Quick Project Snapshot

T2 relaxometry

T2 relaxometry is a quantitative MR imaging modality that provides an estimate of the T2 relaxation constant of the imaged tissue. T2 can be altered due to cell damage, with increased T2 relaxation time arising from higher fluid content and potential pathology in the brain in both grey and white matter. Regional T2-relaxometry has been used for many years in the assessment of hippocampal sclerosis at advanced epilepsy imaging centres including here at the Florey. Our team has also developed analysis methods that allow whole-brain T2 maps to be assessed across the entire brain at millimetre spatial resolution.

Selected publications

Abbott DF, Pell GS, Pardoe HR, Jackson GD. Selecting appropriate voxel-based methods for neuroimaging studies. NeuroImage 59(2)885–886 (2012).

Abbott DF, Pell GS, Pardoe H, Jackson GD. Voxel-Based Iterative Sensitivity (VBIS) analysis: methods and a validation of intensity scaling for T2-weighted imaging of hippocampal sclerosis. NeuroImage 44(3):812-819 (2009).

Pell GS, Briellmann RS, Pardoe HR, Abbott DF, and Jackson GD. Composite voxel-based analysis of volume and T2 relaxometry in temporal lobe epilepsy. NeuroImage 39(3): 1151-1161 (2008).

Pell GS, Briellmann RS, Waites AB, Abbott DF, Lewis DP and Jackson GD. Optimized clinical T2 relaxometry with a standard CPMG sequence. J Magn Reson Imaging 23(2):248-52 (2006).

Pell GS, Briellmann RS, Waites AB, Abbott DF, Jackson GD. Voxel-Based Relaxometry: A new approach for analysis of T2 relaxometry changes in epilepsy. NeuroImage 21(2):707-713 (2004).

Profile
HEAD OF LAB
A/Prof David Abbott

Epilepsy Neuroinformatics Laboratory

The Neuroinformatics Laboratory undertakes advanced neuroimaging analysis methods development and applied research to further our understanding of the human brain in health and disease. Whilst the work in the laboratory is relevant to a wide range of brain mapping applications, a particular emphasis of the research is towards methods that can help better understand the causes and consequences of epileptic seizures. This includes implementation, development and application of advanced image analysis procedures for structural and functional magnetic resonance imaging (MRI, fMRI) and electroencephalography (EEG) - including simultaneous EEG & fMRI. These non-invasive imaging modalities together with advanced computational methods are capable of mapping human brain activity at millimetre spatial resolution and millisecond temporal resolution. Our scientists work collaboratively with local and international clinical research teams, sharing analysis methods and data in a multidisciplinary pursuit of discovery.

The Neuroinformatics Laboratory has a range of software publicly available.  Please click below for further information and downloads.

Software Available

 

All Projects by this Lab

Functional neuroimaging analysis to identify brain abnormality in epilepsyArtefact reduction in functional MRIFunctional connectivity and the human brain functional connectomeFunctional MRI Processing PipelinesLaterality of brain functionMorphometryQuantitative voxel-based analysis of qualitative imagesSimultaneous EEG-fMRIT2 relaxometry

Epilepsy

The Florey's Epilepsy division is a world-leading centre for epilepsy research. The division has major groups at both the Florey’s Austin and Parkville campus. The group studies mechanisms that cause epilepsy from the level of cells to the function of the whole brain. We use technologies including advanced MRI and cutting edge cellular physiology techniques to allow us to understand genetic and acquired mechanisms that give rise to epilepsy. Together with our colleagues from The University of Melbourne and across Australia we are working towards finding a cure for epilepsy.

All Labs that operate in this Division

Epilepsy Cognition LaboratoryEpilepsy Neuroinformatics LaboratoryImaging and EpilepsyInnate Phagocytosis LaboratoryIon Channels and Human Diseases LaboratoryNeural Networks LaboratoryNeurophysiology of Excitable Networks LaboratoryPsychology and Experimental NeurophysiologySleep and CognitionTraumatic Brain Injury Laboratory