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MRI Blood Flow and Brain Connectivity Laboratory

Recent advances in MRI have revolutionised the way we investigate brain structure, brain function, and brain network connectivity.

Our lab's main research interests include the development and application of MRI methods to measure cerebral blood flow (Perfusion MRI), super-resolution MRI methods based on diffusion MRI fibre-tracking (Super-Resolution Track-Weighted Imaging), as well as the role of these methods to study brain structural and functional connectivity.  In particular, we specialise in the development of the two main Perfusion MRI techniques: Dynamic Susceptibility Contrast MRI (DSC-MRI) and Arterial Spin Labelling (ASL). The former is playing a key role in many clinical applications (e.g. stroke, tumours), while the latter provides a powerful quantitative tool to characterise functional connectivity.  

Super-Resolution Track-Weighted Imaging provides a means to exploit the information from whole-brain diffusion MRI fibre-tracking to achieve image resolution not previously possible in the human brain in vivo. This method not only can generate images with exquisite image detail, but also provides a unique framework to combine structural and functional connectivity information, and therefore investigate the structural-function relationships in brain networks. Given that the pathophysiological basis of many brain disorders is related to abnormalities in the structural and/or functional connections, this method is expected to have a major role in clinical neuroscience.

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