Simultaneous EEG-fMRI

We have developed improved methods for acquiring and analysing simultaneously acquired EEG and fMRI and we continue our efforts in this field, particularly targeting the investigation of epilepsy.

Selected publications

Acquisition: Direct detection of artefact in the EEG using carbon-fibre loops

Abbott DF, Masterton RAJ, Archer JS, Fleming SW, Warren AEL, Jackson GD. Constructing carbon fiber motion-detection loops for simultaneous EEG–fMRI. Frontiers in Neurology (Section: Brain Imaging Methods) 5(260)1- 16 (2015) ( doi: 10.3389/fneur.2014.00260 ).

Masterton RAJ, Abbott DF, Fleming SW, Jackson GD. Measurement and reduction of motion and ballistocardiogram artefacts from simultaneous EEG and fMRI recordings. NeuroImage 37(1):202-211 (2007). ( doi: 10.1016/j.neuroimage.2007.02.060 ).

Analysis: Event-related independent component analysis (eICA)

Masterton RAJ, Carney PW, Abbott DF, Jackson GD. Absence epilepsy subnetworks revealed by event-related independent components analysis of functional magnetic resonance imaging. Epilepsia 54(5):801-808 (2013). ( doi:10.1111/epi.12163 ).

Masterton RAJ, Jackson GD, Abbott DF. Mapping brain activity using event-related independent components analysis (eICA): Specific advantages for EEG-fMRI. Neuroimage 70:164-174 (2013) ( doi:10.1016/j.neuroimage.2012.12.025 ).

fMRI response to epileptiform activity

Masterton RAJ, Harvey AS, Archer JS, Lillywhite LM, Abbott DF, Scheffer IE, Jackson GD. Focal epileptiform spikes do not show a canonical BOLD response in patients with benign rolandic epilepsy (BECTS). Neuroimage 51(1):252-60. (2010)

Flanagan D, Abbott DF, Jackson GD. How wrong can we be? The effect of inaccurate mark-up of EEG/fMRI studies in epilepsy. Clinical Neurophysiology 120(9)1637-47 (2009). (Also editorialised on pages 1617–1618).

Federico P, Archer JS, Abbott DF, Jackson GD. Cortical/subcortical BOLD changes associated with epileptic discharges: an EEG-fMRI study at 3T. Neurology 64:1125-1130 (2005) (also editorialised on pp.1108-1110).

Waites AB, Shaw ME, Briellmann RS, Labate A, Abbott DF, Jackson GD. How reliable are fMRI-EEG studies of epilepsy? A nonparametric approach to analysis validation and optimization. Neuroimage 24(1):192-199 (2005).

Federico P, Abbott DF, Briellmann RS, Harvey AS, Jackson GD. Functional MRI of the pre-ictal state. Brain 128(8):1811-1817 (2005).

Archer JS, Abbott DF, Waites AB, Jackson GD. fMRI "deactivation" of the posterior cingulate during generalized spike and wave. Neuroimage 20(4):1915-22 (2003).

Archer JS, Briellmann RS, Syngeniotis A, Abbott DF, Jackson GD.  Spike triggered fMRI in reading epilepsy: involvement of left frontal cortex working memory areas. Neurology 60(3):415-421 (2003).

Archer JS, Briellmann RS, Abbott DF, Syngeniotis A, Wellard RM, Jackson GD. Benign Epilepsy with Centro-Temporal Spikes: spike triggered fMRI shows somato-sensory cortex activity. Epilepsia 44(2):200-204 (2003).

Opdam HI, Federico P, Buchanan J, Abbott DF, Fabinyi GCA, Vosmansky M, Bellomo R, Archer JS, Wellard RM, Jackson GD. A sheep model of the study of focal epilepsy using concurrent intracranial EEG and functional MRI. Epilepsia 43(8):779-787 (2002).

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