Research Papers

• Chronic administration of the methylxanthine propentofylline impairs reinstatement to cocaine by a GLT-1-dependent mechanism
  Neuropsychopharmacology

  • Volume: 39
  • Page(s): 499-506
  • Year: 2014

  Author(s): Reissner, K.J., Brown, R.M., Spencer, S., Tran, P.K., Thomas, C.A., Kalivas, P.W.
  Author(s): Reissner, K.J., Brown, R.M., Spencer, S., Tran, P.K., Thomas, C.A., Kalivas, P.W.
• Glutamatergic mechanisms of comorbidity between acute stress and cocaine self-administration
  Molecular Psychiatry

  • Volume: 21
  • Page(s): 1063-1069
  • Year: 2016

  Author(s): Garcia-Keller, C., Kupchik, Y.M., Gipson, C.D., Brown, R.M., Spencer, S., Bollati, F., Esparza, M.A., Roberts-Wolfe, D.J., Heinsbroek, J.A., Bobadilla, A.-C., Cancela, L.M., Kalivas, P.W.
  Author(s): Garcia-Keller, C., Kupchik, Y.M., Gipson, C.D., Brown, R.M., Spencer, S., Bollati, F., Esparza, M.A., Roberts-Wolfe, D.J., Heinsbroek, J.A., Bobadilla, A.-C., Cancela, L.M., Kalivas, P.W.
• Differences in dietary preferences, personality and mental health in Australian adults with and without food addiction
  Nutrients

  • Volume: 9
  • Year: 2017

  Author(s): Burrows, T., Hides, L., Brown, R., Dayas, C.V., Kay-Lambkin, F.
  Author(s): Burrows, T., Hides, L., Brown, R., Dayas, C.V., Kay-Lambkin, F.
• Extinction of a cocaine-taking context that protects against drug-primed reinstatement is dependent on the metabotropic glutamate 5 receptor
  Addiction Biology

  • Volume: 20
  • Page(s): 482-489
  • Year: 2015

  Author(s): Kim, J.H., Perry, C., Luikinga, S., Zbukvic, I., Brown, R.M., Lawrence, A.J.
  Author(s): Kim, J.H., Perry, C., Luikinga, S., Zbukvic, I., Brown, R.M., Lawrence, A.J.
• Reframing addiction: habit, choice, cues and compulsivity
  Progress in Neuro-Psychopharmacology and Biological Psychiatry

  • Volume: 87
  • Page(s): 1-2
  • Year: 2018

  Author(s): Brown, R.M., Madsen, H.B.
  Author(s): Brown, R.M., Madsen, H.B.
• Addiction-like Synaptic Impairments in Diet-Induced Obesity
  Biological Psychiatry

  • Volume: 81
  • Page(s): 797-806
  • Year: 2017

  Author(s): Brown, R.M., Kupchik, Y.M., Spencer, S., Garcia-Keller, C., Spanswick, D.C., Lawrence, A.J., Simonds, S.E., Schwartz, D.J., Jordan, K.A., Jhou, T.C., Kalivas, P.W.
  Author(s): Brown, R.M., Kupchik, Y.M., Spencer, S., Garcia-Keller, C., Spanswick, D.C., Lawrence, A.J., Simonds, S.E., Schwartz, D.J., Jordan, K.A., Jhou, T.C., Kalivas, P.W.
• Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections
  Nature Neuroscience

  • Volume: 18
  • Page(s): 1230-1232
  • Year: 2015

  Author(s): Kupchik, Y.M., Brown, R.M., Heinsbroek, J.A., Lobo, M.K., Schwartz, D.J., Kalivas, P.W.
  Author(s): Kupchik, Y.M., Brown, R.M., Heinsbroek, J.A., Lobo, M.K., Schwartz, D.J., Kalivas, P.W.
• Adenosine 2A receptors modulate reward behaviours for methamphetamine
  Addiction Biology

  • Volume: 21
  • Page(s): 407-421
  • Year: 2016

  Author(s): Chesworth, R., Brown, R.M., Kim, J.H., Ledent, C., Lawrence, A.J.
  Author(s): Chesworth, R., Brown, R.M., Kim, J.H., Ledent, C., Lawrence, A.J.
• Orexin-1 receptor signalling in the prelimbic cortex and ventral tegmental area regulates cue-induced reinstatement of ethanol-seeking in IP rats
  Addiction Biology

  • Volume: 21
  • Page(s): 603-612
  • Year: 2016

  Author(s): Brown, R.M., Kim, A.K., Khoo, S.Y.-S., Kim, J.H., Jupp, B., Lawrence, A.J.
  Author(s): Brown, R.M., Kim, A.K., Khoo, S.Y.-S., Kim, J.H., Jupp, B., Lawrence, A.J.
• The intersection of stress and reward: BNST modulation of aversive and appetitive states
  Progress in Neuro-Psychopharmacology and Biological Psychiatry

