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Prof Ashley Bush MB BS, DPM, FRANZCP, PhD, FTSE, FAHMS, FAPA

Head, Oxidation Biology Unit — Melbourne Dementia Research Centre

Ashley Bush (MBBS, DPM, FRANZCP, PhD, FTSE, FAHMS, FAPA) is Professor of Neuroscience at the University of Melbourne; Director of the Oxidation Biology Unit at the Florey Institute of Neuroscience & Mental Health; Co-Director of Biomarker Development for the Australian Imaging, Biomarkers and Lifestyle Study of Aging; and Chief Scientific Officer for the Cooperative Research Centre for Mental Health. As a neuroscientist and ageing researcher, Prof Bush has made valuable contributions over the past 25 years to our understanding of the importance of metal biology and oxidative stress in the function and dysfunction of the brain, especially as it is ages and becomes predisposed to degeneration. He has accrued 360+ publications and 26 patents, has presented over 280 invited lectures worldwide (including 24 Plenary), is currently the most highly cited neuroscientist in Australia and is rated in the top 1% of neuroscience researchers worldwide for high impact citations. The steady increase in the proportion of world publications relating to metals in the brain can be largely attributed to the impact of Prof Bush’s work and his pioneering Metals Theory of Age-related Neurodegeneration. Over the course of his career, he has received several awards and honours for his research, most recently the NHMRC Australia Fellowship (2011); Victoria Prize for Science and Innovation (2014); Woodward Medal in Science and Technology (2014); NHMRC Senior Principal Research Fellowship (2016), and citation in The World's Most Influential Scientific Minds (Thomson Reuters, 2014, 2015).

Research Papers

Listed below are Prof Ashley Bush's most recent publications.

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An emergency department intervention and follow-up to reduce suicide risk in the va: Acceptability and effectiveness

Journal

Psychiatric Services

Volume

67

Begin Page

680

Date

1/6/N/A

Author(s)

B Stanley, SR Chaudhury, M Chesin, K Pontoski, AM Bush, KL Knox, GK Brown
Preface

Journal

Not Found

Volume

Not Found

Begin Page

xi

Date

28/4/N/A

Author(s)

AR White, M Aschner, LG Costa, AI Bush
Metals and Alzheimer's Disease: How Far Have We Come in the Clinic?

Journal

Journal Of Alzheimers Disease

Volume

62

Begin Page

1369

Date

1/1/N/A

Author(s)

Paul A Adlard, Ashley I Bush
Alzheimer's Disease: A Journey (f)rom Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies-Gains from AIBL and DIAN Cohort Studies

Journal

Journal Of Alzheimers Disease

Volume

62

Begin Page

965

Date

1/1/N/A

Author(s)

Ralph N Martins, Victor Villemagnen, Hamid R Sohrabi, Pratishtha Chatterjee, Tejal M Shah, Giuseppe Verdile, Paul Fraser, Kevin Taddei, Veer B Gupta, Stephanie R Rainey-Smith, Eugene Hone, Steve Pedrini, Wei Ling Lim, Ian Martins, Shaun Frost, Sunil Gupta, Sid O'Bryant, Alan Rembach, David Ames, Kathryn Ellis, Stephanie J Fuller, Belinda Brown, Samantha L Gardener, Binosha Fernando, Prashant Bharadwaj, Samantha Burnham, Simon M Laws, Anna M Barron, Kathryn Goozee, Eka J Wahjoepramono, Prita R Asih, James D Doecke, Olivier Salvado, Ashley I Bush, Christopher C Rowe, Samuel E Gandy, Colin L Masters
Ionophore and Biometal Modulation of P-glycoprotein Expression and Function in Human Brain Microvascular Endothelial Cells

Journal

Pharmaceutical Research

Volume

35

Begin Page

965

Date

1/4/N/A

Author(s)

MP McInerney, I Volitakis, AI Bush, WA Banks, JL Short, JA Nicolazzo
Copper in brain and neurodegeneration

Journal

Not Found

Volume

Not Found

Begin Page

1

Date

N/A

Author(s)

JR Liddell, AI Bush, AR White
EFFECTS OF DURATION OF ILLNESS ON THERAPEUTIC RESPONSE TO ADJUNCTIVE TREATMENT WITH N-ACETYL CYSTEINE IN SCHIZOPHRENIA

Journal

Schizophrenia Research

Volume

153

Begin Page

S178

Date

1/4/N/A

Author(s)

Marta Rapado-Castro, Michael Berk, Kamalesh Venugopal, Ashley Ian Bush, Seetal Dood, Olivia M Dean
Glutaredoxins employ parallel monothiol-dithiol mechanisms to catalyze thiol-disulfide exchanges with protein disulfides

