Cell-based repair of the damaged brain remains one of the most highly anticipated applications for stem cells in medical science.
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α-synuclein is a key protein in the pathogenesis of Parkinson’s Disease (PD). It is the predominant protein in Lewy Bodies, which are intraneuronal inclusions found in the substantia nigra in PD.
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MND is characterised by paralysis which begins focally and disseminates, suggesting a spread of degeneration in the nervous system.
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We were one of the first laboratories to demonstrate that endoplasmic reticulum (ER) stress occurs early and is a key point in the pathophysiological cascade that causes MND. Proteins synthesised in the ER are transported to the Golgi apparatus for transport to other parts of the cell.
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Motor neurone disease (MND) is a fatal degenerative condition for which there is no effective remedy. New, successful therapies need to better target pathological processes in MND.
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Glutamate transporters (EAAT1-5) regulate the extracellular concentration of Glu, the major excitatory transmitter of mammalian brain.
Learn More“The mind loves the unknown, it loves images where meaning is unknown. Since the meaning of the mind itself is unknown.”