  • Volume: 87
  • Page(s): 108-125
  • Year: 2018

  Author(s): Ch'ng, S., Fu, J., Brown, R.M., McDougall, S.J., Lawrence, A.J.
  Author(s): Ch'ng, S., Fu, J., Brown, R.M., McDougall, S.J., Lawrence, A.J.
• Overview of Animal Models of Drug Addiction: Commonalities to Human Addiction
  Biological Research on Addiction

  • Page(s): 149-157
  • Year: 2013

  Author(s): Overstreet, D.H., Brown, R., Lawrence, A.J., Rezvani, A.H.
  Author(s): Overstreet, D.H., Brown, R., Lawrence, A.J., Rezvani, A.H.
• The story of glutamate in drug addiction and of N-acetylcysteine as a potential pharmacotherapy
  JAMA Psychiatry

  • Volume: 70
  • Page(s): 895-897
  • Year: 2013

  Author(s): Brown, R.M., Kupchik, Y.M., Kalivas, P.W.
  Author(s): Brown, R.M., Kupchik, Y.M., Kalivas, P.W.
• Orexin/hypocretin based pharmacotherapies for the treatment of addiction: DORA or SORA?
  CNS Drugs

  • Volume: 28
  • Page(s): 713-730
  • Year: 2014

  Author(s): Khoo, S.Y.-S., Brown, R.M.
  Author(s): Khoo, S.Y.-S., Brown, R.M.
• Ascending orexinergic pathways and alcohol-seeking
  Current Opinion in Neurobiology

  • Volume: 23
  • Page(s): 467-472
  • Year: 2013

  Author(s): Brown, R.M., Lawrence, A.J.
  Author(s): Brown, R.M., Lawrence, A.J.
• α2δ-1 signaling in nucleus accumbens is necessary for cocaine-induced relapse
  Journal of Neuroscience

  • Volume: 34
  • Page(s): 8605-8611
  • Year: 2014

  Author(s): Spencer, S., Brown, R.M., Quintero, G.C., Kupchik, Y.M., Thomas, C.A., Reissner, K.J., Kalivas, P.W.
  Author(s): Spencer, S., Brown, R.M., Quintero, G.C., Kupchik, Y.M., Thomas, C.A., Reissner, K.J., Kalivas, P.W.
• The Metabotropic Glutamate 5 Receptor Modulates Extinction and Reinstatement of Methamphetamine-Seeking in Mice
  PLoS ONE

  • Volume: 8
  • Year: 2013

  Author(s): Chesworth, R., Brown, R.M., Kim, J.H., Lawrence, A.J.
  Author(s): Chesworth, R., Brown, R.M., Kim, J.H., Lawrence, A.J.
• Knockdown of CRF1 receptors in the ventral tegmental area attenuates cue- and acute food deprivation stress-induced cocaine seeking in mice
  Journal of Neuroscience

  • Volume: 34
  • Page(s): 11560-11570
  • Year: 2014

  Author(s): Chen, N.A., Jupp, B., Sztainberg, Y., Lebow, M., Brown, R.M., Kim, J.H., Chen, A., Lawrence, A.J.
  Author(s): Chen, N.A., Jupp, B., Sztainberg, Y., Lebow, M., Brown, R.M., Kim, J.H., Chen, A., Lawrence, A.J.
• Central orexin (hypocretin) 2 receptor antagonism reduces ethanol self-Administration, but not cue-conditioned ethanol-seeking, in ethanol-preferring rats
  International Journal of Neuropsychopharmacology

  • Volume: 16
  • Page(s): 2067-2079
  • Year: 2013

  Author(s): Brown, R.M., Khoo, S.Y.-S., Lawrence, A.J.
  Author(s): Brown, R.M., Khoo, S.Y.-S., Lawrence, A.J.
• Optogenetic evidence that pallidal projections, not nigral projections, from the nucleus accumbens core are necessary for reinstating cocaine seeking
  Journal of Neuroscience

  • Volume: 33
  • Page(s): 13654-13662
  • Year: 2013

  Author(s): Stefanik, M.T., Kupchik, Y.M., Brown, R.M., Kalivas, P.W.
  Author(s): Stefanik, M.T., Kupchik, Y.M., Brown, R.M., Kalivas, P.W.
• The mGlu5 receptor regulates extinction of cocaine-driven behaviours
  Drug and Alcohol Dependence

  • Volume: 137
  • Page(s): 83-89
  • Year: 2014

  Author(s): Bird, M.K., Lohmann, P., West, B., Brown, R.M., Kirchhoff, J., Raymond, C.R., Lawrence, A.J.
  Author(s): Bird, M.K., Lohmann, P., West, B., Brown, R.M., Kirchhoff, J., Raymond, C.R., Lawrence, A.J.
• Neuroplasticity in addiction: Cellular and transcriptional perspectives

  Frontiers in Molecular Neuroscience

  • Page(s): 1-15
  • Year: 2012

  Author(s): Madsen, H.B., Brown, R.M., Lawrence, A.J.

