The Brain Protection group is actively engaged in exploiting pre-existing protective mechanisms to prevent neurons from dying after injury. They are interested in identifying drugs that will up-regulate concentrations of NDfip1, a naturally occurring protein that is present in low concentrations in brain cells, but massively increased in surviving neurons after brain injury.
The group has made significant progress in understanding how Ndfip1 improves the survival of brain cells after injury. In animal models, it has demonstrated that Ddfip1 is increased in surviving neurons after experimentally induced stroke.
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