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The nature of the P2X4 receptor

The P2X4 receptor is a two trans-membrane ion channel activated by ATP. It is highly expressed on monocytic lineage cells (monocytes, macrophages and microglia) and certain neuronal cells and has been shown to play an important role in neuropathic pain.

However, the cellular traffic of this receptor and its co-associated molecules is unclear.  This project will use anti-P2X4 monoclonal antibody to examine the surface and intracellular expression of P2X4 in different cells, and identify the possible membrane complex associated with P2X4. The result could help to better understand this receptor and its role in neuropathic pain.

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