Tim Aumann
BSc (Hons) PhD (Monash)
Brain Injury and Repair Group
Neurodegeneration Laboratory
Contact Details
Email: | |
Phone: | +61 (0)3 8344 7332 |
Fax: | +61 (0)3 9348 1707 |
Research Interests
Recruitment of new dopamine cells in the Parkinson’s disease brain.
Our laboratory is currently investigating how new dopamine (DA) cells can be made in animal models of Parkinson’s disease (PD). We’ve discovered that changing their excitability can alter the number of DA cells in the part of the brain affected in PD. Importantly, we can completely restore the normal number of DA cells in a mouse PD model by administering a drug that changes cell excitability. We are currently investigating the feasibility of using this drug to treat PD in humans, how this increase in DA cells occurs, and the origins of new DA cells.
Laboratory Techniques
- Electrophysiology (in vivo & in vitro)
- Neurosurgery
- Animal behaviour
- Immunohistochemistry
- Cell culture
- Calcium imaging
Publications and Articles
Aumann, T.D., Rawson, J.A., Finkelstein, D.I. and Horne, M.K. (1994) Projections from the lateral and interposed cerebellar nuclei to the thalamus of the rat: a light and electron microscopic study using single and double anterograde labeling. J. Comp. Neurol. 349:165-181.
Aumann, T.D., Rawson, J.A., Pichitpornchai, C. and Horne, M.K. (1996) Projections from the cerebellar interposed and dorsal column nuclei to the thalamus in the rat: a double anterograde labeling study. J. Comp. Neurol. 368:608-619.
Aumann, T.D. and Horne, M.K. (1996) Ramification and termination of single axons in the cerebello-thalamic pathway of the rat. J. Comp. Neurol. 376:420-430.
Aumann, T.D. and Horne, M.K. (1996) A comparison of the ultrastructure of synapses in the cerebello-rubral and cerebello-thalamic pathways in the rat. Neuroscience Letters 211:175-178.
Churchward, P.R., Butler, E.G., Finkelstein, D.I., Aumann, T.D., Sudbury, A. and Horne, M.K. (1997) A comparison of methods used to detect changes in neuronal discharge patterns. J. Neurosci. Meth. 76:203-210.
Aumann, T.D., Rawson, J.A. and Horne, M.K. (1998) The relationship between monkey dentate cerebellar nucleus activity and kinematic parameters of wrist movement. Exp. Brain Res. 119:179-190.
Aumann, T.D., Ivanusic, J. and Horne, M.K. (1998) Arborization and termination of single motor thalamo-cortical axons in the rat. J. Comp. Neurol. 396:121-130.
Aumann, T.D. and Horne, M.K. (1999) Ultrastructural change at rat cerebello-thalamic synapses associated with volitional motor adaptation. J. Comp. Neurol. 409:71-84.
Aumann, T.D., Redman, S.J. and Horne, M.K. (2000) Long-term potentiation across rat cerebello-thalamic synapses in vitro. Neuroscience Letters 287:151-155.
Aumann, T.D. (2002) Cerebello-thalamic synapses and motor adaptation. The Cerebellum 1:69-77.
Aumann, T.D. and Fetz, E.E. (2004) Oscillatory activity in forelimb muscles of behaving monkeys evoked by microstimulation in the cerebellar nuclei. Neuroscience Letters 361:106-110.
Aumann, T.D., Gantois, I., Egan, K., Vais, A., Tomas, D., Drago, J.D. & Horne, M.K. (2008) SK channel function regulates the dopamine phenotype of neurons in the substantia nigra pars compacta. Exp Neurol (in press).
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