Quick Project Snapshot

Projects in network analysis of genetic epilepsy

Epilepsy impacts around 3% of the population and in many cases has clear genetic underpinnings.  Our laboratory has created several genetically engineered models of epilepsy that have helped provide the most detailed understanding of how a single gene mutation can lead to behavioural seizures.  Perhaps the largest gap in our understanding lies at the level of the network that bridges cellular and synaptic function with the actual seizure phenotype itself.

Reid et al Brain 2014 Reid et al Neurology 2013 Wimmer et al JCI 2010 Tan et al PNAS 2008

Epilepsy

The Florey's Epilepsy division is a world-leading centre for epilepsy research. The division has major groups at both the Florey’s Austin and Parkville campus. The group studies mechanisms that cause epilepsy from the level of cells to the function of the whole brain. We use technologies including advanced MRI and cutting edge cellular physiology techniques to allow us to understand genetic and acquired mechanisms that give rise to epilepsy. Together with our colleagues from The University of Melbourne and across Australia we are working towards finding a cure for epilepsy.

All Labs that operate in this Division

Epilepsy Cognition LaboratoryEpilepsy Neuroinformatics LaboratoryImaging and EpilepsyInnate Phagocytosis LaboratoryIon Channels and Human Diseases LaboratoryNeural Networks LaboratoryNeurophysiology of Excitable Networks LaboratoryPsychology and Experimental NeurophysiologySleep and CognitionTraumatic Brain Injury Laboratory