A/Prof Andrew Gundlach
BSc (Hons) Dip Ed (Mon) PhD (Melb)
Senior Research Fellow (NHMRC Australia)
Neuropeptides Group
Laboratory Head, Peptide Neurobiology Laboratory
Contact Details
Email: | |
Phone: | +61 (0)3 8344 7324 |
Fax: | +61 (0)3 9348 1707 |
Research Interests
- Investigation of the neural pathways, physiological functions and behaviours influenced by relaxin family peptide-receptor systems
- Investigation of the role of galanin in neural and non-neuronal cells in brain physiology and injury/repair
Current Projects
- Relaxin-3 regulation of septohippocampal theta rhythm and cognition
- Role of relaxin-3 systems in arousal/motivation, stress responses and circadian rhythms
- Behavioural actions of relaxin-3 signalling – insights from a peptide gene knockout mouse
- Relaxin hormone systems in brain – studies in a receptor-gene knockout/reporter mouse
- Insulin-like peptide-3 receptors in corticothalamic-basal ganglia- and limbic-circuits
- Mapping relaxin-family peptide-receptor systems in postmortem human and primate brain
- Role of galanin in demyelinating disease
Laboratory Techniques
- Neuroanatomy – biochemical and functional mapping of circuitry related to peptide pathways and associated behaviours
- Physiology/pharmacology - small animal surgery, whole animal telemetry recordings and behavioural tests after peptide treatment
- Behavioural neuroscience - motor, cognitive and affective test battery studies of gene-deletion mouse strains
- Molecular biology/histochemistry - immunohistochemistry, in situ hybridization and in vitro autoradiography of peptides, receptors and other markers; real time-, RT-PCR peptide/receptor gene analysis
Additional Information
Dr Gundlach has been a NHMRC Research Fellow since 1992 and has been at the Howard Florey Institute since 2000, after heading a laboratory in the Department of Medicine at the Austin & Repatriation Centre from 1989-1999. He undertook postdoctoral training at the Johns Hopkins University and the University of Sydney (1983-1988), and has also been a visiting scientist in Cambridge (1989, 1996) and Paris (2000). He has published over 100 peer-reviewed papers and since 1992 has supervised more than 10 PhD graduates.
Dr Gundlach is currently:
- Associate Professor in the Department of Anatomy and Cell Biology, University of Melbourne
- Deputy-Chair of the HFI Postgraduate Matters Committee
- Member of the IBRO Return Home Programme and Neuroscience Training Programmes Committees
- Handling Editor for Journal of Neurochemistry
Selected Publications
Burazin TCD, Bathgate RAD, Macris M, Layfield S, Gundlach AL, Tregear GW. (2002) Restricted, but abundant, expression of the novel rat gene-3 (R3) relaxin in the dorsal tegmental region of brain. Journal of Neurochemistry 82: 1553-1557.
Shen P-J Larm JA, Gundlach AL. (2003) Expression and plasticity of galanin systems in cortical neurons, oligodendrocyte progenitors and proliferative zones in normal brain and after spreading depression. European Journal of Neuroscience 18: 1362-1376.
Jungnickel SR-F, Gundlach AL. (2005) [125I]-Galanin binding in brain of wildtype, and galanin- and GalR1- knockout mice: Strain and species differences in GalR1 density and distribution. Neuroscience 131: 407-421.
Ma S, Roozendaal B, Burazin TCD, Tregear GW, McGaugh JL, Gundlach AL. (2005) Relaxin in the basolateral amygdala impairs consolidation of fear memory. European Journal of Neuroscience 22: 2117-2122.
Fu P., Shen P-J, Zhao C-X, Scott DJ, Samuel CS, Wade JD, Tregear GW, Bathgate RAD, Gundlach AL. (2006) Leucine rich repeat-containing G-protein-coupled receptor 8 in mature glomeruli of developing and adult rat kidney and inhibition by INSL3 of glomerular cell proliferation. Journal of Endocrinology 189: 397-408.
Ma S, Shen P-J, Burazin TCD, Tregear GW, Gundlach AL. (2006) Comparative localization of LGR7 (RXFP1) mRNA and [33P]-relaxin binding sites in rat brain: Restricted somatic co-expression a clue to relaxin action? Neuroscience 141: 329-344.
Ma S, Bonaventure P, Ferraro T, Shen P-J, Burazin TCD, Bathgate RAD, Liu C, Tregear GW, Sutton SW, Gundlach AL. (2007) Relaxin-3 in GABA projection neurons of nucleus incertus suggests widespread influence on forebrain circuits via G-protein-coupled receptor-135 in the rat. Neuroscience 144: 165-190.
Lang, R, Gundlach, AL, Kofler B (2007) The galanin peptide family: Receptor pharmacology, pleiotropic biological actions, and implications in health and disease. Pharmacology and Therapeutics 115: 177-207.
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