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Prof Ashley Bush MB BS, DPM, FRANZCP, PhD, FTSE, FAHMS, FAPA

Head, Oxidation Biology Unit — Melbourne Dementia Research Centre

Ashley Bush (MBBS, DPM, FRANZCP, PhD, FTSE, FAHMS, FAPA) is Professor of Neuroscience at the University of Melbourne; Director of the Oxidation Biology Unit at the Florey Institute of Neuroscience & Mental Health; Co-Director of Biomarker Development for the Australian Imaging, Biomarkers and Lifestyle Study of Aging; and Chief Scientific Officer for the Cooperative Research Centre for Mental Health. As a neuroscientist and ageing researcher, Prof Bush has made valuable contributions over the past 25 years to our understanding of the importance of metal biology and oxidative stress in the function and dysfunction of the brain, especially as it is ages and becomes predisposed to degeneration. He has accrued 360+ publications and 26 patents, has presented over 280 invited lectures worldwide (including 24 Plenary), is currently the most highly cited neuroscientist in Australia and is rated in the top 1% of neuroscience researchers worldwide for high impact citations. The steady increase in the proportion of world publications relating to metals in the brain can be largely attributed to the impact of Prof Bush’s work and his pioneering Metals Theory of Age-related Neurodegeneration. Over the course of his career, he has received several awards and honours for his research, most recently the NHMRC Australia Fellowship (2011); Victoria Prize for Science and Innovation (2014); Woodward Medal in Science and Technology (2014); NHMRC Senior Principal Research Fellowship (2016), and citation in The World's Most Influential Scientific Minds (Thomson Reuters, 2014, 2015).

Research Papers

Listed below are Prof Ashley Bush's most recent publications.

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What can predict and prevent the long-term use of benzodiazepines?

Journal

Journal Of Psychiatric Research

Volume

97

Begin Page

94

Date

1/2/N/A

Author(s)

T Hata, T Kanazawa, T Hamada, M Nishihara, AI Bush, H Yoneda, M Nakajima, T Katsumata
Concordance Between Cerebrospinal Fluid Biomarkers with Alzheimer's Disease Pathology Between Three Independent Assay Platforms

Journal

Journal Of Alzheimers Disease

Volume

61

Begin Page

169

Date

1/1/N/A

Author(s)

James D Doecke, Alan Rembach, Victor L Villemagne, Shiji Varghese, Stephanie Rainey-Smith, Shannon Sarros, Lisbeth A Evered, Christopher J Fowler, Kelly K Pertile, Rebecca L Rumble, Brett Trounson, Kevin Taddei, Simon M Laws, S Lance Macaulay, Ashley I Bush, Kathryn A Ellis, Ralph Martins, David Ames, Brendan Silbert, Hugo Vanderstichele, Colin L Masters, David G Darby, Qiao-Xin Li, Steven Collins
The Role of Selenium in Neurodegenerative Diseases

Journal

Not Found

Volume

Not Found

Begin Page

35

Date

1/1/N/A

Author(s)

Barbara R Cardoso, Dominic J Hare, Ashley I Bush
Metalloregulation of Protein Clearance: New Therapeutic Avenues for Neurodegenerative Diseases

Journal

Not Found

Volume

Not Found

Begin Page

363

Date

1/1/N/A

Author(s)

Alejandra Ramirez Munoz, Mark A Greenough, Ashley I Bush, Carlos M Opazo
Editorial: The CB2 Cannabinoid System: A New Strategy in Neurodegenerative Disorder and Neuroinflammation

Journal

Frontiers In Neuroscience

Volume

11

Begin Page

363

Date

6/4/N/A

Author(s)

Marialessandra Contino, Elena Capparelli, Nicola A Colabufo, Ashley I Bush
The Aβ peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction

Journal

Biochemistry

Volume

38

Begin Page

363

Date

15/6/N/A

Author(s)

X Huang, CS Atwood, MA Hartshorn, G Multhaup, LE Goldstein, RC Scarpa, MP Cuajungco, DN Gray, J Lim, RD Moir, RE Tanzi, AI Bush
Is ALS caused by an altered oxidative activity of mutant superoxide dismutase?

