Quick Project Snapshot

Multi-site patch clamp recording of cortical micro networks

In this project the candidate will be trained in the use of an emerging method in brain slice electrophysiology that allows for the simultaneous intracellular recording of 4 connected neurons.  Using this recording mode it is possible to examine how neurons function in coupled micro networks in epileptic and normal brains to lead to a deeper understanding of the functional basis of epilepsy.  If the candidate makes sufficient progress and is motivated this project may also expand into network analysis using multiphoton imaging where 50 or more neurons in a living brain can be labelled with a Ca2+ indicator dye and imaged in real time.

Epilepsy

The Florey's Epilepsy division is a world-leading centre for epilepsy research. The division has major groups at both the Florey’s Austin and Parkville campus. The group studies mechanisms that cause epilepsy from the level of cells to the function of the whole brain. We use technologies including advanced MRI and cutting edge cellular physiology techniques to allow us to understand genetic and acquired mechanisms that give rise to epilepsy. Together with our colleagues from The University of Melbourne and across Australia we are working towards finding a cure for epilepsy.

All Labs that operate in this Division

Epilepsy Cognition LaboratoryEpilepsy Neuroinformatics LaboratoryImaging and EpilepsyInnate Phagocytosis LaboratoryIon Channels and Human Diseases LaboratoryNeural Networks LaboratoryNeurophysiology of Excitable Networks LaboratoryPsychology and Experimental NeurophysiologySleep and CognitionTraumatic Brain Injury Laboratory