The TAM family and Multiple Sclerosis
We have identified an important set of three receptors (the TAM family) expressed on both immune cells and oligodendrocytes in the brain which influence the severity of demyelinating disease.
We are currently exploring how these receptors and their ligands limit the extent of demyelination and enhance the capacity for remyelination.
In particular, we are examining whether TAMs exert their beneficial effects by influencing immune cell activation in the periphery or within the central nervous system, and which of the three receptors is predominantly responsible for exerting each of these effects. We are also exploring strategies that involve TAM receptor activation to determine whether this might be a viable strategy to limit disease severity.
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