Journal

Nature Neuroscience

Volume

5

Begin Page

919

Date

N/A

Author(s)

AI BUSH
Alzheimer disease beta-amyloid activity mimics cholesterol oxidase (vol 116, pg 2828, 2006)

Journal

Journal Of Clinical Investigation

Volume

116

Begin Page

2828

Date

1/10/N/A

Author(s)

Luigi Puglielli, Avi L Friedlich, Kenneth DR Setchell, Seiichi Nagano, Carlos Opazo, Robert A Cherny, Kevin J Barnham, John D Wade, Simon Melov, Dora M Kovacs, Ashley I Bush
Metal chaperones: a holistic approach to the treatment of Alzheimer's disease

Journal

Frontiers In Psychiatry

Volume

3

Begin Page

15

Date

N/A

Author(s)

PA Adlard, AI Bush
Physical activity and amyloid-β plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing

Journal

Molecular Psychiatry

Volume

18

Begin Page

875

Date

N/A

Author(s)

BM Brown, JJ Peiffer, K Taddei, JK Lui, SM Laws, VB Gupta, T Taddei, VK Ward, MA Rodrigues, S Burnham, SR Rainey-Smith, VL Villemagne, AI Bush, KA Ellis, CL Masters, DJ Ames, SL Macaulay, C Szoeke, CC Rowe, RN Martins
Erratum: The AIBL Investigators. Increased risk of cognitive impairment in patients with diabetes is associated with metformin (Diabetes Care (2013) 36 (2981-2987))

Journal

Diabetes Care

Volume

36

Begin Page

3850

Date

1/11/N/A

Author(s)

EM Moore, AG Mander, D Ames, MA Kotowicz, RP Carne, H Brodaty, M Woodward, K Boundy, KA Ellis, AI Bush, NG Faux, R Martins, C Szoeke, C Rowe, DA Watters
Erratum: The effect of paraformaldehyde fixation and sucrose cryoprotection on metal concentration in murine neurological tissue (Journal of Analytical Atomic Spectrometry (2013) DOI: 10.1039/C3JA50281C)

Journal

Journal Of Analytical Atomic Spectrometry

Volume

29

Begin Page

1726

Date

1/1/N/A

Author(s)

DJ Hare, JL George, L Bray, I Volitakis, A Vais, TM Ryan, RA Cherny, AI Bush, CL Masters, PA Adlard, PA Doble, DI Finkelstein
Erratum: Ï †xANES: In vivo imaging of metal-protein coordination environments (Scientific Reports (2016) 6 (20350) DOI: 10.1038/srep20350)

Journal

Scientific Reports

Volume

6

Begin Page

1726

Date

21/3/N/A

Author(s)

SA James, DJ Hare, NL Jenkins, MD De Jonge, AI Bush, G McColl
Upregulation of zinc transporter, solute carrier family 39, member 12, in the cortex of subjects with schizophrenia

Journal

International Journal Of Neuropsychopharmacology

Volume

19

Begin Page

227

Date

1/6/N/A

Author(s)

M Udawela, B Dean, M Greenough, T Money, MS Seo, A Bush, E Scarr
Metal Complexing Agents for the Treatment of Alzheimer's Disease

Journal

Not Found

Volume

2

Begin Page

107

Date

1/1/N/A

Author(s)

Anthony R White, Ashley I Bush
Zinc and Alzheimer's Disease

Journal

Not Found

Volume

76

Begin Page

417

Date

1/1/N/A

Author(s)

Paul A Adlard, Ashley I Bush
Biological Metals: Metallostasis and Alzheimer's Disease

Journal

Not Found

Volume

Not Found

Begin Page

152

Date

1/1/N/A

Author(s)

A Rembach, JA Duce, LA O'Sullivan, RE Tanzi, AI Bush
The Role of the Plasma Membrane Redox System in the Pathogenesis of Alzheimer's Disease

Journal

Not Found

Volume

Not Found

Begin Page

55

Date

1/1/N/A

Author(s)

Sara M Hancock, David I Finkelstein, Ashley I Bush, Paul A Adlard
S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency

Journal

Journal Of Clinical Investigation

Volume

127

Begin Page

4365

Date

1/12/N/A

Author(s)

Avadh Kumar, Borislav Dejanovic, Florian Hetsch, Marcus Semtner, Debora Fusca, Sita Arjune, Jose Angel Santamaria-Araujo, Aline Winkelmann, Scott Ayton, Ashley I Bush, Peter Kloppenburg, Jochen C Meier, Guenter Schwarz, Abdel Ali Belaidi
Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging (vol 6, pg 5383, 2015)

Journal

Chemical Science

Volume

6

Begin Page

6677

Date

1/1/N/A

Author(s)

Bence Paul, Dominic J Hare, David P Bishop, Chad Paton, Tran Nguyen Van, Nerida Cole, Megan M Niedzwiecki, Erica Andreozzi, Angela Vais, Jessica L Billings, Lisa Bray, Ashley I Bush, Gawain McColl, Blaine R Roberts, Paul A Adlard, David I Finkelstein, John Hellstrom, Janet M Hergt, Jon D Woodhead, Philip A Doble
Evidence that iron accelerates Alzheimer's pathology: a CSF biomarker study.

