The electrical changes in the brain which give rise to epilepsy remain poorly understood. Using transcranial magnetic stimulation (TMS) we have shown that the increased excitability of the motor cortex occurs in both sides of the brain in generalised epilepsies whereas this hyperexcitability is confined to the side containing the seizure focus in partial epilepsies.
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The brain regulates body temperature, keeping it within a narrow range. The consequences when this fails can be life-threatening: elderly people, whose temperature regulation may be impaired, frequently die of heat stroke during heat waves.
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Heart failure continues to be a major health problem as evidenced by a rise in hospital admissions for heart failure, the number of deaths attributed to heart failure, and the increasing costs associated with care.
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Following an ischaemic event such as a heart attack or stroke, blood flow and thus oxygen transport to the downstream tissue stops and the tissue dies. In tissue around the ischaemic area blood flow and oxygen delivery are reduced, which leads to further cell death and expansion of the damage from the original infarct.
Learn More“The mind loves the unknown, it loves images where meaning is unknown. Since the meaning of the mind itself is unknown.”
