Quick Project Snapshot
MRI tractography in mouse models of genetic epilepsy: Creation of prognostic and diagnostic structural biomarkers
Our earlier classical histological analyses have shown that neuronal numbers and positioning are both altered in genetic forms of epilepsy prior to the appearance of overt seizures suggesting that structural changes precede epilepsy. These changes, however, would be below the level of detection of current clinical MRI scanning technology and have led to the potentially erroneous conclusion that idiopathic generalised epilepsy (IGE) is characterised by a complete absence of structural change. By combining recent developments in super resolution MRI (developed by members of the supervisory team) and high field MRI acquisition (16.4T) the candidate will seek to reveal structural changes, or biomarkers, that precede or are a consequence of epilepsy. Because these approaches are directly translatable into the clinic any finding could be rapidly tested in patients. The candidate will develop skills in preparing fixed mouse brains for MRI scanning at 16.4T at the Queensland Brain Institute for analysis using the MRtrix suite of software on a custom workstation to compare brains from control and genetic mouse models.
Richards et al Neuroimage 2014
Ion Channels and Human Diseases Laboratory
Our research focuses on understanding the pathology of ion channel disorders, in particular epilepsy, using in vitro and in vivo models to reveal opportunities for developing novel therapies. We use a multidisciplinary approach spanning ion channel biophysics, mouse transgenesis, genetic analysis, computational modeling and in vitro and in vivo electrophysiology.
All Projects by this Lab“CLARITY” based glass brain imaging in health and diseaseNeuroanatomical determinants of susceptibility in a model of genetic epilepsyMulti-site patch clamp recording of cortical micro networksProjects in network analysis of genetic epilepsyHigh content automated analysis of ion channels in epilepsyHigh density multi-electrode array recording of in vitro networks in epilepsyIn vivo electrophysiological analysis in mouse models of genetic epilepsyMRI tractography in mouse models of genetic epilepsy: Creation of prognostic and diagnostic structural biomarkersOptogenetic modulation of the area tempestas – an epilepsy hot spotTUBEROUS SCLEROSIS AND EPILEPSY: USING RESECTED TISSUE TO UNDERSTAND PATHOGENESIS
The Florey's Epilepsy division is a world-leading centre for epilepsy research. The division has major groups at both the Florey’s Austin and Parkville campus. The group studies mechanisms that cause epilepsy from the level of cells to the function of the whole brain. We use technologies including advanced MRI and cutting edge cellular physiology techniques to allow us to understand genetic and acquired mechanisms that give rise to epilepsy. Together with our colleagues from The University of Melbourne and across Australia we are working towards finding a cure for epilepsy.