We have developed improved methods for acquiring and analysing simultaneously acquired EEG and fMRI and we continue our efforts in this field, particularly targeting the investigation of epilepsy.
Acquisition: Direct detection of artefact in the EEG using carbon-fibre loops
Abbott DF, Masterton RAJ, Archer JS, Fleming SW, Warren AEL, Jackson GD. Constructing carbon fiber motion-detection loops for simultaneous EEG–fMRI. Frontiers in Neurology (Section: Brain Imaging Methods) 5(260)1- 16 (2015) ( doi: 10.3389/fneur.2014.00260 ).
Masterton RAJ, Abbott DF, Fleming SW, Jackson GD. Measurement and reduction of motion and ballistocardiogram artefacts from simultaneous EEG and fMRI recordings. NeuroImage 37(1):202-211 (2007). ( doi: 10.1016/j.neuroimage.2007.02.060 ).
Analysis: Event-related independent component analysis (eICA)
Masterton RAJ, Carney PW, Abbott DF, Jackson GD. Absence epilepsy subnetworks revealed by event-related independent components analysis of functional magnetic resonance imaging. Epilepsia 54(5):801-808 (2013). ( doi:10.1111/epi.12163 ).
Masterton RAJ, Jackson GD, Abbott DF. Mapping brain activity using event-related independent components analysis (eICA): Specific advantages for EEG-fMRI. Neuroimage 70:164-174 (2013) ( doi:10.1016/j.neuroimage.2012.12.025 ).
fMRI response to epileptiform activity
Masterton RAJ, Harvey AS, Archer JS, Lillywhite LM, Abbott DF, Scheffer IE, Jackson GD. Focal epileptiform spikes do not show a canonical BOLD response in patients with benign rolandic epilepsy (BECTS). Neuroimage 51(1):252-60. (2010)
Flanagan D, Abbott DF, Jackson GD. How wrong can we be? The effect of inaccurate mark-up of EEG/fMRI studies in epilepsy. Clinical Neurophysiology 120(9)1637-47 (2009). (Also editorialised on pages 1617–1618).
Federico P, Archer JS, Abbott DF, Jackson GD. Cortical/subcortical BOLD changes associated with epileptic discharges: an EEG-fMRI study at 3T. Neurology 64:1125-1130 (2005) (also editorialised on pp.1108-1110).
Waites AB, Shaw ME, Briellmann RS, Labate A, Abbott DF, Jackson GD. How reliable are fMRI-EEG studies of epilepsy? A nonparametric approach to analysis validation and optimization. Neuroimage 24(1):192-199 (2005).
Federico P, Abbott DF, Briellmann RS, Harvey AS, Jackson GD. Functional MRI of the pre-ictal state. Brain 128(8):1811-1817 (2005).
Archer JS, Abbott DF, Waites AB, Jackson GD. fMRI "deactivation" of the posterior cingulate during generalized spike and wave. Neuroimage 20(4):1915-22 (2003).
Archer JS, Briellmann RS, Syngeniotis A, Abbott DF, Jackson GD. Spike triggered fMRI in reading epilepsy: involvement of left frontal cortex working memory areas. Neurology 60(3):415-421 (2003).
Archer JS, Briellmann RS, Abbott DF, Syngeniotis A, Wellard RM, Jackson GD. Benign Epilepsy with Centro-Temporal Spikes: spike triggered fMRI shows somato-sensory cortex activity. Epilepsia 44(2):200-204 (2003).
Opdam HI, Federico P, Buchanan J, Abbott DF, Fabinyi GCA, Vosmansky M, Bellomo R, Archer JS, Wellard RM, Jackson GD. A sheep model of the study of focal epilepsy using concurrent intracranial EEG and functional MRI. Epilepsia 43(8):779-787 (2002).
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