James Wiley
Principal Research Fellow
MD (Syd), FRACP, FRCPA
The Purinergic Signalling laboratory looks at the role of purinergic P2X receptors and their polymorphic variants in various inflammatory and degenerative conditions affecting the brain.
Under certain conditions P2X receptors act like scavenger receptors which quietly remove apoptotic cells while under other conditions these receptors may stimulate neuroinflammation and be associated with disease states. Activation of P2X7 receptors may also lead to oxidative stress and contribute to the extent of damage following brain trauma.
Neurodegeneration; neurotrauma
Flow cytometry; hematology; molecular biology; human genetics
Leukemia Foundation of Australia
Australia and New Zealand Multiple Sclerosis Genetics Consortium
Steven Petrou
“The human brain must continue to frame the problems for the electronic machine to solve.”
