Staff Directory

Prof Steven Collins

Steven Collins is a neurologist-scientist, who over the last 20 years has predominantly researched prion diseases, thereby developing extensive clinico-epidemiological and basic scientific research experience in prion diseases in parallel with developing his own independent teams dedicated to studying prion disease epidemiology, as well as undertaking basic scientific research relating to normal prion protein cell biology and prion pathogenesis. Over the 20 years of prion disease research Prof Collins has supervised numerous post-graduate students and mentored early and mid-career scientists, and established numerous international collaborations, especially for epidemiological research, often taking the lead role in multi-national research, with output from clinico-epidemiological research published in high quality journals such as Lancet, Nature Medicine, Annals of Neurology, Brain, Alzheimer’s & Dementia and The American Journal of Human Genetics. The clinico-epidemiological research has emphasised assessment and validation of biomarkers often prompting revision of consensus diagnostic criteria for epidemiological research and clinical evaluation. Prof Collins has recently extended his interest in diagnostic biomarkers into Alzheimer’s disease (AD), as well as participation in AD clinical trials. As a consequence of his interest and experience in diagnostic biomarkers, Prof Collins is now Director of two national NATA accredited diagnostic laboratories. Prof Collins also has considerable experience in the use of rodent models to study prion diseases, including more sophisticated techniques such as stereotaxic surgery and gross motor, behavioural and cognitive assessment paradigms.

Research Papers

Listed below are Prof Steven Collins's most recent publications.

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Integrated genomic and proteomic analyses of gene expression in mammalian cells

Journal

Molecular And Cellular Proteomics

Volume

3

Begin Page

960

Date

1/10/N/A

Author(s)

Q Tian, SB Stepaniants, M Mao, L Weng, MC Feetham, MJ Doyle, EC Yi, H Dai, V Thorsson, J Eng, D Goodlett, JP Berger, B Gunter, PS Linseley, RB Stoughton, R Aebersold, SJ Collins, WA Hanlon, LE Hood
Activated Ca2+/calmodulin-dependent protein kinase IIγ is a critical regulator of myeloid leukemia cell proliferation

Journal

Cancer Research

Volume

68

Begin Page

3733

Date

15/5/N/A

Author(s)

J Si, SJ Collins
Retinoic acid receptors, hematopoiesis and leukemogenesis

Journal

Current Opinion In Hematology

Volume

15

Begin Page

346

Date

1/7/N/A

Author(s)

SJ Collins
Peroxisome proliferator-activated receptor and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias

Journal

Molecular Cancer Therapeutics

Volume

3

Begin Page

1249

Date

1/10/N/A

Author(s)

M Konopleva, E Elstner, TJ McQueen, T Tsao, A Sudarikov, W Hu, WD Schober, RY Wang, D Chism, SM Kornblau, A Younes, SJ Collins, HP Koeffler, M Andreeff
The retinoic acid receptor/CaMKII interaction: Pharmacologic inhibition of CaMKII enhances the differentiation of myeloid leukemia cells

Journal

Blood Cells, Molecules, And Diseases

Volume

39

Begin Page

307

Date

1/11/N/A

Author(s)

J Si, LM Mueller, A Schuler, J Simon, SJ Collins
CaMKII regulates retinoic acid receptor transcriptional activity and the differentiation of myeloid leukemia cells

Journal

Journal Of Clinical Investigation

Volume

117

Begin Page

1412

Date

1/5/N/A

Author(s)

J Si, LM Mueller, SJ Collins
Retinoic acid receptors in hematopoiesis

Journal

Current Topics In Microbiology And Immunology

Volume

211

Begin Page

6

Date

1/12/N/A

Author(s)

SJ Collins, S Tsai, I Bernstein
MEK blockade converts AML differentiating response to retinoids into extensive apoptosis

Journal

Blood

Volume

109

Begin Page

2121

Date

1/3/N/A

Author(s)

M Milella, M Konopleva, CM Precupanu, Y Tabe, MR Ricciardi, C Gregorj, SJ Collins, BZ Carter, C D'Angelo, MT Petrucci, R Foà, F Cognetti, A Tafuri, M Andreeff
Different mechanisms account for the relative resistance of KG-1 and HL-60 cell lines to retrovirus infection

Journal

Journal Of Virology

Volume

62

Begin Page

4346

Date

1/1/N/A

Author(s)

SJ Collins
Multiple Members of the Retinoic Acid Receptor Family Are Capable of Mediating the Granulocytic Differentiation of HL-60 Cells

Journal

Molecular And Cellular Biology

Volume

12

Begin Page

3743

Date

1/1/N/A

Author(s)

KA Robertson, B Emami, L Mueller, SJ Collins
The cytokines IL-3 and GM-CSF regulate the transcriptional activity of retinoic acid receptors in different in vitro models of myeloid differentiation

Journal

Blood

Volume

99

Begin Page

746

Date

1/2/N/A

Author(s)

BS Johnson, L Mueller, J Si, SJ Collins
Alterations of differentiation, clonal proliferation, cell cycle progression and bcl-2 expression in RARα-altered sublines of HL-60

