Quick Project Snapshot
We are investigating changes in the brain associated with different epilepsy phenotypes using various neuroimaging techniques including magnetic resonance imaging (MRI), functional MRI (fMRI), diffusion MRI, Positron Emission Tomography (PET), transcranial magnetic stimulation (TMS) and simultaneous electroencephalography (EEG) + fMRI. We apply our research findings together with current best practice clinical knowledge to improve clinical outcomes for individual patients, in collaboration with the Austin Hospital’s Comprehensive Epilepsy Program (CEP).
Sethi, M., Pedersen, M., Jackson, G.D., 2016. Polymicrogyric Cortex may Predispose to Seizures via Abnormal Network Topology: An fMRI Connectomics Study. Epilepsia 57, e64–e68. doi:10.1111/epi.13304
Newham, B.J.C., Curwood, E.K., Jackson, G.D., Archer, J.S., 2016. Pontine and cerebral atrophy in Lennox–Gastaut syndrome. Epilepsy Research 120, 98–103. doi:10.1016/j.eplepsyres.2015.12.005
Warren, A.E.L., Abbott, D.F., Vaughan, D.N., Jackson, G.D., Archer, J.S., 2016. Abnormal cognitive network interactions in Lennox-Gastaut syndrome: A potential mechanism of epileptic encephalopathy. Epilepsia 57, 812–822. doi:10.1111/epi.13342
Omidvarnia, A., Pedersen, M., Walz, J.M., Vaughan, D.N., Abbott, D.F., Jackson, G.D., 2016. Dynamic regional phase synchrony (DRePS). Hum. Brain Mapp. 37, 1970–1985. doi:10.1002/hbm.23151
Harvey, A.S., Mandelstam, S.A., Maixner, W.J., Leventer, R.J., Semmelroch, M., MacGregor, D., Kalnins, R.M., Perchyonok, Y., Fitt, G.J., Barton, S., Kean, M.J., Fabinyi, G.C.A., Jackson, G.D., 2015. The surgically remediable syndrome of epilepsy associated with bottom-of-sulcus dysplasia. Neurology 84, 2021–2028. doi:10.1212/WNL.0000000000001591
Pedersen, M., Curwood, E.K., Vaughan, D.N., Omidvarnia, A.H., Jackson, G.D., 2015. Abnormal Brain Areas Common to the Focal Epilepsies: Multivariate Pattern Analysis of fMRI. Brain Connectivity 6, 208–215. doi:10.1089/brain.2015.0367
Raffelt, D.A., Smith, R.E., Ridgway, G.R., Tournier, J.-D., Vaughan, D.N., Rose, S., Henderson, R., Connelly, A., 2015. Connectivity-based fixel enhancement: Whole-brain statistical analysis of diffusion MRI measures in the presence of crossing fibres. NeuroImage 117, 40–55. doi:10.1016/j.neuroimage.2015.05.039
Curwood, E.K., Pedersen, M., Carney, P.W., Berg, A.T., Abbott, D.F., Jackson, G.D., 2015. Abnormal cortical thickness connectivity persists in childhood absence epilepsy. Annals of Clinical and Translational Neurology 2, 456–464. doi:10.1002/acn3.178
Vaughan, D.N., Jackson, G.D., 2014. The Piriform Cortex and Human Focal Epilepsy. Frontiers in Neurology 5. doi:10.3389/fneur.2014.00259
Carney, P.W., Jackson, G.D., 2014. Insights into the Mechanisms of Absence Seizure Generation Provided by EEG with Functional MRI. Frontiers in Neurology 5. doi:10.3389/fneur.2014.00162
Carney, P.W., Harvey, A.S., Berkovic, S.F., Jackson, G.D., Scheffer, I.E., 2013. Siblings with refractory occipital epilepsy showing localized network activity on EEG-fMRI. Epilepsia 54, e28–e32. doi:10.1111/epi.12076
Carney, P.W., Masterton, R.A.J., Gill, D., Jackson, G.D., 2013. Nodular heterotopia and absence seizures: fMRI evidence that they may be connected. Epilepsy Research 106, 451–455. doi:10.1016/j.eplepsyres.2013.07.005
Masterton, R.A.J., Carney, P.W., Abbott, D.F., Jackson, G.D., 2013. Absence epilepsy subnetworks revealed by event-related independent components analysis of functional magnetic resonance imaging. Epilepsia 54, 801–808. doi:10.1111/epi.12163
Masterton, R.A., Carney, P.W., Jackson, G.D., 2012. Cortical and thalamic resting-state functional connectivity is altered in childhood absence epilepsy. Epilepsy Research 99, 327–334. doi:10.1016/j.eplepsyres.2011.12.014
Carney, P.W., Masterton, R.A., Flanagan, D., Berkovic, S.F., Jackson, G.D., 2012. The frontal lobe in absence epilepsy: EEG-fMRI findings. Neurology 78, 1157–1165.
Carney, P.W., Masterton, R.A., Harvey, A.S., Scheffer, I.E., Berkovic, S.F., Jackson, G.D., 2010. The core network in absence epilepsy: differences in cortical and thalamic BOLD response. Neurology 75, 904–911.
Imaging and Epilepsy
The Imaging and Epilepsy group is at the forefront of unravelling the structural and functional abnormalities in the human brain that are associated with epilepsy and other neurological disorders. The group includes several collaborating laboratories, each with multidisciplinary teams of scientists, capable of utilising and advancing cutting-edge neuroimaging technology to address key biological questions in health and disease. Major areas of research include the study of brain networks, connectivity, cognition and injury; neuroimaging analysis methods development / neuroinformatics; and clinical translation to improved patient care.
All Projects by this LabEpilepsy Neuroinformatics LaboratoryEpilepsy Cognition LaboratoryPsychology and Experimental NeurophysiologyTraumatic Brain Injury LaboratoryFunctional Connectivity in the BrainClinical Translation
The Florey's Epilepsy division is a world-leading centre for epilepsy research. The division has major groups at both the Florey’s Austin and Parkville campus. The group studies mechanisms that cause epilepsy from the level of cells to the function of the whole brain. We use technologies including advanced MRI and cutting edge cellular physiology techniques to allow us to understand genetic and acquired mechanisms that give rise to epilepsy. Together with our colleagues from The University of Melbourne and across Australia we are working towards finding a cure for epilepsy.