Cell-based repair of the damaged brain remains one of the most highly anticipated applications for stem cells in medical science.
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α-synuclein is a key protein in the pathogenesis of Parkinson’s Disease (PD). It is the predominant protein in Lewy Bodies, which are intraneuronal inclusions found in the substantia nigra in PD.
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MND is characterised by paralysis which begins focally and disseminates, suggesting a spread of degeneration in the nervous system.
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We were one of the first laboratories to demonstrate that endoplasmic reticulum (ER) stress occurs early and is a key point in the pathophysiological cascade that causes MND. Proteins synthesised in the ER are transported to the Golgi apparatus for transport to other parts of the cell.
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Motor neurone disease (MND) is a fatal degenerative condition for which there is no effective remedy. New, successful therapies need to better target pathological processes in MND.
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Glutamate transporters (EAAT1-5) regulate the extracellular concentration of Glu, the major excitatory transmitter of mammalian brain.
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