ligand from rubredoxin: assembly of Fe2S2 and Fe(S-Cys)3(OH) centres

Journal

Journal Of Biological Inorganic Chemistry

Volume

7

Begin Page

781

Date

N/A

Author(s)

M CROSS, Z XIAO, EM MAES, RS CZERNUSZEWICZ, SC DREW, JR PILBROW, GN GEORGE, AG WEDD
Copper-mediated Amyloid-beta toxicity Is Associated with an Intermolecular Histidine Bridge

Journal

Journal Of Biological Chemistry

Volume

281

Begin Page

15145

Date

N/A

Author(s)

D SMITH, DG SMITH, C CURTAIN, F Boas, R Pilbrow, G CICCOTOSTO, TL LAU, D TEW, K PEREZ, J WADE, A BUSH, C Drew, F SEPAROVIC, C MASTERS, R CAPPAI, K BARNHAM
Probing the quaternary structure of metal-bridged peptide oligomers

Journal

Journal Of Inorganic Biochemistry

Volume

158

Begin Page

30

Date

1/5/N/A

Author(s)

Simon C Drew
On the ability of CuA beta(1-x) peptides to form ternary complexes: Neurotransmitter glutamate is a competitor while not a ternary partner

Journal

Journal Of Inorganic Biochemistry

Volume

158

Begin Page

5

Date

1/5/N/A

Author(s)

Tomasz Fraczyk, Izabela A Zawisza, Wojciech Goch, Ewelina Stefaniak, Simon C Drew, Wojciech Bal
Biophysical investigations of the prion protein using electron paramagnetic resonance

Journal

Methods In Molecular Biology

Volume

459

Begin Page

173

Date

1/1/N/A

Author(s)

SC Drew, KJ Barnham
The Prion Protein N1 and N2 Cleavage Fragments Bind to Phosphatidylserine and Phosphatidic Acid; Relevance to Stress-Protection Responses

Journal

Plos One

Volume

10

Begin Page

Date

7/8/N/A

Author(s)

Cathryn L Haigh, Carolin Tumpach, Simon C Drew, Steven J Collins
The N Terminus of alpha-Synuclein Forms Cu-II-Bridged Oligomers

Journal

Chemistry-a European Journal

Volume

21

Begin Page

7111

Date

4/5/N/A

Author(s)

Simon C Drew
Stable Radical Content and Anti-Radical Activity of Roasted Arabica Coffee: From In-Tact Bean to Coffee Brew

Journal

Plos One

Volume

10

Begin Page

Date

9/4/N/A

Author(s)

Gordon J Troup, Luciano Navarini, Furio Suggi Liverani, Simon C Drew
The prion protein regulates beta-amyloid-mediated self-renewal of neural stem cells in vitro

Journal

Stem Cell Research & Therapy

Volume

6

Begin Page

Date

11/4/N/A

Author(s)

Steven J Collins, Carolin Tumpach, Qiao-Xin Li, Victoria Lewis, Timothy M Ryan, Blaine Roberts, Simon C Drew, Victoria A Lawson, Cathryn L Haigh
alpha-Synuclein and beta-Amyloid form a Bridged Copper Complex

Journal

Applied Magnetic Resonance

Volume

46

Begin Page

1041

Date

1/9/N/A

Author(s)

Simon C Drew
Cavitation during the protein misfolding cyclic amplification (PMCA) method - The trigger for de novo prion generation?

Journal

Biochemical And Biophysical Research Communications

Volume

461

Begin Page

494

Date

5/6/N/A

Author(s)

Cathryn L Haigh, Simon C Drew
A Functional Role for A in Metal Homeostasis? N-Truncation and High-Affinity Copper Binding

Journal

Angewandte Chemie-international Edition

Volume

54

Begin Page

10460

Date

1/9/N/A

Author(s)

Mariusz Mital, Nina E Wezynfeld, Tomasz Fraczyk, Magdalena Z Wiloch, Urszula E Wawrzyniak, Arkadiusz Bonna, Carolin Tumpach, Kevin J Barnham, Cathryn L Haigh, Wojciech Bal, Simon C Drew
Cu2+ Coordination of Covalently Cross-linked beta-Amyloid Dimers (vol 44, pg 927, 2013)

Journal

Applied Magnetic Resonance

Volume

45

Begin Page

621

Date

1/6/N/A

Author(s)

Simon C Drew, W Mei Kok, Craig A Hutton, Kevin J Barnham
Development of a neuroprotective antioxidant by a mix-and-match strategy

Journal

Oxidants And Antioxidants In Medical Science

Volume

2

Begin Page

255

Date

N/A

Author(s)

Vijaya Kenche, Carolin Tumpach, Kevin Barnham, Steven Collins, Cathryn Haigh, Simon Drew
Neutron Reflectometry Studies Define Prion Protein N-terminal Peptide Membrane Binding

Journal

Biophysical Journal

Volume

107

Begin Page

2313

Date

18/11/N/A

Author(s)

Anton P Le Brun, Cathryn L Haigh, Simon C Drew, Michael James, Martin P Boland, Steven J Collins

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Qualifications

Listed below are Dr Simon Drew's qualifications.
  • BSc(hons)
  • PhD