Qian Sang
B Med (China), PhD (Melb)
Senior Research Officer
Neuropeptides Division, Florey Neuroscience Institutes
Neuropeptides Group
Contact Details
E-mail: | |
Phone: | +61 (0)3 8344 0411 |
Fax: | +61 (0)3 9348 1707 |
Research Interests
- Systems neuroscience and molecular/cell biology
- Neural pathways, physiological functions and complex behaviours influenced by relaxin family peptides
- Insulin-like peptide 3/RXFP2 and relaxin/RXFP1 systems in mammalian CNS
Laboratory Techniques
- Cell biology: mammalian tissue culture, including primary cortical cell and embryonic brain slice culture; cellular protein analysis by SDS-PAGE and Western blot
- Molecular biology: extraction, purification and analysis of tissue DNA and RNA; DNA manipulations; gel electrophoresis; PCR and RT-PCR; real-time PCR, in situ hybridization
- Histology: immunohistochemistry, light and electron microscopy; image capture by conventional/confocal microscopy; transmission and scanning electron microscopy; retrograde tracing of neural pathways - Fast Blue and Fluorogold, anterograde and retrograde tracing using DiI in fixed and live tissue
- Physiology: comprehensive analysis of mouse behaviour; EEG recording/telemetry
Selected Publications
1. Sang Q, Wu J, Rao Y, Hsueh YP, Tan S-S. (2002) Slit promotes branching and elongation of neurites of interneurons but not projection neurons from the developing telencephalon. Molecular and Cellular Neuroscience 21:250-65
2. Sang Q, Tan S-S. (2003) Contact-associated neurite outgrowth and branching of immature cortical interneurons. Cerebral Cortex 13:677-83
3. Sang Q, Kim MK, Kumar S, Bye N, Morganti-Kossman MC, Gunnersen J, Fuller S, Hyde L, Beissbarth T, Scott HS, Tan S-S. (2006) Nedd4-WW domain-binding protein 5 (Ndfip1) is associated with neuronal survival after acute cortical brain injury. Journal of Neuroscience 26:7234-44
4. Gundlach AL, Ma S, Sang Q, Shen P-J, Piccenna L, Sedaghat K, Smith CM, Bathgate RAD, Lawrence AJ, Tregear GW, Wade JD, Finkelstein DI, Bonaventure P, Liu C, Lovenberg TW, Sutton SW. (2009) Relaxin family peptides and receptors in mammalian brain – anatomical insights and diverse functional possibilities. Annals of the New York Academy of Sciences 1160: 226-235.
5. Ma S, Sang Q, Lanciego JL, Gundlach AL. (2009) Localization of relaxin-3 in brain of Macaca fascicularis – Identification of a nucleus incertus in primate. Journal of Comparative Neurology (in press).
About
Dementia
More than 162,000 Australians have been diagnosed with dementia, with perhaps as many again in the early stages of dementia.