Quick Project Snapshot
Is neurogenesis in the adult forebrain altered in a mouse model of neurodegeneration?
Using adult born stem cells to replace neurons lost as a consequence of disease has the potential to be of great benefit to sufferers of neurodegenerative disorders. However, despite extensive research efforts that have gone into examining the biology and therapeutic potential of adult stem cells, the precise cues that modulate the birth of neurons in the adult brain remain unknown.
One region of the adult brain known to continuously receive neurons is the olfactory bulb (OB). Adult olfactory precursors divide primarily within the subventricular or subependymal zone (SVZ) of the lateral ventricle, where they differentiate into immature neurons. Neuroblasts then migrate tangentially along the rostral migratory stream(RMS) toward the main OB. When neuroblasts reach the OB, they migrate radially into the granular (GCL) and periglomerular (GL) layers of the OB, where they differentiate into local interneurons.
In an established mouse model of neurodegeneration, the Tau-P301L mouse, this project examines whether changes occur in the:
- rate of stem cell division in the SVZ;
- migration of newly born cells through the RMS; and
- positioning and phenotype of newly born cells in the OB.
Techniques include: immunohistochemistry and stereology.
Respiratory Neurophysiology Laboratory
We study the basic neural mechanisms underlying breathing, how these patterns of nerve activity adjust to accommodate other behaviours such as swallowing, and how they are modified during development and in neurodegenerative disease.
All Projects by this LabCharacterising the degeneration of brainstem neural circuits that control swallowing and breathingIs neurogenesis in the adult forebrain altered in a mouse model of neurodegeneration?
In Systems Neurophysiology we seek to learn how the nervous system controls various bodily functions and how that control is altered in disease. Our disease focus includes not only neurological disorders such as epilepsy and multiple sclerosis, but also how the nervous system impacts on non-neurological diseases such as heart failure and inflammatory diseases. A clear understanding of basic mechanisms is crucial in developing better therapies and reducing the impacts of illness.