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Staff Directory

Prof Ashley Bush MB BS, DPM, FRANZCP, PhD, FTSE, FAHMS, FAPA

Head, Oxidation Biology Unit — Melbourne Dementia Research Centre

Ashley Bush (MBBS, DPM, FRANZCP, PhD, FTSE, FAHMS, FAPA) is Professor of Neuroscience at the University of Melbourne; Director of the Oxidation Biology Unit at the Florey Institute of Neuroscience & Mental Health; Co-Director of Biomarker Development for the Australian Imaging, Biomarkers and Lifestyle Study of Aging; and Chief Scientific Officer for the Cooperative Research Centre for Mental Health. As a neuroscientist and ageing researcher, Prof Bush has made valuable contributions over the past 25 years to our understanding of the importance of metal biology and oxidative stress in the function and dysfunction of the brain, especially as it is ages and becomes predisposed to degeneration. He has accrued 360+ publications and 26 patents, has presented over 280 invited lectures worldwide (including 24 Plenary), is currently the most highly cited neuroscientist in Australia and is rated in the top 1% of neuroscience researchers worldwide for high impact citations. The steady increase in the proportion of world publications relating to metals in the brain can be largely attributed to the impact of Prof Bush’s work and his pioneering Metals Theory of Age-related Neurodegeneration. Over the course of his career, he has received several awards and honours for his research, most recently the NHMRC Australia Fellowship (2011); Victoria Prize for Science and Innovation (2014); Woodward Medal in Science and Technology (2014); NHMRC Senior Principal Research Fellowship (2016), and citation in The World's Most Influential Scientific Minds (Thomson Reuters, 2014, 2015).

Research Papers

Listed below are Prof Ashley Bush's most recent publications.

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Evidence that iron accelerates Alzheimer's pathology: a CSF biomarker study.

Journal

J Neurol Neurosurg Psychiatry

Volume

Not Found

Begin Page

Date

22/9/N/A

Author(s)

Scott Ayton, Ibrahima Diouf, Ashley Ian Bush, Alzheimer’s disease Neuroimaging Initiative
Reduction potentials of protein disulfides and catalysis of glutathionylation and deglutathionylation by glutaredoxin enzymes.

Journal

Biochem J

Volume

474

Begin Page

3799

Date

9/11/N/A

Author(s)

Ashwinie A Ukuwela, Ashley I Bush, Anthony G Wedd, Zhiguang Xiao
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Journal

Cell

Volume

171

Begin Page

273

Date

5/10/N/A

Author(s)

Brent R Stockwell, Jose Pedro Friedmann Angeli, Hulya Bayir, Ashley I Bush, Marcus Conrad, Scott J Dixon, Simone Fulda, Sergio Gascon, Stavroula K Hatzios, Valerian E Kagan, Kay Noel, Xuejun Jiang, Andreas Linkermann, Maureen E Murphy, Michael Overholtzer, Atsushi Oyagi, Gabriela C Pagnussat, Jason Park, Qitao Ran, Craig S Rosenfeld, Konstantin Salnikow, Daolin Tang, Frank M Torti, Suzy V Torti, Shinya Toyokuni, KA Woerpel, Donna D Zhang
A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort

Journal

Scientific Reports

Volume

7

Begin Page

273

Date

1/12/N/A

Author(s)

S Pedrini, VB Gupta, E Hone, J Doecke, S O'Bryant, I James, AI Bush, CC Rowe, VL Villemagne, D Ames, CL Masters, RN Martins, G Savage, B Wilson, P Bourgeat, J Fripp, S Gibson, H Leroux, S McBride, O Salvado, M Fenech, M Francois, M Barnes, J Baker, K Barnham, S Bellingham, J Bomke, SB Pejoska, R Buckley, L Cheng, S Collins, I Cooke, E Cyarto, D Darby, V Dore, D El-Sheikh, N Faux, C Fowler, K Harrington, A Hill, M Horne, G Jones, A Kamer, N Killeen, H Korrel, F Lamb, N Lautenschlager, K Lennon, QX Li, YY Lim, A Louey, L Macaulay, L Mackintosh, P Maruff, A McIlroy, J Nigro, K Perez, K Pertile, C Restrepo, BR Cardoso, A Rembach, B Roberts, J Robertson, R Rumble, T Ryan, J Sach, B Silbert, C Thai, B Trounson, I Volitakis, M Vovos, L Ward, A Watt, R Williams, M Woodward, P Yates, FY Ugarte, P Zhang, S Bird, B Brown, S Burnham, P Chatterjee, K Cox, S Fernandez, B Fernando, S Gardener, S Laws, F Lim, L Lim, M Tegg, K Lucas, G Martins
Nanoscale Imaging Reveals Big Role for Iron in Alzheimer's Disease

