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Staff Directory

Prof Ross Bathgate

Division Head — Neuropeptides

Research Papers

Listed below are Prof Ross Bathgate's most recent publications.

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Challenges in the design of insulin and relaxin/insulin-like peptide mimetics

Journal

Bioorganic And Medicinal Chemistry

Volume

Not Found

Begin Page

Date

1/1/N/A

Author(s)

MA Hossain, RAD Bathgate
Relaxin-3 Inputs Target Hippocampal Interneurons and Deletion of Hilar Relaxin-3 Receptors in "Floxed-RXFP3" Mice Impairs Spatial Memory

Journal

Hippocampus

Volume

27

Begin Page

529

Date

1/5/N/A

Author(s)

M Haidar, G Guevremont, C Zhang, RAD Bathgate, E Timofeeva, CM Smith, AL Gundlach
ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

Journal

Scientific Reports

Volume

7

Begin Page

Date

7/6/N/A

Author(s)

Martina Kocan, Mohsin Sarwar, Sheng Y Ang, Jingbo Xiao, Juan J Marugan, Mohammed A Hossain, Chao Wang, Dana S Hutchinson, Chrishan S Samuel, Alexander I Agoulnik, Ross AD Bathgate, Roger J Summers
Distinct activation modes of the Relaxin Family Peptide Receptor 2 in response to insulin-like peptide 3 and relaxin

Journal

Scientific Reports

Volume

7

Begin Page

Date

12/6/N/A

Author(s)

Shoni Bruell, Ashish Sethi, Nicholas Smith, Daniel J Scott, Mohammed Akhter Hossain, Qing-Ping Wu, Zhan-Yun Guo, Emma J Petrie, Paul R Gooley, Ross AD Bathgate
Characterisation of a cell-free synthesised G-protein coupled receptor

Journal

Scientific Reports

Volume

7

Begin Page

Date

24/4/N/A

Author(s)

Patrick J Shilling, Fabian Bumbak, Daniel J Scott, Ross AD Bathgate, Paul R Gooley
B7-33 replicates the vasoprotective functions of human relaxin-2 (serelaxin)

Journal

European Journal Of Pharmacology

Volume

807

Begin Page

190

Date

15/7/N/A

Author(s)

Sarah A Marshall, Kelly O'Sullivan, Hooi Hooi Ng, Ross AD Bathgate, Laura J Parry, Mohammed Akhter Hossain, Chen Huei Leo
The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4

Journal

Naunyn-schmiedebergs Archives Of Pharmacology

Volume

390

Begin Page

105

Date

1/1/N/A

Author(s)

Sheng Y Ang, Dana S Hutchinson, Bronwyn A Evans, Mohammed A Hossain, Nitin Patil, Ross AD Bathgate, Martina Kocan, Roger J Summers
Promise and Limitations of Relaxin-based Therapies in Chronic Fibrotic Lung Diseases

Journal

American Journal Of Respiratory And Critical Care Medicine

Volume

194

Begin Page

1434

Date

1/12/N/A

Author(s)

Simon G Royce, Ross AD Bathgate, Chrishan S Samuel
Relaxin family peptides: structure-activity relationship studies

Journal

British Journal Of Pharmacology

Volume

174

Begin Page

950

Date

1/5/N/A

Author(s)

Nitin A Patil, K Johan Rosengren, Frances Separovic, John D Wade, Ross AD Bathgate, Mohammed Akhter Hossain
The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1

Journal

Nature Communications

Volume

7

Begin Page

Date

1/4/N/A

Author(s)

Ashish Sethi, Shoni Bruell, Nitin Patil, Mohammed Akhter Hossain, Daniel J Scott, Emma J Petrie, Ross AD Bathgate, Paul R Gooley
A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1

Journal

Chemical Science

Volume

7

Begin Page

3805

Date

1/1/N/A

Author(s)

Mohammed Akhter Hossain, Martina Kocan, Song T Yao, Simon G Royce, Vinojini B Nair, Christopher Siwek, Nitin A Patil, Ian P Harrison, K Johan Rosengren, Stavros Selemidis, Roger J Summers, John D Wade, Ross AD Bathgate, Chrishan S Samuel
Engineering of a Novel Simplified Human Insulin-Like Peptide 5 Agonist

Journal

Journal Of Medicinal Chemistry

Volume

59

Begin Page

2118

Date

10/3/N/A

Author(s)

Nitin A Patil, Richard A Hughes, K Johan Rosengren, Martina Kocan, Sheng Yu Ang, Julien Tailhades, Frances Separovic, Roger J Summers, Johannes Grosse, John D Wade, Ross AD Bathgate, Mohammed Akhter Hossain
Nucleus incertus promotes cortical desynchronization and behavioral arousal

Journal

Brain Structure & Function

Volume

222

Begin Page

515

Date

1/1/N/A

Author(s)

Sherie Ma, Giancarlo Allocca, Emma KE Ong-Palsson, Caitlin E Singleton, David Hawkes, Stuart J McDougall, Spencer J Williams, Ross AD Bathgate, Andrew L Gundlach
Signal transduction pathways activated by insulin-like peptide 5 at the relaxin family peptide RXFP4 receptor