Journal

Chemical Science

Volume

9

Begin Page

1173

Date

7/2/N/A

Author(s)

Ashwinie A Ukuwela, Ashley I Bush, Anthony G Wedd, Zhiguang Xiao
Novel Defense by Metallothionein Induction Against Cognitive Decline: From Amyloid β1–42-Induced Excess Zn2+to Functional Zn2+Deficiency

Journal

Molecular Neurobiology

Volume

Not Found

Begin Page

1

Date

19/2/N/A

Author(s)

A Takeda, H Tamano, W Hashimoto, S Kobuchi, H Suzuki, T Murakami, M Tempaku, Y Koike, PA Adlard, AI Bush
FERRITIN IN THE CEREBROSPINAL FLUID PREDICTS RATE OF AMYLOID BETA ACCUMULATION IN BIOMARKER-CONFIRMED ALZHEIMER'S DISEASE

Journal

American Journal Of Hematology

Volume

92

Begin Page

E466

Date

1/8/N/A

Author(s)

Scott Ayton, Ibrahima Diouf, Ashley Bush
Iron as a therapeutic target for Parkinson's disease

Journal

Movement Disorders

Volume

33

Begin Page

568

Date

1/4/N/A

Author(s)

Caroline Moreau, James A Duce, Olivier Rascol, Jean-Christophe Devedjian, Daniela Berg, David Dexter, Z Ioav Cabantchik, Ashley I Bush, David Devos
KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE epsilon 4-positive cognitively normal adults with high A beta-amyloid burden

Journal

Scientific Reports

Volume

8

Begin Page

Date

1/2/N/A

Author(s)

Tenielle Porter, Samantha C Burnham, Vincent Dore, Greg Savage, Pierrick Bourgeat, Kimberly Begemann, Lidija Milicic, David Ames, Ashley I Bush, Paul Maruff, Colin L Masters, Christopher C Rowe, Stephanie Rainey-Smith, Ralph N Martins, David Groth, Giuseppe Verdile, Victor L Villemagne, Simon M Laws
Biometals in neurodegenerative diseases: mechanisms and therapeutics

Journal

Not Found

Volume

Not Found

Begin Page

1

Date

28/4/N/A

Author(s)

AR White, M Aschner, LG Costa, AI Bush
What can predict and prevent the long-term use of benzodiazepines?

Journal

Journal Of Psychiatric Research

Volume

97

Begin Page

94

Date

1/2/N/A

Author(s)

Takeo Hata, Tetsufumi Kanazawa, Takeshi Hamada, Masami Nishihara, Ashley Ian Bush, Hiroshi Yoned, Miki Nakajima, Takahiro Katsumata
Concordance Between Cerebrospinal Fluid Biomarkers with Alzheimer's Disease Pathology Between Three Independent Assay Platforms

Journal

Journal Of Alzheimers Disease

Volume

61

Begin Page

169

Date

1/1/N/A

Author(s)

James D Doecke, Alan Rembach, Victor L Villemagne, Shiji Varghese, Stephanie Rainey-Smith, Shannon Sarros, Lisbeth A Evered, Christopher J Fowler, Kelly K Pertile, Rebecca L Rumble, Brett Trounson, Kevin Taddei, Simon M Laws, S Lance Macaulay, Ashley I Bush, Kathryn A Ellis, Ralph Martins, David Ames, Brendan Silbert, Hugo Vanderstichele, Colin L Masters, David G Darby, Qiao-Xin Li, Steven Collins
The Role of Selenium in Neurodegenerative Diseases

Journal

Not Found

Volume

Not Found

Begin Page

35

Date

1/1/N/A

Author(s)

Barbara R Cardoso, Dominic J Hare, Ashley I Bush
Metalloregulation of Protein Clearance: New Therapeutic Avenues for Neurodegenerative Diseases

Journal

Not Found

Volume

Not Found

Begin Page

363

Date

1/1/N/A

Author(s)

Alejandra Ramirez Munoz, Mark A Greenough, Ashley I Bush, Carlos M Opazo
Editorial: The CB2 cannabinoid system: A new strategy in neurodegenerative disorder and neuroinflammation

Journal

Frontiers In Neuroscience

Volume

11

Begin Page

363

Date

6/4/N/A

Author(s)

M Contino, E Capparelli, NA Colabufo, AI Bush
The Aβ peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction

Journal

Biochemistry

Volume

38

Begin Page

363

Date

15/6/N/A

Author(s)

X Huang, CS Atwood, MA Hartshorn, G Multhaup, LE Goldstein, RC Scarpa, MP Cuajungco, DN Gray, J Lim, RD Moir, RE Tanzi, AI Bush
Is ALS caused by an altered oxidative activity of mutant superoxide dismutase?

