Quick Project Snapshot

High density multi-electrode array recording of in vitro networks in epilepsy

In this project the candidate will use high density extracellular multielectrode array recordings to investigate large scale network function. This a level of organization beyond that studied in Project 1 and will reveal fundamental properties of how the hippocampal and thalamocortical networks are altered in genetic models of epilepsy.  The goal of these studies is to not only understand more about the neurobiology of epilepsy but also to create novel disease state models for creating anti-epileptic drugs.  The method will involve cutting fresh brain slices and using 60 site multi-electrode arrays that enable electrical stimulation and recording from all sites simultaneously. Slices will be subject to various stimulation and pharmacological protocols to reveal aspects about excitability, synaptic transmission and plasticity.

Epilepsy

The Florey's Epilepsy division is a world-leading centre for epilepsy research. The division has major groups at both the Florey’s Austin and Parkville campus. The group studies mechanisms that cause epilepsy from the level of cells to the function of the whole brain. We use technologies including advanced MRI and cutting edge cellular physiology techniques to allow us to understand genetic and acquired mechanisms that give rise to epilepsy. Together with our colleagues from The University of Melbourne and across Australia we are working towards finding a cure for epilepsy.

All Labs that operate in this Division

Epilepsy Cognition LaboratoryEpilepsy Neuroinformatics LaboratoryImaging and EpilepsyInnate Phagocytosis LaboratoryIon Channels and Human Diseases LaboratoryNeural Networks LaboratoryNeurophysiology of Excitable Networks LaboratoryPsychology and Experimental NeurophysiologySleep and CognitionTraumatic Brain Injury Laboratory