Atomic Pathology Laboratory
Probing the molecular basis of disease requires tools to investigate changes at the atomic level. Chemical reactions dictate how a cell works, and also how things in a cell go wrong. Studying the chemistry that drives disease requires cutting-edge analytical technology. The Analytical Neurochemistry Development Group in the Oxidation Biology Unit is dedicated to applying the latest developments in technology for studying the chemical components of the cell that cause disease.
The group consists of a diverse range of scientists, including group leader Dr Dominic Hare, and analytical chemist with a specific interest in metals and neurodegeneration, Dr Bence Paul, a geochemist specialising in data analysis and mass spectrometry, and Dr Barbara Cardoso, a nutritionist applying these newly developed techniques to studying how the environment around us influences disease processes. Enquiries can be directed to Dominic Hare.
Scientists in the Neurodegeneration division interrogate how neurones live, die and can be rescued to improve brain function in degenerative conditions such as Parkinson’s and Motor Neuron Diseases. There is no effective treatment for Motor Neurone Disease and the incidence of Parkinson’s Disease is rising alarmingly in our aging community. Gene abnormalities, energy deprivation, toxic rubbish accumulation and inflammation all contribute to a toxic environment for brain cells. Our teams study these events in animal models and cultured cells, with a view to translating knowledge into new therapies for human patients.