Understanding the role of metals in normal and pathological ageing
One of the broad projects within the lab involves understanding how a dyshomeostasis in metal ions (particularly zinc) may precipitate and potentiate neurodegenerative diseases such as Alzheimer's disease and Frontotemporal dementia, as well as other conditions such as normal age-related cognitive decline and the cellular consequences of traumatic brain injury.
We use a variety of techniques, such as in vivo mouse models (animal behavior, surgery, microdialysis, controlled cortical impact TBI model etc), multielectrode arrays (for high throughput electrophysiology), cell culture (primary cultures, cell lines, microfluidic cultures), synaptic RNA profiling using next generation sequencing and other more standard methodologies such as western blot and histological work (stereological analysis using both animal and human tissues) to explore the basic biology and to also address potential therapeutic applications in these conditions. We invite PhD candidates to come and discuss potential projects that interest them in this space.
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