  Author(s): Madsen, H.B., Brown, R.M., Lawrence, A.J.
• A differential role for the adenosine A2Areceptor in opiate reinforcement vs opiate-seeking behavior
  Neuropsychopharmacology

  • Volume: 34
  • Page(s): 844-856
  • Year: 2009

  Author(s): Brown, R.M., Short, J.L., Cowen, M.S., Ledent, C., Lawrence, A.J.
  Author(s): Brown, R.M., Short, J.L., Cowen, M.S., Ledent, C., Lawrence, A.J.
• MGlu5 and adenosine A 2A receptor interactions regulate the conditioned effects of cocaine
  International Journal of Neuropsychopharmacology

  • Volume: 15
  • Page(s): 995-1001
  • Year: 2012

  Author(s): Brown, R.M., Duncan, J.R., Stagnitti, M.R., Ledent, C., Lawrence, A.J.
  Author(s): Brown, R.M., Duncan, J.R., Stagnitti, M.R., Ledent, C., Lawrence, A.J.
• Compulsive use of dopamine replacement therapy in parkinson's disease: Insights into the neurobiology of addiction
  Addiction

  • Year: 2012

  Author(s): Brown, R.M., Lawrence, A.J.
  Author(s): Brown, R.M., Lawrence, A.J.
• Identification of brain nuclei implicated in cocaine- primed reinstatement of conditioned place preference: A behaviour dissociable from sensitization
  PLoS ONE

  • Volume: 5
  • Year: 2010

  Author(s): Brown, R.M., Short, J.L., Lawrence, A.J.
  Author(s): Brown, R.M., Short, J.L., Lawrence, A.J.
• Investigation of the neuroanatomical substrates of reward seeking following protracted abstinence in mice
  Journal of Physiology

  • Volume: 590
  • Page(s): 2427-2442
  • Year: 2012

  Author(s): Madsen, H.B., Brown, R.M., Short, J.L., Lawrence, A.J.
  Author(s): Madsen, H.B., Brown, R.M., Short, J.L., Lawrence, A.J.
• Neuroplasticity in addiction: Cellular and transcriptional perspectives
  Frontiers in Molecular Neuroscience

  • Year: 2012

  Author(s): Madsen, H.B., Brown, R.M., Lawrence, A.J.
  Author(s): Madsen, H.B., Brown, R.M., Lawrence, A.J.
• The role of orexins/hypocretins in alcohol use and abuse: An appetitive-reward relationship
  Frontiers in Behavioral Neuroscience

  • Year: 2012

  Author(s): Kim, A.K., Brown, R.M., Lawrence, A.J.
  Author(s): Kim, A.K., Brown, R.M., Lawrence, A.J.
• Mglu5 receptor functional interactions and addiction
  Frontiers in Pharmacology

  • Volume: 3 MAY
  • Year: 2012

  Author(s): Brown, R.M., Mustafa, S., Ayoub, M.A., Dodd, P.R., Pfleger, K.D.G., Lawrence, A.J.
  Author(s): Brown, R.M., Mustafa, S., Ayoub, M.A., Dodd, P.R., Pfleger, K.D.G., Lawrence, A.J.
• The mGlu5 receptor antagonist MTEP attenuates opiate self-administration and cue-induced opiate-seeking behaviour in mice
  Drug and Alcohol Dependence

  • Volume: 123
  • Page(s): 264-268
  • Year: 2012

  Author(s): Brown, R.M., Stagnitti, M.R., Duncan, J.R., Lawrence, A.J.
  Author(s): Brown, R.M., Stagnitti, M.R., Duncan, J.R., Lawrence, A.J.
• Mice lacking the α4 nicotinic receptor subunit fail to modulate dopaminergic neuronal arbors and possess impaired dopamine transporter function
  Molecular Pharmacology

  • Volume: 68
  • Page(s): 1376-1386
  • Year: 2005

  Author(s): Parish, C.L., Nunan, J., Finkelstein, D.I., McNamara, F.N., Wong, J.Y., Waddington, J.L., Brown, R.M., Lawrence, A.J., Horne, M.K., Drago, J.
  Author(s): Parish, C.L., Nunan, J., Finkelstein, D.I., McNamara, F.N., Wong, J.Y., Waddington, J.L., Brown, R.M., Lawrence, A.J., Horne, M.K., Drago, J.
• Neurochemistry underlying relapse to opiate seeking behaviour
  Neurochemical Research

  • Volume: 34
  • Page(s): 1876-1887
  • Year: 2009

  Author(s): Brown, R.M., Lawrence, A.J.
  Author(s): Brown, R.M., Lawrence, A.J.
• Adenosine A2A receptors and their role in drug addiction
  Journal of Pharmacy and Pharmacology

  • Volume: 60
  • Page(s): 1409-1430
  • Year: 2008

  Author(s): Brown, R.M., Short, J.L.
  Author(s): Brown, R.M., Short, J.L.