Journal

J Neurol Neurosurg Psychiatry

Volume

Not Found

Begin Page

6677

Date

22/9/N/A

Author(s)

Scott Ayton, Ibrahima Diouf, Ashley Ian Bush, Alzheimer’s disease Neuroimaging Initiative
Reduction potentials of protein disulfides and catalysis of glutathionylation and deglutathionylation by glutaredoxin enzymes

Journal

Biochemical Journal

Volume

474

Begin Page

3799

Date

15/11/N/A

Author(s)

Ashwinie A Ukuwela, Ashley I Bush, Anthony G Wedd, Zhiguang Xiao
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Journal

Cell

Volume

171

Begin Page

273

Date

5/10/N/A

Author(s)

Brent R Stockwell, Jose Pedro Friedmann Angeli, Hulya Bayir, Ashley I Bush, Marcus Conrad, Scott J Dixon, Simone Fulda, Sergio Gascon, Stavroula K Hatzios, Valerian E Kagan, Kay Noel, Xuejun Jiang, Andreas Linkermann, Maureen E Murphy, Michael Overholtzer, Atsushi Oyagi, Gabriela C Pagnussat, Jason Park, Qitao Ran, Craig S Rosenfeld, Konstantin Salnikow, Daolin Tang, Frank M Torti, Suzy V Torti, Shinya Toyokuni, KA Woerpel, Donna D Zhang
A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of beta-amyloid load in an AD cohort

Journal

Scientific Reports

Volume

7

Begin Page

Date

25/10/N/A

Author(s)

Steve Pedrini, Veer B Gupta, Eugene Hone, James Doecke, Sid O'Bryant, Ian James, Ashley I Bush, Christopher C Rowe, Victor L Villemagne, David Ames, Colin L Masters, Ralph N Martins
Nanoscale Imaging Reveals Big Role for Iron in Alzheimer's Disease

Journal

Cell Chemical Biology

Volume

24

Begin Page

1192

Date

19/10/N/A

Author(s)

Scott Ayton, Simon A James, Ashley I Bush

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Qualifications

Listed below are Prof Ashley Bush's qualifications.
  • 1982, M.B.,B.S (Medicine), The University of Melbourne
  • 1988, Dipl Psychological Medicine, The University of Melbourne
  • 1989, Fellow, Royal Australian and New Zealand College of Psychiatrists (FRANZCP)
  • 1993, PhD (Pathology), The University of Melbourne

Awards

Listed below are Prof Ashley Bush's awards.
  • NHMRC Senior Principal Research Fellowship (2016)
  • The World's Most Influential Scientific Minds (Thomson Reuters, 2014, 2015)
  • Fellow, Australian Academy of Health and Medical Sciences (2015)
  • Fellow, American Psychiatric Association (2015)
  • The Woodward Medal in Science & Technology, University of Melbourne (2014)
  • Victoria Prize for Science & Innovation (Veski & Victorian Government, 2014)
  • NHMRC Australia Fellowship (2011)
  • The Royal Australian and New Zealand College of Psychiatrists Schering-Plough Senior Research Award (2010)
  • Fellow, The Australian Academy of Technological Sciences and Engineering (2009)
  • Flagship Fellow, CSIRO (2007)
  • Bethlehem Griffiths Research Foundation Award in Neurology (2007)
  • Zenith Fellow, Alzheimer’s Association (2004)
  • Federation Fellow, Australian Research Council (2004)
  • Potamkin Prize, American Academy of Neurology (2003)
  • Alzheimer Association Senator Mark A. Hatfield Award for Clinical Research in Alzheimer's Disease (2000-3)
  • Paul Beeson Physician Faculty Scholar in Aging, American Federation of Aging Research (1995-8)
  • Ellison Scholarship, Massachusetts General Hospital (1994-5)
  • National Down Syndrome Society Scholars Award (1994)
  • Organon Award for Psychiatric Research (1994)
  • Harkness Fellowship, Commonwealth Fund of New York (1992-3)
  • NHMRC Postgraduate Medical Scholarship (1989-92)
  • Victorian Medical Postgraduate Foundation Research Award (1986)