Quick Project Snapshot

In vivo electrophysiological analysis in mouse models of genetic epilepsy

In this project the candidate will use multi-site in vivo unit recording in mouse models of genetic epilepsy to investigate network function and dysfunction in freely moving mice.  Using digital high density electrode recording the candidate will implant multiple sites and then record from mice housed in a controlled environment with video monitoring.  One possible addition to these experiments is the incorporation of optogenetic stimulation whilst recording to probe network function in connected networks of behaving mice.  This will provide some of the first views into how real time intervention of networks modulates seizure initiation and termination.

Epilepsy

The Florey's Epilepsy division is a world-leading centre for epilepsy research. The division has major groups at both the Florey’s Austin and Parkville campus. The group studies mechanisms that cause epilepsy from the level of cells to the function of the whole brain. We use technologies including advanced MRI and cutting edge cellular physiology techniques to allow us to understand genetic and acquired mechanisms that give rise to epilepsy. Together with our colleagues from The University of Melbourne and across Australia we are working towards finding a cure for epilepsy.

All Labs that operate in this Division

Epilepsy Cognition LaboratoryEpilepsy Neuroinformatics LaboratoryImaging and EpilepsyInnate Phagocytosis LaboratoryIon Channels and Human Diseases LaboratoryNeural Networks LaboratoryNeurophysiology of Excitable Networks LaboratoryPsychology and Experimental NeurophysiologySleep and CognitionTraumatic Brain Injury Laboratory