Quick Project Snapshot
We have developed improved methods for acquiring and analysing simultaneously acquired EEG and fMRI and we continue our efforts in this field, particularly targeting the investigation of epilepsy.
Acquisition: Direct detection of artefact in the EEG using carbon-fibre loops
Abbott DF, Masterton RAJ, Archer JS, Fleming SW, Warren AEL, Jackson GD. Constructing carbon fiber motion-detection loops for simultaneous EEG–fMRI. Frontiers in Neurology (Section: Brain Imaging Methods) 5(260)1- 16 (2015) ( doi: 10.3389/fneur.2014.00260 ).
Masterton RAJ, Abbott DF, Fleming SW, Jackson GD. Measurement and reduction of motion and ballistocardiogram artefacts from simultaneous EEG and fMRI recordings. NeuroImage 37(1):202-211 (2007). ( doi: 10.1016/j.neuroimage.2007.02.060 ).
Analysis: Event-related independent component analysis (eICA)
Masterton RAJ, Carney PW, Abbott DF, Jackson GD. Absence epilepsy subnetworks revealed by event-related independent components analysis of functional magnetic resonance imaging. Epilepsia 54(5):801-808 (2013). ( doi:10.1111/epi.12163 ).
Masterton RAJ, Jackson GD, Abbott DF. Mapping brain activity using event-related independent components analysis (eICA): Specific advantages for EEG-fMRI. Neuroimage 70:164-174 (2013) ( doi:10.1016/j.neuroimage.2012.12.025 ).
fMRI response to epileptiform activity
Masterton RAJ, Harvey AS, Archer JS, Lillywhite LM, Abbott DF, Scheffer IE, Jackson GD. Focal epileptiform spikes do not show a canonical BOLD response in patients with benign rolandic epilepsy (BECTS). Neuroimage 51(1):252-60. (2010)
Flanagan D, Abbott DF, Jackson GD. How wrong can we be? The effect of inaccurate mark-up of EEG/fMRI studies in epilepsy. Clinical Neurophysiology 120(9)1637-47 (2009). (Also editorialised on pages 1617–1618).
Federico P, Archer JS, Abbott DF, Jackson GD. Cortical/subcortical BOLD changes associated with epileptic discharges: an EEG-fMRI study at 3T. Neurology 64:1125-1130 (2005) (also editorialised on pp.1108-1110).
Waites AB, Shaw ME, Briellmann RS, Labate A, Abbott DF, Jackson GD. How reliable are fMRI-EEG studies of epilepsy? A nonparametric approach to analysis validation and optimization. Neuroimage 24(1):192-199 (2005).
Federico P, Abbott DF, Briellmann RS, Harvey AS, Jackson GD. Functional MRI of the pre-ictal state. Brain 128(8):1811-1817 (2005).
Archer JS, Abbott DF, Waites AB, Jackson GD. fMRI "deactivation" of the posterior cingulate during generalized spike and wave. Neuroimage 20(4):1915-22 (2003).
Archer JS, Briellmann RS, Syngeniotis A, Abbott DF, Jackson GD. Spike triggered fMRI in reading epilepsy: involvement of left frontal cortex working memory areas. Neurology 60(3):415-421 (2003).
Archer JS, Briellmann RS, Abbott DF, Syngeniotis A, Wellard RM, Jackson GD. Benign Epilepsy with Centro-Temporal Spikes: spike triggered fMRI shows somato-sensory cortex activity. Epilepsia 44(2):200-204 (2003).
Opdam HI, Federico P, Buchanan J, Abbott DF, Fabinyi GCA, Vosmansky M, Bellomo R, Archer JS, Wellard RM, Jackson GD. A sheep model of the study of focal epilepsy using concurrent intracranial EEG and functional MRI. Epilepsia 43(8):779-787 (2002).
Epilepsy Neuroinformatics Laboratory
The Neuroinformatics Laboratory undertakes advanced neuroimaging analysis methods development and applied research to further our understanding of the human brain in health and disease. Whilst the work in the laboratory is relevant to a wide range of brain mapping applications, a particular emphasis of the research is towards methods that can help better understand the causes and consequences of epileptic seizures. This includes implementation, development and application of advanced image analysis procedures for structural and functional magnetic resonance imaging (MRI, fMRI) and electroencephalography (EEG) - including simultaneous EEG & fMRI. These non-invasive imaging modalities together with advanced computational methods are capable of mapping human brain activity at millimetre spatial resolution and millisecond temporal resolution. Our scientists work collaboratively with local and international clinical research teams, sharing analysis methods and data in a multidisciplinary pursuit of discovery.
The Neuroinformatics Laboratory has a range of software publicly available. Please click below for further information and downloads.
All Projects by this LabFunctional neuroimaging analysis to identify brain abnormality in epilepsyArtefact reduction in functional MRIFunctional connectivity and the human brain functional connectomeFunctional MRI Processing PipelinesLaterality of brain functionMorphometryQuantitative voxel-based analysis of qualitative imagesSimultaneous EEG-fMRIT2 relaxometry
The Florey's Epilepsy division is a world-leading centre for epilepsy research. The division has major groups at both the Florey’s Austin and Parkville campus. The group studies mechanisms that cause epilepsy from the level of cells to the function of the whole brain. We use technologies including advanced MRI and cutting edge cellular physiology techniques to allow us to understand genetic and acquired mechanisms that give rise to epilepsy. Together with our colleagues from The University of Melbourne and across Australia we are working towards finding a cure for epilepsy.