Sleep and Cognition

Our lab focuses on the role of sleep in memory, affect and neurodegenerative disease. Current work investigates the neurobiology of the neuropeptide orexin on sleep, in particular the influences of orexin receptor antagonists on sleep quality and subsequent performance in tests of memory and emotion in animal models. This work expands into investigations of the role of the orexin system in Alzheimer’s disease and Frontotemporal dementia, and explores the potential of orexin receptor antagonists to modulate disease progression in mouse models of these diseases.


A glimpse at our research

Effect of orexin dual antagonists on emotive memory


The Florey's Epilepsy division is a world-leading centre for epilepsy research. The division has major groups at both the Florey’s Austin and Parkville campus. The group studies mechanisms that cause epilepsy from the level of cells to the function of the whole brain. We use technologies including advanced MRI and cutting edge cellular physiology techniques to allow us to understand genetic and acquired mechanisms that give rise to epilepsy. Together with our colleagues from The University of Melbourne and across Australia we are working towards finding a cure for epilepsy.

All Labs that operate in this Division

Epilepsy Cognition LaboratoryEpilepsy Neuroinformatics LaboratoryImaging and EpilepsyInnate Phagocytosis LaboratoryIon Channels and Human Diseases LaboratoryNeural Networks LaboratoryNeurophysiology of Excitable Networks LaboratoryPsychology and Experimental NeurophysiologySleep and CognitionTraumatic Brain Injury Laboratory