Viscerosensory Laboratory

We study the basic neurophysiology underpinning integration of sensory information within the brain

Our focus of study is at the level of the nucleus of the solitary tract (NTS), a region in the brain that first receives signals from visceral organs including those of the cardiovascular, respiratory and gastro intestinal systems. Knowledge about how the brain and internal organs co-ordinate is pertinent to several disease states, autonomic related; hypertension and obesity and mental health; stress and depression.

Sensory signals concerning internal organ function is termed ‘vicserosensory’, blood pressure for example. We study how the neural network within the NTS is organised; how vicserosensory information modifies behaviour (salt appetite) and visceral organ function during disease (hypertension). Equally, how behaviour (stress/depression) and disease (obesity) modify autonomic reflexes to alter visceral organ function.

The primary techniques utilised within the laboratory revolve around in vitro slice electrophysiology. We possess a large skill-set and toolkit to answer a variety of experimental questions including optogentics, chemogenetics, behavioural paradigms (stress), immunohistochemisty, stereotaxic and other recoverable surgeries that frame our synaptic studies within a larger context.

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