Neurochemistry of Metal Ions
Metal ions play vital roles in brain development and function. But they are also toxic and their mishandling in brain cells are associated with multiple neurodegenerative diseases.
My laboratory focuses on the biological inorganic chemistry of metal ions (Cu, Zn, Fe in particular) in neurodegeneration.
We aim for a molecular understanding of the functional roles of these neuro-metals in healthy brain and in disease states.
A glimpse at our researchMolecular mechanism of copper transporting ATPasesBiological inorganic chemistry of copper in the early ubiquitination pathways
Scientists in the Neurodegeneration division interrogate how neurones live, die and can be rescued to improve brain function in degenerative conditions such as Parkinson’s and Motor Neuron Diseases. There is no effective treatment for Motor Neurone Disease and the incidence of Parkinson’s Disease is rising alarmingly in our aging community. Gene abnormalities, energy deprivation, toxic rubbish accumulation and inflammation all contribute to a toxic environment for brain cells. Our teams study these events in animal models and cultured cells, with a view to translating knowledge into new therapies for human patients.