Journal

Nature Neuroscience

Volume

5

Begin Page

919

Date

N/A

Author(s)

AI BUSH
Alzheimer disease beta-amyloid activity mimics cholesterol oxidase (vol 116, pg 2828, 2006)

Journal

Journal Of Clinical Investigation

Volume

116

Begin Page

2828

Date

1/10/N/A

Author(s)

Luigi Puglielli, Avi L Friedlich, Kenneth DR Setchell, Seiichi Nagano, Carlos Opazo, Robert A Cherny, Kevin J Barnham, John D Wade, Simon Melov, Dora M Kovacs, Ashley I Bush
Metal chaperones: a holistic approach to the treatment of Alzheimer's disease

Journal

Frontiers In Psychiatry

Volume

3

Begin Page

15

Date

N/A

Author(s)

PA Adlard, AI Bush
Physical activity and amyloid-β plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing

Journal

Molecular Psychiatry

Volume

18

Begin Page

875

Date

N/A

Author(s)

BM Brown, JJ Peiffer, K Taddei, JK Lui, SM Laws, VB Gupta, T Taddei, VK Ward, MA Rodrigues, S Burnham, SR Rainey-Smith, VL Villemagne, AI Bush, KA Ellis, CL Masters, DJ Ames, SL Macaulay, C Szoeke, CC Rowe, RN Martins
Erratum: The AIBL Investigators. Increased risk of cognitive impairment in patients with diabetes is associated with metformin (Diabetes Care (2013) 36 (2981-2987))

Journal

Diabetes Care

Volume

36

Begin Page

3850

Date

1/11/N/A

Author(s)

EM Moore, AG Mander, D Ames, MA Kotowicz, RP Carne, H Brodaty, M Woodward, K Boundy, KA Ellis, AI Bush, NG Faux, R Martins, C Szoeke, C Rowe, DA Watters
Erratum: The effect of paraformaldehyde fixation and sucrose cryoprotection on metal concentration in murine neurological tissue (Journal of Analytical Atomic Spectrometry (2013) DOI: 10.1039/C3JA50281C)

Journal

Journal Of Analytical Atomic Spectrometry

Volume

29

Begin Page

1726

Date

1/1/N/A

Author(s)

DJ Hare, JL George, L Bray, I Volitakis, A Vais, TM Ryan, RA Cherny, AI Bush, CL Masters, PA Adlard, PA Doble, DI Finkelstein

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Qualifications

Listed below are Prof Ashley Bush's qualifications.
  • 1982, M.B.,B.S (Medicine), The University of Melbourne
  • 1988, Dipl Psychological Medicine, The University of Melbourne
  • 1989, Fellow, Royal Australian and New Zealand College of Psychiatrists (FRANZCP)
  • 1993, PhD (Pathology), The University of Melbourne

Awards

Listed below are Prof Ashley Bush's awards.
  • NHMRC Senior Principal Research Fellowship (2016)
  • The World's Most Influential Scientific Minds (Thomson Reuters, 2014, 2015)
  • Fellow, Australian Academy of Health and Medical Sciences (2015)
  • Fellow, American Psychiatric Association (2015)
  • The Woodward Medal in Science & Technology, University of Melbourne (2014)
  • Victoria Prize for Science & Innovation (Veski & Victorian Government, 2014)
  • NHMRC Australia Fellowship (2011)
  • The Royal Australian and New Zealand College of Psychiatrists Schering-Plough Senior Research Award (2010)
  • Fellow, The Australian Academy of Technological Sciences and Engineering (2009)
  • Flagship Fellow, CSIRO (2007)
  • Bethlehem Griffiths Research Foundation Award in Neurology (2007)
  • Zenith Fellow, Alzheimer’s Association (2004)
  • Federation Fellow, Australian Research Council (2004)
  • Potamkin Prize, American Academy of Neurology (2003)
  • Alzheimer Association Senator Mark A. Hatfield Award for Clinical Research in Alzheimer's Disease (2000-3)
  • Paul Beeson Physician Faculty Scholar in Aging, American Federation of Aging Research (1995-8)
  • Ellison Scholarship, Massachusetts General Hospital (1994-5)
  • National Down Syndrome Society Scholars Award (1994)
  • Organon Award for Psychiatric Research (1994)
  • Harkness Fellowship, Commonwealth Fund of New York (1992-3)
  • NHMRC Postgraduate Medical Scholarship (1989-92)
  • Victorian Medical Postgraduate Foundation Research Award (1986)