Ms Michele Binder
B.Sc (Hons), M.Sc (Hons)

My research has a particular focus upon a family of receptor tyrosine kinases known as the TAM family - Tyro3, Axl and Mertk- of receptors. This family has been shown to be central to the inhibition of the innate immune response to pathogens and their loss leads to a broad-spectrum autoimmunity in mice.

Work in our laboratory has shown that SNPs within the gene for the Mertk receptor are associated with susceptibility to Multiple Sclerosis. In addition, we have previously shown that the absence of the TAM ligand Gas6 leads to increased oligodendrocyte loss and microglial activation in a toxin-induced model of demyelination, as well as to a delay in remyelination.

My current work is focussed upon elucidating the role of TAM receptor signalling in the control of oligodendrocyte differentiation and myelination, as well as neuroinflammation during demyelination in both animal models and in the human disease.

  • Location

    Florey Institute of Neuroscience and Mental Health
    30 Royal Parade
    Parkville
    3052
    Victoria
    Australia

PROJECTS SUPERVISED

Research Papers

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