Tyro3 in myelin damage and repair
We have previously established that the loss of Tyro3 results in changes to the ultrastructure of myelin, including a reduction in the thickness of myelin surrounding nerves, as well as changes at the regions known as paranodes, where myelin attaches to the nerves. However, the functional outcomes of these changes remains unclear.
Aim
- Explore the role of Tyro3 during developmental myelination and remyelination following myelin damage, using a mouse strain in which the Tyro3 gene has been deleted.
- Assess the behavioural changes resulting from loss of Tyro3 following myelin damage
- Investigate the role of Tyro3 in myelination, using mice with Tyro3 specifically deleted from neurons or oligodendrocytes
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Figure 1: Tyro3 deficiency is associated with disruptions to paranodal structure.
Research team
Supervisor
Research group
Collaborators
Sarrabeth Stone
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