Journal

British Journal Of Pharmacology

Volume

174

Begin Page

1077

Date

1/5/N/A

Author(s)

Sheng Y Ang, Dana S Hutchinson, Nitin Patil, Bronwyn A Evans, Ross AD Bathgate, Michelle L Halls, Mohammed A Hossain, Roger J Summers, Martina Kocan
Knockdown of corticotropin-releasing factor 1 receptors in the ventral tegmental area enhances conditioned fear

Journal

European Neuropsychopharmacology

Volume

26

Begin Page

1533

Date

1/9/N/A

Author(s)

Nicola A Chen, Despina E Ganella, Ross AD Bathgate, Alon Chen, Andrew J Lawrence, Jee Hyun Kim
Development of a Single-Chain Peptide Agonist of the Relaxin-3 Receptor Using Hydrocarbon Stapling

Journal

Journal Of Medicinal Chemistry

Volume

59

Begin Page

7445

Date

25/8/N/A

Author(s)

Keiko Hojo, Mohammed Akhter Hossain, Julien Tailhades, Fazel Shabanpoor, Lilian LL Wong, Emma EK Ong-Palsson, Hanna E Kastman, Sherie Ma, Andrew L Gundlach, K Johan Rosengren, John D Wade, Ross AD Bathgate
In a class of their own-RXFP1 and RXFP2 are unique members of the LGR family

Journal

Frontiers In Endocrinology

Volume

6

Begin Page

Date

7/9/N/A

Author(s)

Emma J Petrie, Samantha Lagaida, Ashish Sethi, Ross AD Bathgate, Paul R Gooley
Enhanced serelaxin signalling in co-cultures of human primary endothelial and smooth muscle cells

Journal

British Journal Of Pharmacology

Volume

173

Begin Page

484

Date

1/2/N/A

Author(s)

M Sarwar, CS Samuel, RA Bathgate, DR Stewart, RJ Summers
Native Chemical Ligation to Minimize Aspartimide Formation during Chemical Synthesis of Small LDLa Protein

Journal

Chemistry-a European Journal

Volume

22

Begin Page

1146

Date

18/1/N/A

Author(s)

Julien Tailhades, Ashish Sethi, Emma J Petrie, Paul R Gooley, Ross A Bathgate, John D Wade, Mohammed A Hossain
The C-terminus of the B-chain of human insulin-like peptide 5 is critical for cognate RXFP4 receptor activity

Journal

Amino Acids

Volume

48

Begin Page

987

Date

1/4/N/A

Author(s)

Nitin A Patil, Ross AD Bathgate, Martina Kocan, Sheng Yu Ang, Julien Tailhades, Frances Separovic, Roger Summers, Johannes Grosse, Richard A Hughes, John D Wade, Mohammed Akhter Hossain
Impeding the adaptive response of prostate cancer to androgen targeted therapies with relaxin receptor antagonist

Journal

Bju International

Volume

116

Begin Page

36

Date

1/8/N/A

Author(s)

Gregor Tevz, Akhter M Hossain, Nathalie Bock, Varinder Jeet, Ross A Bathgate, Elizabeth D Williams, Melanie Lehman, Dietmar W Hutmacher, John D Wade, Colleen C Nelson
Synthetic Covalently Linked Dimeric Form of H2 Relaxin Retains Native RXFP1 Activity and Has Improved In Vitro Serum Stability

Journal

Biomed Research International

Volume

Not Found

Begin Page

Date

1/1/N/A

Author(s)

Vinojini B Nair, Ross AD Bathgate, Frances Separovic, Chrishan S Samuel, Mohammed Akhter Hossain, John D Wade
International Union of Basic and Clinical Pharmacology. XCV. Recent Advances in the Understanding of the Pharmacology and Biological Roles of Relaxin Family Peptide Receptors 1-4, the Receptors for Relaxin Family Peptides

Journal

Pharmacological Reviews

Volume

67

Begin Page

389

Date

1/4/N/A

Author(s)

Michelle L Halls, Ross AD Bathgate, Steve W Sutton, Thomas B Dschietzig, Roger J Summers
Synthesis and pharmacological characterization of a europium-labelled single-chain antagonist for binding studies of the relaxin-3 receptor RXFP3

Journal

Amino Acids

Volume

47

Begin Page

1267

Date

1/6/N/A

Author(s)

Linda M Haugaard-Kedstroem, Lilian LL Wong, Ross AD Bathgate, K Johan Rosengren
Solution Structure, Aggregation Behavior, and Flexibility of Human Relaxin-2

Journal

Acs Chemical Biology

Volume

10

Begin Page

891

Date

1/3/N/A

Author(s)

Linda M Haugaard-Kedstrom, Mohammed Akhter Hossain, Norelle L Daly, Ross AD Bathgate, Ernst Rinderknecht, John D Wade, David J Craik, K Johan Rosengren

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