The CAMARADES collaboration for systematic review and metanalysis of the data supporting the efficacy of candidate therapies for stroke (http://www.camarades.info) has continued to yield important results.
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The EXTEND cinical trial of delayed thrombolytic therapy and biomarker discovery has been funded by CSIRO ($3million) and the first patients recruited. The biomarker component of this large study aims to discover biomarkers able to indicate where an individual is in the temporal evolution of their stroke.
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To be able to study long term plasticity after stroke we have developed animal models of stroke in aged hypertensive and diabetic animals that better reflect to the aging co-morbid human population affected by stroke than the young healthy animals normally used.
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Systematic reviews and meta anlysis has revealed that hypothermia is one of the most potent neuroprotective strategies available. Fully randomised and blinded experiments have been performed to confirm the results of our systematic review and meta-analysis which pointed to hypothermia as one of the most robust neuroprotective strategies.
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We are using systematic review and meta analysis to probe our large database of the published data on the efficacy of more than 1000 drugs to determine which remain good candidates after correcting for experimental bias, lack of statistical power, and examination experimental variables which impinge on measured outcome.
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There is an urgent need to move from treating symptoms of cardiovascular diseases which include stroke, towards treatment of the causes of disease. A prerequisite for this is the identification of the underlying mechanisms of disease.
Learn More“Lulled in the countless chambers of the brain, our thoughts are linked by many a hidden chain; awake but one, and in, what myriads rise!”
