Associate Professor Anthony Hannan

A/Prof Anthony Hannan
A/Prof Anthony Hannan

BSc (Hons) PhD (Syd)

RD Wright Fellow
Brain Development Group
Laboratory Head, Neural Plasticity Laboratory

Contact Details

Email:

anthony.hannan@florey.edu.au

Phone:

+61 (0)3 8344 7316

Fax:

+61 (0)3 9348 1707

Research Interests and Laboratory Techniques

Additional Information

Publications and Articles

Please see PubMed.

Selected Recent Publications

Research Articles
 
McOmish, C.E., Burrows, E., Howard, M., Scarr, E., Kim, D., Shin, H.-S., Dean, B., van den Buuse, M., Hannan, A.J. (2007) Phospholipase C-β1 knockout mice exhibit endophenotypes modeling schizophrenia which are rescued by environmental enrichment and clozapine administration. Molecular Psychiatry [31 July 2007, Epub ahead of print].

Pang, T.Y.C, Stam, N.C, Nithianantharajah, J., Howard, M.L., Hannan, A.J. (2006) Enhanced physical exercise has differential effects on behavioural and BDNF expression deficits in Huntington’s disease transgenic mice. Neuroscience 141: 569-584.

Grote, H.E., Bull, N.D., Howard, M.L., van Dellen, A., Blakemore, C., Bartlett, P.F. and Hannan, A.J. (2005) Cognitive disorders and neurogenesis deficits in Huntington’s disease mice are rescued by fluoxetine. European Journal of Neuroscience 22: 2081-2088.

Mazarakis, N.K., Cybulska-Klosowicz, A., Grote, H., Pang, T., Van Dellen, A., Kossut, M., Blakemore, C. and Hannan, A.J. (2005) Deficits in experience-dependent cortical plasticity and sensory discrimination learning in presymptomatic Huntington’s disease mice. Journal of Neuroscience 25: 3059-3066.

Spires, T.L., Christoffers, K., Molnar, Z., Kind, P.C., Upton, A.L., Blakemore, C. and Hannan, A.J. (2005) Activity-dependent regulation of synapse and dendritic spine morphology in developing barrel cortex requires phospholipase C-β1 signaling. Cerebral Cortex 15: 385-393.

Spires, T.L., Grote, H.E., Varshney, N.K., Cordery, P.M., van Dellen, A., Ladwiniec, A., Blakemore, C. and Hannan, A.J. (2004a) Environmental enrichment rescues protein deficits in a mouse model of Huntington’s disease, indicating a possible disease mechanism. Journal of Neuroscience 24: 2270-2276.

Spires, T.L., Grote, H.E., Varshney, N.K., Garry, S., Cordery, P.M., van Dellen, A., Blakemore, C. and Hannan, A.J. (2004b) Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6/1 Huntington’s disease transgenic mice. European Journal of Neuroscience 19: 2799-2807.

Hannan, A.J., Blakemore, C., Katsnelson, A., Vitallis, T., Huber, K., Bear, M., Kim, D., Shin, H-S. and Kind, P.C. (2001) PLC-β1, activated via mGluRs, mediates activity-dependent differentiation in the cerebral cortex. Nature Neuroscience 4: 282-288.

Van Dellen, A., Blakemore, C., Deacon, R., York, D. and Hannan, A.J. (2000a) Delaying the onset of Huntington’s in mice. Nature 404: 721-722.

Hannan, A.J., Servotte, S., Katsnelson, A., Sisodiya, S., Blakemore, C., Squier, M. and Molnar, Z. (1999) Characterization of nodular neuronal heterotopia in children. Brain 122: 219-238.

Review Articles

Nithianantharajah, J. and Hannan, A.J. (2007) Dynamic mutations as digital genetic modulators of brain development, function and dysfunction. Bioessays  29: 525-535.

McOmish, C.E. and Hannan, A.J. Enviromimetics: Exploring gene-environment interactions to identify therapeutic targets for brain disorders. Expert Opinion in Therapeutic Targets  11: 899-913.

Spires, T.L. and Hannan, A.J. (2007) Molecular mechanisms mediating pathological plasticity in Huntington’s disease and Alzheimer’s disease. Journal of Neurochemistry 100: 874-882.

Grote, H.E. and Hannan, A.J.  (2007) Regulators of adult neurogenesis in the healthy and diseased brain. Clinical and Experimental Pharmacology and Physiology 34: 533-545.

Nithianantharajah, J. and Hannan, A.J. (2006) Enriched environments, experience-dependent plasticity and disorders of the nervous system. Nature Reviews Neuroscience 7: 697-709.

Spires, T.L. and Hannan, A.J. (2005) Nature, nurture and neurology: Gene-environment interactions in neurodegenerative disease. FEBS Journal 272: 2347-2361.

Van Dellen, A., Grote, H.E. and Hannan, A.J. (2005) Gene-environment interactions, neuronal dysfunction and pathological plasticity in Huntington’s disease. Clinical and Experimental Pharmacology and Physiology 32: 1007-1019.

Hannan, A.J. (2005) Novel therapeutic targets for Huntington’s disease. Expert Opinion on Therapeutic Targets 9: 639-650.

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