Clare Parish BBiomedSci (Hons) PhD (Monash)
Viertel Senior Medical Research Fellow
Florey Faculty
Our laboratory has a broad research interest relating to repairing the injured brain. There are a number of major research themes running within the laboratory, including: understanding development of dopamine neurons; improving cell-based therapy for Parkinson’s disease; directed differentiation of pluripotent stem cells; molecular mechanisms underlying axonal targeting and synaptogenesis of midbrain dopamine neurons; and exploiting biomaterials to promote neural repair.
Dr. Chris Bye (postdoctoral research associate).
Dr. Chathurini Fernando (research assistant).
Ms. Jessica Kauhausen (postgraduate student).
Ms. Doris Thomas (research assistant)
Ting-Yi Wang (postgraduate student)
Alexandra Rodreiguz (postgraduate student)
Jordan Wright (postgraduate student)
Pluripotent and neural stem cell culture
Quantitative in vitro assays for cell migration and neurite growth
High Performance Liquid Chromatography
Stereotaxic surgery
Neural Transplantation
Disease modeling and behavioural phenotyping in rodents
Immunochemistry
Is situ hybridization histochemistry
NHMRC CDA Fellowship (2010 – 2013)
NHMRC Project grant scheme
Victoria–California Stem Cell Alliance Grant Program, Early Translational Research Grant.
Bethlehem Griffith Research Foundation, Australia, Project grant
National
Dr. Mirella Dottori and Dr. Mark Denham. Centre for Neuroscience, University of Melbourne.
Prof. Martin Pera, University of Melbourne/Florey Neuroscience Institute.
Prof. Colin Pouton and Dr. John Haynes. Monash Institute of Pharmeceutical Sciences, Melbourne.
Assoc Prof. John Forsyth and Dr David Nisbet. Dept Materials Engineering, Monash University.
Prof. Stephen Stacker. Peter MacCallum Cancer Centre,
International
Prof. Ernest Arenas Karolinska Institute, Sweden.
Jan Stenman, Ludwig Institute of Cancer Research, Stockholm, Sweden
B.D. Blakely, C.R. Bye, C.V. Fernando, M.K. Horne, M. Macheda, S.A. Stacker, E. Arenas, C.L. Parish. Wnt5a regulates midbrain dopaminergic axonal morphogenesis PLoS One Mar 31;6(3):e18373 (2011).
M.K. Horne, D.R. Nisbet, J.S. Forsythe, C.L. Parish. Three dimensional nanofibrous scaffolds incorporating immobilized BDNF promote proliferation and differentiation of cortical neural stem cells. Stem Cells & Development. 19(6):843-52, (2010).
C.L. Parish*, E. Lonardo*, S. Ponticelli, D. Marasco, D. Ribeiro, M. Ruvo, S. De Falco, E. Arenas, G. Minchiotti. A synthetic cripto blocking peptide improves embryonic stem cell replacement therapy in Parkinsonian rats. Stem Cells 28(8):1326-37, (2010). IF: 7.7. Citations: 1.
P. Sacchetti, K.M. Sousa, A.C. Hall, I. Liste, K.R. Steffensen, S. Theofilopoulos, C.L. Parish, C. Hazenberg, L. Ährlund Richter, O. Hovatta, J. Gustafsson, and E. Arenas. Liver X Receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells. Cell Stem Cell. 5(4):409-19, (2009).
C.L. Parish, G. Castelo-Branco, N. Rawal, J. Tonnesen, A. Toft Sorensen, C. Salto, M. Kokaia, O. Lindvall and E. Arenas. Wnt5a-treated midbrain neural stem cells improved dopamine cell replacement therapy in Parkinsonian mice. The Journal of Clinical Investigation, 118, 149 (2008).
C.L. Parish, A. Beljajeva, E. Arenas, A. Simon. Neurogenesis and functional recovery in a novel model of Parkinson’s disease. Development, 34(15):2881-7 (2007).
Parish C.L, Arenas E. Stem-cell-based strategies for the treatment of Parkinson's disease.
Neurodegenerative Diseases 4(4):339-47, (2007).
C.L. Parish, S. Parisi, M.G. Persico, E. Arenas and G. Minchiotti. Cripto as a target for improvingembryonic stem cell-based therapy in Parkinson’s disease. Stem Cells. 23(4): 471-476 (2005).
C.L. Parish, J. Drago, D. Stanic, E. Borrelli, D.I. Finkelstein and M.K. Horne. Haloperidol treatment reverses the anatomical and behavioural changes in cocaine dependent mice. Neurobiology of disease, 19: 301-311 (2005).
2C.L. Parish, D.I. Finkelstein, W. Tripanichkul, J. Drago and M.K. Horne. The role of cytokines IL-1, IL-6 and glia in regulating terminal arbour size in mice. The Journal of Neuroscience,22 (18), p 8034-8041. (2002).
C.L. Parish, D.I. Finkelstein, J. Drago, E. Borrelli and M.K. Horne. The role of dopamine receptors in regulating the size of axonal arbors. The Journal of Neuroscience, 21(14), p5147-5157, (2001)
“The human brain now holds the key to our future. We have to recall the image of the planet from outer space: a single entity in which air, water, and continents are interconnected. That is our home.”
