CRF and orexin are neuropeptides implicated in a range of functions including arousal, stress responses and drug-seeking.
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This project has evolved out of ongoing studies that have for some time been examining independently the role of glutamate and adenosine systems in drug-seeking.
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We have studied a group of patients with unilateral carotid arterial disease, and found that extensive remodelling is occurring in a region supplied by the narrowed artery, the motor cortex.
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Alzheimer’s disease is the most common form of dementia. While the causes are not well understood, we know from post-mortem studies that certain proteins (known as plaques and tangles) are found in the brains of patients with AD.
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We have shown that ablation of D1+ cells in the striatum gives rise to Parkinsonian motor symptoms with impairments in gait and balance and abnormal oral functions but no limb dystonia whereas cortical D1+ cell ablation gives rise to limb dystonia without gait or oral function abnormality.
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In this study, we sought to establish a culture aiming to promote the survival and regeneration of adult rat mesencephalon derived dopaminergic neurons.
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