Journal

Cell Chemical Biology

Volume

24

Begin Page

1192

Date

19/10/N/A

Author(s)

Scott Ayton, Simon A James, Ashley I Bush
The effect of paraformaldehyde fixation and sucrose cryoprotection on metal concentration in murine neurological tissue (vol 29, pg 565, 2014)

Journal

Journal Of Analytical Atomic Spectrometry

Volume

29

Begin Page

1726

Date

1/9/N/A

Author(s)

Dominic J Hare, Jessica L George, Lisa Bray, Irene Volitakis, Angela Vais, Timothy M Ryan, Robert A Cherny, Ashley I Bush, Colin L Masters, Paul A Adlard, Philip A Doble, David I Finkelstein
Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

Journal

Molecular Psychiatry

Volume

22

Begin Page

1520

Date

1/11/N/A

Author(s)

Q-Z Tuo, P Lei, KA Jackman, X-I Li, H Xiong, X-L Li, Z-Y Liuyang, L Roisman, S-T Zhang, S Ayton, Q Wang, PJ Crouch, K Ganio, X-C Wang, L Pei, PA Adlard, Y-M Lu, R Cappai, J-Z Wang, R Liu, AI Bush
Correction: Iron Accumulates in Huntington’s Disease Neurons: Protection by Deferoxamine

Journal

Plos One

Volume

8

Begin Page

1520

Date

13/11/N/A

Author(s)

Jianfang Chen, Eileen Marks, Barry Lai, Zhaojie Zhang, James A Duce, Linh Q Lam, Irene Volitakis, Ashley I Bush, Steven Hersch, Jonathan H Fox
Business group affiliation, earnings management and audit quality: evidence from Bangladesh

Journal

Managerial Auditing Journal

Volume

32

Begin Page

427

Date

1/1/N/A

Author(s)

Mohammad Badrul Muttakin, Arifur Khan, Dessalegn Getie Mihret
Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

Journal

Redox Biology

Volume

14

Begin Page

100

Date

1/4/N/A

Author(s)

S Masaldan, SAS Clatworthy, C Gamell, PM Meggyesy, AT Rigopoulos, S Haupt, Y Haupt, D Denoyer, PA Adlard, AI Bush, MA Cater
Copper and Alzheimer disease: The good, the bad and the ugly

Journal

Not Found

Volume

Not Found

Begin Page

609

Date

1/1/N/A

Author(s)

YH Hung, AI Bush, RA Cherny
A normalisation framework for quantitative brain imaging; Application to quantitative susceptibility mapping

Journal

Proceedings - International Symposium On Biomedical Imaging

Volume

Not Found

Begin Page

97

Date

15/6/N/A

Author(s)

A Fazlollahi, S Ayton, P Bourgeat, P Raniga, A Ng, J Fripp, D Ames, CL Masters, CC Rowe, VL Villemagne, AI Bush, O Salvado
HEAVY-METALS, GENES, AND NEURODEGENERATIVE DISORDERS - WILSONS-DISEASE AND ALZHEIMERS-DISEASE

Journal

Journal Of Neurochemistry

Volume

65

Begin Page

S71

Date

1/1/N/A

Author(s)

RE TANZI, W WASCO, RD MOIR, AI BUSH
THE ROLE OF CEREBRAL ZINC-METABOLISM IN ALZHEIMERS-DISEASE A-BETA-AMYLOIDOSIS

Journal

Journal Of Neurochemistry

Volume

65

Begin Page

S9

Date

1/1/N/A

Author(s)

AI BUSH, RD MOR, K ROSENKRANZ, L RODES, RE TANZI
The role of zinc in the cerebral deposition of A beta amyloid in Alzheimer's disease

Journal

Research Advances In Alzheimer's Disease And Related Disorders

Volume

Not Found

Begin Page

607

Date

1/1/N/A

Author(s)

AI BUSH, RE TANZI
ZINC AND ALZHEIMERS-DISEASE - RESPONSE

Journal

Science

Volume

268

Begin Page

1921

Date

30/6/N/A

Author(s)

AI BUSH, RD MOIR, KM ROSENKRANZ, RE TANZI
ZINC AND MACULAR DEGENERATION

Journal

Annals Of Ophthalmology-glaucoma

Volume

27

Begin Page

194

Date

1/7/N/A

Author(s)

J HARTSTEIN, U PACE, ME HARTSTEIN, RE TANZI, AI BUSH
LDL RECEPTOR-RELATED PROTEIN (LRP) BINDS SECRETED BETA-AMYLOID PRECURSOR PROTEIN AND MEDIATES ITS DEGRADATION

