Quick Project Snapshot
Nutrition: The control of gut hormone release by nutrients
Gut hormones are essential links in the control of obesity and provide novel opportunities for therapeutic intervention
Program Leaders: Dr Brid Callaghan, Mitchell Ringuet, Linda Fothergill, Billie Hunne, Prof John Furness.
Contact: Dr Callaghan: firstname.lastname@example.org
Control of gut hormone release is important to diabetes, weight control and digestive health. We have made the discovery that hormones that are in the same cells are in separate storage vesicles. Our observation raises the strong possibility that the release of these, and other GI hormones that are colocalised in EEC cells, could be differentially controlled.
In this project you will work with a team to investigate simultaneously the separate subcellular locations and the mobilisation of vesicles that contain 2 or more hormones in mouse enteroendocrine cells. Naturally-occurring and synthetic stimulants of nutrient receptors on enteroendocrine cells will be used to promote vesicle translocation and release.
Immunohistochemistry of EEC
References: Furness, JB, Rivera, LR, Cho, H‐J, Bravo, DM, Callaghan, B: The gut as a sensory organ. Nature Rev. Gastroenterol. Hepatol 10, 729-740 (2013).
Cho H-J, Robinson ES, Rivera LR, McMillan PJ, Testro A, Nikfarjam M, Bravo DM & Furness JB. Glucagon-like peptide 1 and peptide YY are in separate storage organelles in enteroendocrine cells. Cell Tissue Res 357, 63-69 (2014).
Digestive Physiology and Nutrition Laboratory
All Projects by this LabThe taxonomy of enteroendocrine cells and their innervationModulation of intestinal inflammation through nerve stimulationNovel drugs and receptors for targeting neural control of digestive functionThe gastrointestinal complications of Parkinson’s Disease Gut Health: an intersection of food, environment, animal production and global healthNutrition: The control of gut hormone release by nutrients
In Systems Neurophysiology we seek to learn how the nervous system controls various bodily functions and how that control is altered in disease. Our disease focus includes not only neurological disorders such as epilepsy and multiple sclerosis, but also how the nervous system impacts on non-neurological diseases such as heart failure and inflammatory diseases. A clear understanding of basic mechanisms is crucial in developing better therapies and reducing the impacts of illness.