Quick Project Snapshot
Optogenetic modulation of the area tempestas – an epilepsy hot spot
Several lines of study have recently converged to reveal a new target for controlling epileptic seizures. Early work by Piredda and Gale (Nature 1985, 317:623) provided unequivocal evidence that the prepiriform cortex, subsequently coined the “area tempestas”, was a hot spot for initiation and spread of epileptic seizures. Within this region a population of specialised inhibitory neurons called neurogliaform cells (NG) shows a stereotypic pattern of firing that implicates them seizures. In this project the candidate will use in vivo electrophysiological recording and optogenetic stimulation to examine real time modulation of the control of seizures to develop a role for the in vivo function of NG cells and explore their potential utility in seizure suppression.
Ion Channels and Human Diseases Laboratory
Our research focuses on understanding the pathology of ion channel disorders, in particular epilepsy, using in vitro and in vivo models to reveal opportunities for developing novel therapies. We use a multidisciplinary approach spanning ion channel biophysics, mouse transgenesis, genetic analysis, computational modeling and in vitro and in vivo electrophysiology.
All Projects by this Lab“CLARITY” based glass brain imaging in health and diseaseNeuroanatomical determinants of susceptibility in a model of genetic epilepsyMulti-site patch clamp recording of cortical micro networksProjects in network analysis of genetic epilepsyHigh content automated analysis of ion channels in epilepsyHigh density multi-electrode array recording of in vitro networks in epilepsyIn vivo electrophysiological analysis in mouse models of genetic epilepsyMRI tractography in mouse models of genetic epilepsy: Creation of prognostic and diagnostic structural biomarkersOptogenetic modulation of the area tempestas – an epilepsy hot spotTUBEROUS SCLEROSIS AND EPILEPSY: USING RESECTED TISSUE TO UNDERSTAND PATHOGENESIS
The Florey's Epilepsy division is a world-leading centre for epilepsy research. The division has major groups at both the Florey’s Austin and Parkville campus. The group studies mechanisms that cause epilepsy from the level of cells to the function of the whole brain. We use technologies including advanced MRI and cutting edge cellular physiology techniques to allow us to understand genetic and acquired mechanisms that give rise to epilepsy. Together with our colleagues from The University of Melbourne and across Australia we are working towards finding a cure for epilepsy.