Journal

Leukemia

Volume

11

Begin Page

393

Date

28/3/N/A

Author(s)

I Grillier, T Umiel, E Elstner, SJ Collins, HP Koeffler
Proteins associated with cisplatin resistance in ovarian cancer cells identified by quantitative proteomic technology and integrated with mRNA expression levels

Journal

Molecular And Cellular Proteomics

Volume

5

Begin Page

433

Date

1/3/N/A

Author(s)

JJ Stewart, JT White, X Yan, S Collins, CW Drescher, ND Urban, L Hood, B Lin
Integration of cytogenetic landmarks into the draft sequence of the human genome

Journal

Nature

Volume

409

Begin Page

953

Date

15/2/N/A

Author(s)

VG Cheung, N Nowak, W Jang, IR Kirsch, S Zhao, XN Chen, TS Furey, UJ Kim, WL Kuo, M Olvier, J Conroy, A Kasprzyk, H Massa, R Yonescu, S Sait, C Thoreen, A Snijders, E Lemyre, JA Bailey, A Bruzel, WD Burrill, SM Clegg, S Collins, P Dhami, C Friedman, CS Han, S Herrick, J Lee, AH Ligon, S Lowry, M Moriey, S Narasimhan, K Osoegawa, Z Peng, I Plajzer-Frick, BJ Quade, D Scott, K Sirotkin, AA Thorpe, JW Gray, J Hudson, D Pinkel, T Ried, L Rowen, GL Shen-Ong, RL Strausberg, E Birney, DF Callen, JF Cheng, DR Cox, NA Doggett, NP Carter, EE Eichler, D Haussler, JR Korenberg, CC Morton, D Albertson, G Schuler, PJ De Jong, BJ Trask
Retinoic acid and 4-hydroxyphenylretinamide induce growth inhibition and tissue transglutaminase through different signal transduction pathways in mouse fibroblasts (NIH 3T3 cells)

Journal

Carcinogenesis

Volume

20

Begin Page

1133

Date

17/6/N/A

Author(s)

V Giandomenico, F Andreola, ML Rodriguez De La Concepcion, SJ Collins, LM De Luca
KN-62 analogues as potent differentiating agents of HL-60 cells

Journal

Leukemia Research

Volume

31

Begin Page

683

Date

1/5/N/A

Author(s)

AD Schuler, J Si, LM Mueller, JA Simon, SJ Collins
Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture

Journal

Nature

Volume

270

Begin Page

347

Date

1/12/N/A

Author(s)

SJ Collins, RC Gallo, RE Gallagher
CLONAL NATURE OF SPONTANEOUS AKR LEUKEMIA: STUDIES UTILIZING THE X‐LINKED ENZYME PHOSPHOGLYCERATE KINASE

Journal

International Journal Of Cancer

Volume

29

Begin Page

673

Date

1/1/N/A

Author(s)

SJ Collins, PJ Fialkow
Rearrangement and amplification of c-abl sequences in the human chronic myelogenous leukemia cell line K-562

Journal

Proceedings Of The National Academy Of Sciences Of The United States Of America

Volume

80

Begin Page

4813

Date

1/12/N/A

Author(s)

SJ Collins, MT Groudine
Altered transcription of the c-abl oncogene in K-562 and other chronic myelogenous leukemia cells

Journal

Science

Volume

225

Begin Page

72

Date

1/1/N/A

Author(s)

SJ Collins, I Kubonishi, I Miyoshi, MT Groudine
Cyclins, Cdks, and cyclin kinase inhibitors

Journal

Cold Spring Harbor Symposia On Quantitative Biology

Volume

59

Begin Page

31

Date

1/12/N/A

Author(s)

JM Roberts, A Koff, K Polyak, E Firpo, S Collins, M Ohtsubo, J Massague
N-ras mutations in acute myelogenous leukemia: A review of the Current literature and an update of the southwest oncology group experience

Journal

Leukemia And Lymphoma

Volume

6

Begin Page

325

Date

1/1/N/A

Author(s)

JP Radich, KJ Kopecky, F Appelbaum, CL Willman, SJ Collins
N-ras mutations in adult de novo acute myelogenous leukemia: Prevalence and clinical significance

Journal

Blood

Volume

76

Begin Page

801

Date

1/1/N/A

Author(s)

JP Radich, KJ Kopecky, CL Willman, J Weick, D Head, F Appelbaum, SJ Collins
Paclitaxel plus carboplatin versus standard chemotherapy with either single-agent carboplatin or cyclophosphamide, doxorubicin, and cisplatin in women with ovarian cancer: The ICON3 randomised trial

Journal

Lancet

Volume

360

Begin Page

505

Date

17/8/N/A

Author(s)

MKB Parmar, M Adams, M Balestrino, K Bertelsen, C Bonazzi, H Calvert, N Colombo, JF Delaloye, A Durando, D Guthrie, B Hagen, P Harper, C Mangioni, T Perren, C Poole, W Qian, G Rustin, J Sandercock, S Tumolo, V Torri, F Vecchione, A Tinazzi, B Uscinska, S Collins, M Flann, A Buda, B Taylor, I Tannock, R Souhami, M Grazia-Valsecchi

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