National Dementia Diagnostics Laboratory

NATA/RCPA accreditation number 19256

RCPA NATA Logo

 

Specimen Reception and NDDL over Public Holidays:

The National Dementia Diagnostics Laboratory (NDDL)  is located at the Florey Institute of Neuroscience and Mental Health, in conjunction with the University of Melbourne. The NDDL closes for Victorian and National Public Holidays. Please hold all diagnostic samples at -20oC during affected periods. Contact us for further information about Specimen Reception at the NDDL. 
 

 

Cerebrospinal Fluid Alzheimer Disease Screen

Abeta1-42, Tau, Phospho-Tau

The Cerebrospinal Fluid (CSF) Alzheimer Disease Screen is an ante-mortem diagnostic test that detects alterations in the levels of biomarker proteins, specifically amyloid Abeta42, total-tau and phospho-tau, which are believed to be directly related to the pathophysiology of Alzheimer's disease (AD). Based on international experience, these CSF biomarkers offer approximately 80-90% sensitivity and specificity for clinically overt AD and valuable prognostic information in persons with amnestic mild cognitive impairment (1). The recommendations detailed for CSF handling align with the consensus statement issued by the Alzheimer's Biomarker Standardisation Initiative (2,3).

The sample:

Diagnostic Testing Fees (non-rebatable)

AD screen (three proteins)  $190; any two proteins  $150; any single protein  $100

The test is run fortnightly, except insufficient samples.

 

1. Li et al. Alzheimer disease normative CSF biomarkers validated in PET Aβ characterized subjects from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. J Alzheimer’s Dis. 2015; 48:175–187; Hulstaet et al. Neurology 1999; 52:1555; Hansson et al., Lancet Neurol, 2006;5(3):228-34; Buchhave et al. Arch Gen Psychiatry 2012; 69: 98-106;
2. Vanderstichele et al. Alzheimer's and Dementia 2012; 8:65-73.
3. This laboratory is a member of the Alzheimer's Association QC program.

Contact/Courier details

Email: enquiries-nddl@unimelb.edu.au
Phone: (03) 9035 7243
Facsimile: (03) 9035 8768

Dr Qiao-Xin Li
National Dementia Diagnostics Laboratory
Florey Institute of Neuroscience and Mental Health
Kenneth Myer Building / Melbourne Brain Centre
30 Royal Parade (corner of Genetics Lane)
Enter via Gate 11, rear loading dock
Parkville Victoria 3010

 

14-3-3 CSF Protein Test

The 14-3-3 protein is an ante-mortem, non-specific marker of central nervous system neuronal injury or death. Based on international experience in carefully selected patients, a positive result by Western blotting has approximately 90% sensitivity and specificity for sporadic Creutzfeldt Jakob disease.  False positives are recognized in various disease processes; for example encephalitis, encephalopathies and recent cerebral infarcts.  Unselected sampling is consequently less reliable if the 14-3-3 protein CSF test is used to screen for a possible diagnosis of CJD.  The Australian National Creutzfeldt-Jakob disease Registry (ANCJDR) is the only diagnostic laboratory in Australia that provides 14-3-3 CSF protein testing.

For specific details regarding the specimen requirements and reception, please refer to the main ANCJDR website or contact the ANCJDR main office

Phone: (03) 8344 1949
Fax: (03) 9349 5105
Email:  ancjd-reg@unimelb.edu.au

CO-HEAD OF DIVISION

Professor Philip Beart

Profile
CO-HEAD OF DIVISION

Prof Colin Masters

Profile

Neurodegeneration

Scientists in the Neurodegeneration division interrogate how neurones live, die and can be rescued to improve brain function in degenerative conditions such as Parkinson’s and Motor Neuron Diseases. There is no effective treatment for Motor Neurone Disease and the incidence of Parkinson’s Disease is rising alarmingly in our aging community. Gene abnormalities, energy deprivation, toxic rubbish accumulation and inflammation all contribute to a toxic environment for brain cells. Our teams study these events in animal models and cultured cells, with a view to translating knowledge into new therapies for human patients.



All Labs that operate in this Division

Analytical Neurochemistry Development GroupBiophysics LaboratoryCellular Neurodegeneration LaboratoryCreutzfeldt Jakob Disease Clinical Research GroupMolecular Gerontology LaboratoryMotor Neurone Disease LaboratoryNational Dementia Diagnostics LaboratoryNeurochemistry of Metal IonsNeurogenesis and Neural Transplantation LaboratoryNeuropathology and Neurodegeneration LaboratoryNeuroproteomics and Metalloproteomics LaboratoryNeurotherapeutics LaboratoryOxidation Biology UnitParkinson's Disease LaboratoryPrana LaboratoryPre-clinical Parkinson’s Disease Research LaboratoryPresynaptic Physiology Stem Cells and Neural Development LaboratorySteroid Neurobiology LaboratorySynaptic Neurobiology LaboratoryThe Australian Imaging Biomarker and Lifestyle Study (AIBL)