Journal

Molecular Biology Of The Cell

Volume

6

Begin Page

1901

Date

1/11/N/A

Author(s)

MZ KOUNNAS, RD MOIR, GW REBECK, AI BUSH, WS ARGRAVES, RE TANZI, BT HYMAN, DK STRICKLAND
Neurochemical environments that precipitate A beta

Journal

Alzheimer's Disease: Biology, Diagnosis And Therapeutics

Volume

Not Found

Begin Page

327

Date

1/1/N/A

Author(s)

CS Atwood, XD Huang, RD Moir, RE Tanzi, AI Bush
The metabolism of the amyloid precursor protein of Alzheimer's disease and dietary zinc

Journal

Alzheimer's Disease: Biology, Diagnosis And Therapeutics

Volume

Not Found

Begin Page

417

Date

1/1/N/A

Author(s)

S Whyte, L Jones, EJ Coulson, RD Moir, AI Bush, K Beyreuther, CL Masters
Metal-catalyzed redox activity of A beta - The major source of amyloid-associated oxidative stress in Alzheimer's disease

Journal

Alzheimer's Disease And Related Disorders

Volume

Not Found

Begin Page

383

Date

1/1/N/A

Author(s)

XD Huang, CS Atwood, LE Goldstein, MA Hartshorn, AJ Saunders, RD Moir, RE Tanzi, AI Bush
Lens epithelium-derived growth factor (LEDGF) in the retina and brain.

Journal

Investigative Ophthalmology & Visual Science

Volume

41

Begin Page

S870

Date

15/3/N/A

Author(s)

LE Goldstein, E Kubo, DP Singh, AI Bush, LT Chylack, T Shinohara
CIRCULATING FORMS OF AMYLOID PRECURSOR PROTEIN OF ALZHEIMERS-DISEASE

Journal

Alzheimers Disease : Basic Mechanisms, Diagnosis And Therapeutic Strategies

Volume

Not Found

Begin Page

547

Date

1/1/N/A

Author(s)

AI BUSH, K BEYREUTHER, CL MASTERS
THE ROLE OF ZINC IN A-BETA AMYLOIDOSIS

Journal

Neurobiology Of Aging

Volume

15

Begin Page

S50

Date

1/1/N/A

Author(s)

AI BUSH, WH PETTINGELL, MD PARADIS, RE TANZI
Alzheimer's disease, beta-amyloid protein and zinc

Journal

Journal Of Nutrition

Volume

130

Begin Page

1488S

Date

1/5/N/A

Author(s)

XD Huang, MP Cuajungco, CS Atwood, RD Moir, RE Tanzi, AI Bush

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Qualifications

Listed below are Prof Ashley Bush's qualifications.
  • 1982, M.B.,B.S (Medicine), The University of Melbourne
  • 1988, Dipl Psychological Medicine, The University of Melbourne
  • 1989, Fellow, Royal Australian and New Zealand College of Psychiatrists (FRANZCP)
  • 1993, PhD (Pathology), The University of Melbourne

Awards

Listed below are Prof Ashley Bush's awards.
  • NHMRC Senior Principal Research Fellowship (2016)
  • The World's Most Influential Scientific Minds (Thomson Reuters, 2014, 2015)
  • Fellow, Australian Academy of Health and Medical Sciences (2015)
  • Fellow, American Psychiatric Association (2015)
  • The Woodward Medal in Science & Technology, University of Melbourne (2014)
  • Victoria Prize for Science & Innovation (Veski & Victorian Government, 2014)
  • NHMRC Australia Fellowship (2011)
  • The Royal Australian and New Zealand College of Psychiatrists Schering-Plough Senior Research Award (2010)
  • Fellow, The Australian Academy of Technological Sciences and Engineering (2009)
  • Flagship Fellow, CSIRO (2007)
  • Bethlehem Griffiths Research Foundation Award in Neurology (2007)
  • Zenith Fellow, Alzheimer’s Association (2004)
  • Federation Fellow, Australian Research Council (2004)
  • Potamkin Prize, American Academy of Neurology (2003)
  • Alzheimer Association Senator Mark A. Hatfield Award for Clinical Research in Alzheimer's Disease (2000-3)
  • Paul Beeson Physician Faculty Scholar in Aging, American Federation of Aging Research (1995-8)
  • Ellison Scholarship, Massachusetts General Hospital (1994-5)
  • National Down Syndrome Society Scholars Award (1994)
  • Organon Award for Psychiatric Research (1994)
  • Harkness Fellowship, Commonwealth Fund of New York (1992-3)
  • NHMRC Postgraduate Medical Scholarship (1989-92)
  • Victorian Medical Postgraduate Foundation Research Award (1986)