CRF and orexin are neuropeptides implicated in a range of functions including arousal, stress responses and drug-seeking.
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This project has evolved out of ongoing studies that have for some time been examining independently the role of glutamate and adenosine systems in drug-seeking.
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We have studied a group of patients with unilateral carotid arterial disease, and found that extensive remodelling is occurring in a region supplied by the narrowed artery, the motor cortex.
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Alzheimer’s disease is the most common form of dementia. While the causes are not well understood, we know from post-mortem studies that certain proteins (known as plaques and tangles) are found in the brains of patients with AD.
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We have shown that ablation of D1+ cells in the striatum gives rise to Parkinsonian motor symptoms with impairments in gait and balance and abnormal oral functions but no limb dystonia whereas cortical D1+ cell ablation gives rise to limb dystonia without gait or oral function abnormality.
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In this study, we sought to establish a culture aiming to promote the survival and regeneration of adult rat mesencephalon derived dopaminergic neurons.
Learn More“The mind loves the unknown, it loves images where meaning is unknown. Since the meaning of the mind itself is unknown.”
